The essential oils (EOs) and their chemical constituents are known to be active against a wide range of viruses like herpes simplex virus type 1 (HSV 1) (Astani et al., 2010). The active compounds in essential oils are normally terpenes, especially monoterpenes and phenolic compounds that are the volatiles part in essential oils. Some reports on natural extracts and essential oils have demonstrated antiviral activity against coronaviruses to some extent in both emulsion phase and vapor phase (Mani et al., 2020). Since the new strain of coronavirus causing covid-19 is not fully understood, it is not yet possible to find which EOs could offer the best level of protection. However, it is plausible to assume that some of the EOs and related terpenes are likely to offer a measurable level of defense in the same way that they do with other known viruses such as HSV 1. We have demonstrated in several studies that EOs in vapor or in solution can inhibit bacteria and fungus, and even some viruses such as norovirus (Gobeil et al., 2020).
The main objectives of the current project are : (1) To evaluate the minimum inhibitory concentrations (MIC) and fractional inhibitory concentrations (checkerboard method) of EOs (FIC calculation: evaluation of the synergy between EOs) under emulsion form against a mouse hepatitis virus (MHV) : a surrogate of level 2 coronavirus (Covid-19) using broth microdilution and checkerboard method; (2) To evaluate the MIC and FIC of EOs in vapor form against MHV using a new broth volatilization checkerboard method; (3) To develop an EOs formulation that could be applied under solution or vapor form on MHV. The results of the study will allow the development anti Covid-19 formulations under the form of emulsion or for vapor application for diverse applications such as working on food surface or even for air decontamination.
Fall 2020 or Winter 2021
Review of applications begins immediately and will continue until the position is filled. The postdoc is expected to start as soon as possible.
This project supported by NSERC for one year in the context of Covid-19. The postdoc fellow will receive about 50 000 $ / year.
The candidate will have a PhD in virology and experience in human cell culture in order to produce virus particles. Independence, motivation, good communication skills and a willingness to work as part of a team are required. The candidate will have the opportunity and be supported into developing new projects.
Armand-Frappier Santé Biotechnologie Research Centre
531, boulevard des Prairies
Laval, Québec G7V 1B7
How to apply
Interested candidates can submit their application in a single PDF to Monique Lacroix by using the online form. The application must include:
- one-page summary of thei research interests
- a complete curriculum vitae
- the name of contact information for three references.