1.0INRShttps://inrs.ca/en/inrsadminhttps://inrs.ca/en/author/inrsadmin/rich600338<blockquote class="wp-embedded-content" data-secret="z3rrGeJAht"><a href="https://inrs.ca/en/research/professors/maritza-jaramillo/">Maritza Jaramillo</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://inrs.ca/en/research/professors/maritza-jaramillo/embed/#?secret=z3rrGeJAht" width="600" height="338" title="“Maritza Jaramillo” — INRS" data-secret="z3rrGeJAht" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script type="text/javascript"> /* <![CDATA[ */ /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); /* ]]> */ </script> https://inrs.ca/wp-content/uploads/Maritza-Jaramillo-0045_JLecompte_H_72DPI_Profil-scaled.jpg25601707 Biography Dr. Maritza Jaramillo received her undergraduate degree in Biology from Universidad Nacional de Colombia (Bogotá, Colombia). Subsequently, she completed her MSc and PhD in Microbiology and Immunology at Université Laval (Quebec, QC, Canada) under the supervision of Dr. Martin Olivier. During his graduate studies, Dr. Jaramillo worked on the transcriptional regulation of pro-inflammatory molecules induced during protozoan parasitic infections. Subsequently, she began her postdoctoral research in Dr. Nahum Sonenberg's laboratory at McGill University (Montreal, QC, Canada), where she worked on translational control of infectious diseases. In May 2012 Dr. Jaramillo joined the Faculty of INRS - Centre Armand-Frappier Santé Biotechnologie (CAFSB)  as an Assistant Professor to investigate the mechanisms and the functional consequences of dysregulated mRNA metabolism during toxoplasmosis. In May 2018 Dr. Jaramillo was granted tenure and was promoted to the rank of Associate Professor.  Research Interests Congenital toxoplasmosis is an infectious disease caused by Toxoplasma gondii (T. gondii), an obligate intracellular parasite commonly transmitted to humans by ingestion of contaminated raw meat, water, or soil. During pregnancy, T. gondii infection can lead to miscarriage, premature births, or serious birth defects (e.g. blindness, hydrocephalus, and mental retardation). It is estimated that ~30-40% of the world population is seropositive and that >90% of women in childbearing age are at risk of contractingthe parasite. Unfortunately, efficient and safe vaccines are lacking and available treatments often display teratogenic side effects. Hence, it has become critical to understand the molecular mechanisms underlying the interactions between T. gondii and the infected patient, particularly at the mother/fetus interface. In light of this problem, Dr. Jaramillo’s group investigates how dysregulation of host mRNA turnover and protein synthesis during T. gondii infection contributes to disrupt normal functions of placental cell populations including resident macrophages and trophoblasts, which are essential for embryo implantation and fetal development. Her studies also rely on the use of clinical samples from infected pregnant women and the ex vivo model of placental explants obtained from healthy donors. These valuable resources help validate data obtained in vitro and assess the implications of such findings in a clinical setting. Dr. Jaramillo’s long-term goal is to advance our understanding of the biological underpinnings implicated during congenital toxoplasmosis and to devise ways to thwart T. gondii replication and transmission. Ultimately, she wishes to provide insight into the pathogenesis of clinically relevant infectious organisms and to pave the way to safer therapies to prevent illnesses and promote healthy pregnancies.  Research Funding Currently, Dr. Jaramillo's research program is funded by a CIHR Project Grant (OCT/2019 - SEP/2024) and an NSERC Discovery Grant (APR/2019 - MAR/2024).  Selected Publications Hoang HD1, Graber TE1, Jia JJ, Vaidya N, Gilchrist V, Li W, Gkogkas CG, Jaramillo M, Jafarnejad SM, Alain, T. 2019. Induction of an alternative 5’ leader enhances translation of Inpp5e and resistance to oncolytic virus infection. 