Structural and functional basis of outer-membrane biogenesis

  • Master
  • Doctorate
  • Fall
  • Winter
  • With scholarship

Project description

The laboratory of Prof. Charles Calmettes focuses on the bacterial envelope biogenesis with a particular emphasis on the assembly of outer-membrane proteins in Gram-negative bacteria. The Master or PhD candidate will primarily work on characterizing a trans-envelope protein complex mediating the assembly of specific outer-membrane proteins, some of which contributing to virulence. The research project intends to dissect the molecular mechanism, and explore the substrate specificity of this novel assembly machinery. The candidate will be exposed to complementary methodologies combining biochemistry (protein expression, purification, activity assays), molecular biology (cloning, mutagenesis), proteomics (mass spectrometry), and structural biology (protein crystallography). Ultimately, this project aims at discovering novel anti-infective strategies against bacterial pathogens through the screening and identification of specific inhibitors that prevent virulence factors from bei

Research fields

  • Structural Biology
  • X-ray crystallography
  • Molecular biology
  • Microbiology
  • Mass spectrometry


Research advisor

Charles Calmettes, professor


Starting date

Fall 2020 or Winter 2021


Study program

Master’s degree in applied microbiology (French description) or doctorate in biology (French description)


Financial support

INRS offers many scholarship programs. Every student-researcher benefits from a grant during their higher education studies.


Profile

The candidate should have a bachelor’s degree or a master’s degree (or equivalent for the Ph.D program) depending on the program of interest. Experience in molecular biology (cloning, site-directed mutagenesis), expression/purification of proteins, biochemistry (electrophoresis, enzymology), liposomes, structural biology, and mass spectrometry would be an asset. The candidate must master English (oral and writing)


Location

Armand Frappier Santé Biotechnologie Research Centre
531, boulevard des Prairies
Laval, Québec G3X 1S2
Canada


How to apply

Interested persons can submit their application to Charles Calmettes in a single PDF file by using the online form. The application must include:

  • Motivation letter (maximum 1 page) describing their research interests
  • Complete CV
  • The name of three contact information for further reference.
Project Charles Calmettes - Structural and functional basis of outer-membrane biogenesis

Project title : Structural and functional basis of outer-membrane biogenesis

Curriculum vitæ *
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Academic transcript *
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Motivation letter *
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Questions

Charles Calmettes
Email: charles.calmettes@iaf.inrs.ca
Phone: 450-687-5010 extension 8885