Areas of expertise
Immunology, virology and cancer , Antiviral and antitumor immune responses , Vaccines , Viral oncolysis
- Full Professor
Armand-Frappier Santé Biotechnologie Research Centre
531 des Prairies Blvd.
The main focus of Dr.’s Lamarre laboratory is to understand the mechanisms that permit the establishment of viral persistence both from the host and virus perspectives. We are particularly interested in characterizing the correlates of protection against the hepatitis C virus.
Our research program is divided in three main projects: 1. Characterizing the mechanisms involved in the establishment of viral persistence focusing primarily on the neutralizing antibody response. 2. Developing a novel vaccination platform against chronic viral infections and cancer based on plant virus-like particles.
Dr. Alain Lamarre obtained his B.Sc. from the department of Biological Sciences (1988) at the Université de Montréal and his Ph.D. in Virology and Immunology (1996) from Institut Armand-Frappier. After postdoctoral training in Virology and Immunology at the Institute of Experimental Immunology in Zurich, Switzerland in the laboratory of Profs. Hans Hengartner and Rolf Zinkernagel he joined the INRS-Institut Armand-Frappier in 2002.
He was a CIHR New Investigator Award recipient from 2002 to 2007 and currently holds the Jeanne and J.-Louis Lévesque chair in Immunovirology from the J.-Louis Lévesque Foundation.
The research interests of Dr Lamarre’s laboratory, funded by CIHR and NSERC, are aimed at a better understanding of the mechanisms responsible for viral persistence with the ultimate goal of improving the treatment and prevention of chronic viral infections.
LEBEL, M.-E., CHARTRAND, K., TARRAB, E., SAVARD, P., LECLERC, D. & LAMARRE, A. (2016)
Potentiating Cancer Immunotherapy Using Papaya Mosaic Virus-Derived Nanoparticles,
Nano Letters, 16, 3, 1826-1832.
MURIRA, A., LAPIERRE, P. & LAMARRE, A. (2016)
Evolution of the Humoral Response during HCV Infection: Theories on the Origin of Broadly Neutralizing Antibodies and Implications for Vaccine Design,
Advances in Immunology, 129, 66-107.
MATHIEU, C., BELTRA, J. C., CHARPENTIER, T., BOURBONNAIS, S., SANTO, J. P., LAMARRE, A. & DECALUWE, H. (2015)
IL-2 and IL-15 regulate CD8 memory T-cell differentiation but are dispensable for protective recall responses,
European Journal of Immunology.
LEBEL, M. -E., CHARTRAND, K., LECLERC, D. & LAMARRE, A. (2015)
Plant Viruses as Nanoparticle-Based Vaccines and Adjuvants,
Vaccines (Basel), 3, 3, 620-37.
LAPIERRE, P., JANELLE, V., LANGLOIS, M. P., TARRAB, E., CHARPENTIER, T. & LAMARRE, A. (2015)
Expression of Viral Antigen by the Liver Leads to Chronic Infection Through the Generation of Regulatory T Cells,
CMGH Cellular and Molecular Gastroenterology and Hepatology, 1, 3, 325-341.
LAPIERRE, P. & LAMARRE, A. (2015)
Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis,
J Immunol Res, 2015, 479703.
JANELLE, V. & LAMARRE, A. (2014)
How Informative is the Immune Response Against Surrogate Tumor Antigens to Assess Antitumor Immunity?,
Frontiers in oncology, 4, 135.
JANELLE, V., LANGLOIS, M.-P., TARRAB, E., LAPIERRE, P., POLIQUIN, L. & LAMARRE, A. (2014)
Transient Complement Inhibition Promotes a Tumor-Specific Immune Response through the Implication of Natural Killer Cells,
Cancer Immunol. Res., 2, 3, 200-206.
JANELLE, V., LANGLOIS, M. P., LAPIERRE, P., CHARPENTIER, T., POLIQUIN, L. & LAMARRE, A. (2014)
The Strength of the T Cell Response Against a Surrogate Tumor Antigen Induced by Oncolytic VSV Therapy Does Not Correlate with Tumor Control,
Molecular Therapy, 22, 6, 1198-1210.
