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Marie-Claude Sincennes

Areas of expertise

Functional genomics of muscle tissue , Muscle stem cells , Muscular dystrophy , Rhabdomyosarcoma

To come


Armand-Frappier Santé Biotechnologie Research Centre

531, des Prairies Blvd
Laval, Quebec  H7V 1B7


Université du Québec à Chicoutimi

555, boulevard de l’Université
Chicoutimi (Québec) G7H 2B1

See the research centre


Sincennes MC, Brun CE, Lin AYT, Rosembert T, Datzkiw D, Saber J, Ming H, Kawabe Y, Rudnicki MA. Acetylation of PAX7 Controls Muscle Stem Cell Self-renewal and Differentiation Potential in Mice. Nature Communications (2021); 12(1):3253

Addicks GC, Brun CE, Sincennes MC, Stewart AF, Ernst P, Rudnicki MA. MLL1 is Required for Pax7 Expression and Satellite Cell Self-Renewal in Mice. Nature Communications (2019); 10(1):4256

Chang NC, Sincennes MC, Chevalier FP, Brun CE, Lacaria M, Segal s J, Munoz-Canoves P, Ming H, Rudnicki MA. The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment. Cell Stem Cell (2018); 22(5):755-768

Lacour F, Vezin E, Bentzinger CF, Sincennes MC, Giordani L, Ferry A, Mitchell R, Patel K, Rudnicki MA, Chaboissier MC, Chassot AA, Le Grand F. R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways. Cell Rep (2017);18(10):2320-2330

Sincennes MC, Wang YX, Rudnicki MA. Primary Mouse Myoblast Purification using Magnetic Cell Separation. Methods Mol Biol (2017);1556: 41-50

Jahani-Asl A, Yin H, Soleimani VD, Haque T, Luchman HA, Chang NC, Sincennes MC, Puram SV, Scott AM, Lorimer IA, Perkins TJ, Ligon KL, Weiss S, Rudnicki MA, Bonni A. Control of glioblastoma tumorigenesis by feed-forward cytokine signaling. Nat Neurosci. (2016);19(6):798-806

Sincennes MC, Brun CE, Rudnicki MA. Concise Review: Epigenetic regulation of myogenesis in health and disease. Stem Cells Trans Med (2016); 5(3): 282-90

Sincennes MC, Humbert M, Grondin B, Lisi V, Veiga DF, Haman A, Cazaux C, Mashtalir N, Affar el B, Verreault A, Hoang T. The LMO2 oncogene regulates DNA replication in hematopoietic cells. Proc Natl Acad Sci USA (2016); 113(5): 1393-8

Dumont NA, Bentzinger CF, Sincennes MC, Rudnicki MA. Satellite cells and skeletal muscle regeneration. Compr Physiol (2015); 5(3): 1027-59

Lécuyer E, Larivière S, Sincennes MC, Haman A, Lahlil R, Todorova M, Tremblay M, Wilkes BC, Hoang T. Protein stability and transcription factor complex assembly determined by the SCL-LMO2 interaction. J Biol Chem (2007); 282(46): 33649-58