Illustration : Stéphane Lefrançois

Role of two key proteins in the development of neuronal ceroid lipofuscinosis, a genetic neurodegenerative disease

  • Master
  • Doctorate
  • Fall
  • Winter
  • With scholarship

Project description

Mutations in CLN3 and CLN5 proteins result in a neurodegenerative disease in children called Neuronal Ceroid Lipofuscinosis. However, the functions of these proteins is still not well understood, hampering the development of therapeutics for these patients.

We have previously shown that CLN3 and CLN5 control the endosome-to-trans Golgi network sorting of the lysosomal sorting receptors. Our interests are to determine how CLN3/CLN5 regulate other endosomal pathways, and to determine the function of CLN3/CLN5 in other diseases such as Alzheimer’s disease. We use a variety of cell biology and biophysical methods including: fluorescence and confocal microscopy, genome editing using CRISPR/Cas9, induced pluripotent stem cells (iPS cells), image analysis with Single Particle Tracking, and Bioluminescence Resonance Energy Transfer (BRET).


Research area

  • Cell Biology
  • Biophysics


Starting date

Fall 2020 or Winter 2021


Research advisor

Pr. Stéphane Lefrançois


Financial support

Our Research University offers many scholarship programs. Every student-researcher benefits from a grant during their higher education studies. These positions are fully funded by CIHR.


Program

Master’s degree in experimental health sciences or doctorate in biology.


Profile

We are looking for highly motivated individuals with a background in biochemistry, biology or relevant fields.


How to apply

Interested candidates can submit their application to Professor Stéphane Lefrançois by using the online form.

The application must include:

  • cover letter
  • CV
  • copy of most recent university transcripts
Project Stéphane Lefrançois - Role of two key proteins in the development of neuronal ceroid lipofuscinosis, a genetic neurodegenerative disease.

Project title : Role of two key proteins in the development of neuronal ceroid lipofuscinosis, a genetic neurodegenerative disease.

Curriculum vitæ *
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Academic transcript *
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Motivation letter *
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Questions

Stéphane Lefrançois, Ph. D.
stephane.lefrancois@inrs.ca
450 687-5050 # 8860
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