JANELLE, V. & LAMARRE, A. (2014)
Role of the complement system in NK cell-mediated antitumor T-cell responses,
OncoImmunology, 3, 1, e27897.
LEBEL, M.-E., DAUDELIN, J.-F., CHARTRAND, K., TARRAB, E., KALINKE, U., SAVARD, P., LABRECQUE, N., LECLERC, D. & LAMARRE, A. (2014)
Nanoparticle Adjuvant Sensing by TLR7 Enhances CD8+ T Cell-Mediated Protection from Listeria Monocytogenes Infection,
Journal of Immunology, 192, 3, 1071-1078.
TERRA, R., WANG, X., HU, Y., CHARPENTIER, T., LAMARRE, A., ZHONG, M., SUN, H., MAO, J., QI, S., LUO, H. & WU, J. (2013)
To Investigate the Necessity of STRA6 Upregulation in T Cells during T Cell Immune Responses,
PLoS ONE, 8, 12, e82808.
WANG, X., HU, Y., CHARPENTIER, T., LAMARRE, A., QI, S., WU, J. & LUO, H. (2013)
TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: Implication of TL1A in humoral immune responses,
Journal of Immunology, 191, 11, 5420-5429.
ZAHN, A., DAUGAN, M., SAFAVI, S., GODIN, D., CHEONG, C., LAMARRE, A. & DI NOIA, J. M. (2013)
Separation of function between isotype switching and affinity maturation in vivo during acute immune responses and circulating autoantibodies in UNG-deficient mice,
Journal of Immunology, 190, 12, 5949-5960.
JANELLE, V., POLIQUIN, L. & LAMARRE, A. (2013)
[Vesicular stomatitis virus in the fight against cancer],
Médecine sciences : M/S, 29, 2, 175-82.
GOULET, M. L., OLAGNIER, D., XU, Z., PAZ, S., BELGNAOUI, S. M., LAFFERTY, E. I., JANELLE, V., ARGUELLO, M., PAQUET, M., GHNEIM, K., RICHARDS, S., SMITH, A., WILKINSON, P., CAMERON, M., KALINKE, U., QURESHI, S., LAMARRE, A., HADDAD, E. K., SEKALY, R. P., PERI, S., BALACHANDRAN, S., LIN, R. & HISCOTT, J. (2013)
Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity,
PLoS Pathogens, 9, 4, e1003298.
CHABOT, S., FAKHFAKH, A., BÉLAND, K., LAMARRE, A., OLDSTONE, M. B. A., ALVAREZ, F. & DJILALI-SAIAH, I. (2013)
Mouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes,
Journal of Autoimmunity, 42, 19-28.
LUO, H., CHARPENTIER, T., WANG, X., QI, S., HAN, B., WU, T., TERRA, R., LAMARRE, A. & WU, J. (2011)
Efnb1 and Efnb2 proteins regulate thymocyte development, peripheral T cell differentiation, and antiviral immune responses and are essential for interleukin-6 (IL-6) signaling
Journal of Biological Chemistry , 286, 48, 41135-41152.
JANELLE, V., BRASSARD, F., LAPIERRE, P., *LAMARRE, A. & *POLIQUIN, L. (2011)
Mutations in the glycoprotein of vesicular stomatitis virus affect cytopathogenicity: potential for oncolytic virotherapy
Journal of Virology , 85, 13, 6513-20
*Contribution égale et auteurs correspondants.
SIDDIQUI, S., TARRAB, E., LAMARRE, A. & BASTA, S. (2010)
Altered immunodominance hierarchies of CD8+ T cells in the spleen after infection at different sites is contingent on high virus inoculum
Microbes and Infection , 12, 4, 324-330.
ORTHWEIN, A., PATENAUDE, A. M., AFFAR, E. B., LAMARRE, A., YOUNG, J. C. & DI NOIA, J. M. (2010)
Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90
Journal of Experimental Medicine , 207, 12, 2751-2765.
