Interested research topics
The main interest of the laboratory lies in understanding how the adaptive immune response is regulated during chronic infections. We are currently focussing on three topics:
1. The development of effector and memory CD8 T-cell responses during chronic infections
We are mainly interested in molecular pathways governing early priming events, induction and maintenance of effector CD8 T-cell responses, and the generation of memory cells.
2. The regulation of CD4 T cell responses during chronic infection
Particular interest is given to immune suppressive pathways operating during chronic infections and aiming at inhibiting CD4 T cell responses.
3. The mechanisms of induction of hypergammaglobulinemia by the protozoan parasite Leishmania donovani
We seek to identify pathways triggered by L. donovani that lead to polyclonal B cell activation and ultimately to hypergammaglobulinemia.
Mai, L.T., Smans, M., Silva-Barrios, S., Fabié, A., and Stäger, S. (2019).
IRF-5 expression in myeloid cells is required for splenomegaly in L. donovani infected mice.
Frontiers in Immunology, 10:3071. doi: 10.3389/fimmu.2019.03071.
Silva-Barrios, S. and Stäger, S. (2019).
Hypergammaglobulinemia sustains the development of regulatory responses during chronic Leishmania donovani infection in mice.
European Journal of Immunology, 49(7): 1082-91.
Fabié, A., Mai, L.T., Dagenais-Lussier, X., Hammami, A., van Grevenymghe, J, and Stäger, S. (2018).
IRF-5 promotes cell death in CD4 T cells during chronic infection.
Cell Reports, 24(5):1163-1175.
Silva-Barrios, S., Charpentier, T., and Stäger, S. (2017).
The deadly dance of B cells with Trypanosomatids.
Trends in Parasitology, 34(2):155-171.
Hammami, A., Abidin, B.M., Charpentier, T., Fabié, A., Duguay, AP, Heinonen K.M., and Stäger, S. (2017).
HIF-1alpha is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis.
PLoS Pathogens, 13(9): e1006616.
Abidin, B.M., Hammami, A., Stäger, S., and Heinonen, K.M. (2017).
Infection-adapted emergency hematopoiesis promotes visceral leishmaniasis.
PLoS Pathogens, 13(8):e1006422.
Silva-Barrios, S. and Stäger, S. (2017).
The role of IFN-I in parasitic infections.
Frontiers in Immunology, pii: S0008-8749(16)30047.
Charpentier, T., Hammami, A., and Stäger, S. (2016).
Hipoxia inducible factor 1 alpha: A critical factor fro the immune response to pathogens and Leishmania.
Cellular Immunology, pii: S0008-8749(16)30047.
Silva-Barrios, S., Smans, M., Duerr C., Qureshi, S.T., Fritz, J.H., Descoteaux, A., and Stäger, S. (2016).
Innate immune B cell activation by Leishmania donovani exacerbates disease and mediates hypergammaglobulinemia.
Cell Reports, 15(11):2427-37.
Hammami, A., Charpentier, T., Smans, M., and Stäger, S. (2015).
IRF-5-mediated inflammation limits CD8 T cell expansion by inducing HIF-1a and impairing dendritic cell functions during Leishmania infection.
PLoS Pathogens, 11(6):e1004938.
Bankoti, R., Gupta, K, Levchenko, A., and Stäger,S. (2012).
Marginal zone B-cells regulate antigen-specific T-cell responses during infection.
Journal of Immunology, 188(8):3961-71.
Paun, A., Joshi, T., Pitha, P.M., and Stäger,S. (2011).
IRF5 deficiency severely impairs the development of T helper 1 responses following Leishmania donovani infection.
PLoS Pathogens, 7 (1): 1001246.
Stäger, S., Joshi, T., and Bankoti, R. (2010).
Immune evasive mechanisms contributing to persistent Leishmania donovani infection.
Immunologic Research, 47 (1): 14.
Ranatunga, D., Hedrich, C.M., Wang, F., McVicar, D.W., Nowak, N., Joshi, T., Fiegenbaum, L., Grant, L.R.,
Stäger,S., and Bream, J.H. (2009). A human IL10 BAC transgene recapitulates myeloid- but not T cell-specific murine IL-10 expression resulting in differential disease outcomes.
Joshi, T., Rodriguez, S., Perovic, V., Cockburn, I., and Stäger,S. (2009).
B7-H1 blockade increases survival of dysfunctional CD8+ T-cells and confers protection against Leishmania donovani infections.