ALATERY, A., TARRAB, E., LAMARRE, A. & BASTA, S. (2010)
The outcome of cross-priming during virus infection is not directly linked to the ability of the antigen to be cross-presented
European Journal of Immunology , 40, 8, 2190-2199.
GUEVIN, C., LAMARRE, A. & LABONTE, P. (2009)
Novel HCV replication mouse model using human hepatocellular carcinoma xenografts
Antiviral Research , 84, 1, 14-22.
AXELSSON, F., PERSSON, J., MOREAU, E., CÔTÉ, M. H., LAMARRE, A. & OHLIN, M. (2009)
Novel antibody specificities targeting glycoprotein B of cytomegalovirus identified by molecular library technology
New Biotechnology , 25, 6, 429-436.
LACASSE, P., DENIS, J., LAPOINTE, R., LECLERC, D. & LAMARRE, A. (2008)
Novel plant virus-based vaccine induces protective cytotoxic T-lymphocyte-mediated antiviral immunity through dendritic cell maturation
Journal of Virology , 82, 2, 785-794.
LECLERC, D., BEAUSEIGLE, D., DENIS, J., MORIN, H., PARÃ©, C., LAMARRE, A. & LAPOINTE, R. (2007)
Proteasome-independent major histocompatibility complex class I cross-presentation mediated by papaya mosaic virus-like particles leads to expansion of specific human T cells
Journal of Virology , 81, 3, 1319-1326.
DENIS, J., MAJEAU, N., ACOSTA-RAMIREZ, E., SAVARD, C., BEDARD, M. C., SIMARD, S., LECOURS, K., BOLDUC, M., PARE, C., WILLEMS, B., SHOUKRY, N., TESSIER, P., LACASSE, P., LAMARRE, A., LAPOINTE, R., LOPEZ MACIAS, C. & LECLERC, D. (2007)
Immunogenicity of papaya mosaic virus-like particles fused to a hepatitis C virus epitope: Evidence for the critical function of multimerization
Virology , 363, 1, 59-68.
DEMERS, M., BIRON-PAIN, K., HÉBERT, J., LAMARRE, A., MAGNALDO, T. & ST-PIERRE, Y. (2007)
Galectin-7 in lymphoma: Elevated expression in human lymphoid malignancies and decreased lymphoma dissemination by antisense strategies in experimental model
Cancer Research , 67, 6, 2824-2829.
AXELSSON, F., ADLER, S. P., LAMARRE, A. & OHLIN, M. (2007)
Humoral immunity targeting site I of antigenic domain 2 of glycoprotein B upon immunization with different cytomegalovirus candidate vaccines
Vaccine , 26, 1, 41-46.
HARRIS, N. L., SPOERRI, I., SCHOPFER, J. F., NEMBRINI, C., MERKY, P., MASSACAND, J., URBAN JR, J. F., LAMARRE, A., BURKI, K., ODERMATT, B., ZINKERNAGEL, R. M. & MACPHERSON, A. J. (2006)
Mechanisms of neonatal mucosal antibody protection
Journal of Immunology , 177, 9, 6256-6262.
SENN, B. M., LOPEZ-MACIAS, C., KALINKE, U., LAMARRE, A., ISIBASI, A., ZINKERNAGEL, R. M. & HENGARTNER, H. (2003)
Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections
European Journal of Immunology , 33, 4, 950-61.
MARTINIC, M. M., RÜLICKE, T., ALTHAGE, A., ODERMATT, B., HÖCHLI, M., LAMARRE, A., DUMRESE, T., SPEISER, D. E., KYBURZ, D., HENGARTNER, H. & ZINKERNAGEL, R. M. (2003)
Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC
Proceedings of the National Academy of Sciences of the United States of America , 100, 4, 1861-1866.
MACPHERSON, A. J., LAMARRE, A., HENGARTNER, H. & ZINKERNAGEL, R. M. (2002)
Response to ‘Lack of IgA in Cm-deficient patients’.
Nature Immunol. , 3, 596.
MACPHERSON, A. J. & LAMARRE, A. (2002)
BLySsful interactions between DCs and B cells
Nature Immunology , 3, 9, 798-800.
*ZINKERNAGEL, R. M., *LAMARRE, A., CIUREA, A., HUNZIKER, L., OCHSENBEIN, A. F., MCCOY, K. D., FEHR, T., BACHMANN, M. F., KALINKE, U. & HENGARTNER, H. (2001)
Neutralizing antiviral antibody responses
Advances in Immunology , 79, 1-53.
VOGT, B., ROSCHER, S., ABEL, B., HILDINGER, M., LAMARRE, A., BAUM, C. & VON LAER, D. (2001)
Lack of superinfection interference in retroviral vector producer cells
Human Gene Therapy , 12, 4, 359-65.
MACPHERSON, A. J., LAMARRE, A., MCCOY, K., HARRIMAN, G. R., ODERMATT, B., DOUGAN, G., HENGARTNER, H. & ZINKERNAGEL, R. M. (2001)
IgA production without mu or delta chain expression in developing B cells
Nature Immunology , 2, 7, 625-31.
MACPHERSON, A. J., HUNZIKER, L., MCCOY, K. & LAMARRE, A. (2001)
IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms
Microbes and Infection , 3, 12, 1021-35.
MACPHERSON, A., UHR, T. & LAMARRE, A. (2001)
Immune regulation of the normal intestinal bacterial flora. . In: HART, A. L., STAGG, A. J., GRAFFNER, H., GLISE, H., FALK, P. & KAMM, M. A. (Eds.)
Gut Ecology 39-49.
LOPEZ-MACIAS, C., KALINKE, U., CASCALHO, M., WABL, M., HENGARTNER, H., ZINKERNAGEL, R. M. & LAMARRE, A. (1999)
Secondary rearrangements and hypermutation generate sufficient B cell diversity to mount protective antiviral immunoglobulin responses
Journal of Experimental Medicine , 189, 11, 1791-8.
MCCLINTOCK, K., LAMARRE, A., PARSONS, V., LALIBERTÉ, J. F. & FORTIN, M. G. (1998)
Identification of a 37 kDa plant protein that interacts with the turnip mosaic potyvirus capsid protein using anti-idiotypic-antibodies
Plant Molecular Biology , 37, 2, 197-204.
CHAGNON, F., LAMARRE, A., LACHANCE, C., KRAKOWSKI, M., OWENS, T., LALIBERTÉ, J. F. & TALBOT, P. J. (1998)
Characterization of the expression and immunogenicity of the ns4b protein of human coronavirus 229E
Canadian Journal of Microbiology , 44, 10, 1012-1017.
LAMARRE, A., YU, M. W. N., CHAGNON, F. & TALBOT, P. J. (1997)
A recombinant single chain antibody neutralizes coronavirus infectivity but only slightly delays lethal infection of mice
European Journal of Immunology , 27, 12, 3447-3455.
LAMARRE, A. & TALBOT, P. J. (1997)
Characterization of phage-displayed recombinant anti-idiotypic antibody fragments against coronavirus-neutralizing monoclonal antibodies
Viral Immunology , 10, 4, 175-182.
LAMARRE, A. & TALBOT, P. J. (1995)
Protection from lethal coronavirus infection by immunoglobulin fragments
Journal of Immunology , 154, 8, 3985-3990.
DANIEL, C., LAMARRE, A. & TALBOT, P. J. (1994)
Increased viral titers and enhanced reactivity of antibodies to the spike glycoprotein of murine coronavirus produced by infection at pH 6
Journal of Virological Methods , 50, 1-3, 237-244.
LAMARRE, A., LECOMTE, J. & TALBOT, P. J. (1991)
Antiidiotypic vaccination against murine coronavirus infection
Journal of Immunology , 147, 12, 4256-4262.
LAMARRE, A. & TALBOT, P. J. (1989)
Effect of pH and temperature on the infectivity of human coronavirus 229E
Canadian Journal of Microbiology , 35, 10, 972-974.