1Equal contribution. Cell Reports 29:4010-4023 doi.org/10.1016/j.celrep.2019.11.072 William M1, Leroux LP1, Chaparro V, Graber TE, Alain T, Jaramillo M. 2019. Translational repression of Ccl5 and Cxcl10 by 4E-BP1 and 4E-BP2 restrains the ability of mouse macrophages to induce migration of activated T cells. 1Equal contribution. European Journal of Immunology. DOI 10.1002/eji.201847857 Chaparro V, Leroux LP, Zimmermann A, Jardim A, Johnston B, Descoteaux A, Jaramillo M. 2019. Leishmania donovani lipophosphoglycan increases macrophage-dependent chemotaxis of CXCR6-expressing cells via CXCL16 induction. Infection and Immunity 87:e00064-19. DOI 10.1128/IAI.00064-19 Atayde V, da Silva Lira Filho A, Chaparro V,  Zimmermann A, Jaramillo M, Olivier M. 2019. Leishmania RNA Virus 1 exploits the Leishmania exosomal pathway for successful propagation and infection. Nature Microbiology DOI: 10.1038/s41564-018-0352-y Leroux LP, Lorent J1, Graber TE1, Chaparro V, Masvidal L, Aguirre M, Fonseca BD, van Kempen LC, Alain T, Larsson O, Jaramillo M. 2018. The protozoan parasite Toxoplasma gondii selectively reprograms the host translatome.1Equal contribution. Infection and Immunity 86: e00244-18. DOI: 10.1128/IAI.00244-18 William M, Leroux LP, Lorent J, Chaparro V, Graber TE, M’Boutchou MN, Charpentier T, Fabié A, Dozois CM, Stäger S, van Kempen LC, Alain T, Larsson O, Jaramillo M. 2018. eIF4E-binding proteins 1 and 2 limit macrophage anti-inflammatory responses through translational repression of Interleukin-10 and Cyclooxygenase-2. The Journal of Immunology 200 :4102-4116. DOI: 10.4049/jimmunol.1701670 Zakaria C, Sean P, Hoang HD, Leroux LP, Watson M, Workenhe ST, Hearnden J, Pearl D, Truong TV, Robichaud N, Yanagiya A, Tahmasebi S, Jafarnejad SM, Jia JJ, Graber TE, Fonseca BD, Pelin A, Diallo JS, Le Boeuf F, Bell JC, Mossman K, Jaramillo M, Sonenberg N, Alain T. 2018. Active-Site mTOR inhibitors augment HSV1 infection of cancer cells with elevated eIF4E activity. PLoS Pathogens 14:  e1007264. DOI: 10.1371/journal.ppat.1007264 Leroux LP, Nasr M, Valanparambil R, Tam M, Rosa BA, Siciliani D, Hill DE, Zarlenga DS, Jaramillo M, Weinstock JV, Geary TG, Stevenson MM, Urban JF, Makedonka M, Jardim A. 2018. Analysis of the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties. Scientific Reports 8:15921. DOI:10.1038/s41598-018-34174-4 Nehdi A, Sean P, Linares I, Colina R, Jaramillo M, Alain T. 2014. Deficiency in either 4E-BP1 or 4E-BP2 augments innate antiviral immune responses. PLoS ONE 9e114854. DOI: 10.1371/journal.pone.0114854 Herdy B1, Jaramillo M1, Svitkin YV, Rosenfeld A, Kobayashi M, Walsh D, Alain T, Robichaud N, Topisirovic I, Furic L,Dowling RJO,Sylvestre A, Rong L, Colina R, Costa-Mattioli M, Fritz JH, Olivier M, Brown E, Mohr I, Sonenberg N. 2012. Translational control of the activation of transcription factor NF-kappaB and production of type I interferon by phosphorylation of the translation factor eIF4E. 1Equal contribution. Nature Immunology  3: 543-50. DOI: 10.1038/ni.2291 Jaramillo M, Gomez MA, Larsson O, Shio MT, Topisirovic I, Contreras I, Luxenburg R, Rosenfeld A, Colina R, McMaster R, Olivier M, Costa-Mattioli M, Sonenberg N. 2011. Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection.  Cell Host & Microbe 9: 331-41. DOI: 10.1016/j.chom.2011.03.008 Colina R1, Costa-Mattioli M1, Dowling RJ, Jaramillo M, Tai LH, Breitbach CJ, Martineau Y, Larsson O, Rong L, Svitkin YV, Makrigiannis AP, Bell JC, Sonenberg N. 2008. Translational control of the innate immune response through IRF-7. Nature 452:323-28. 1Equal contribution. DOI: 10.1038/nature06730  Present Laboratory Members Research AssociateDr. Louis-Philippe Leroux PhD StudentsVisnú ChaparroAndrés Felipe Díez MejíaAurore Lebourg   Past Laboratory Members Postdoctoral FellowsDr. Jennifer RaischDr. Noushin Saljoughian PhD StudentsSophie ChagneauMirtha WilliamAude Zimmermann Summer StudentsVeronica BellissimoRachel FournierAlex IssaElisabeth RousselAudre-Anne St-YvesMaria Fernanda Torres Research AssistantsNilson Quintana, MScMirana Rakotomanga, MSc  Research AssociatesDr. Pierre-Alexandre RochetteDr. Ronan Rouxel  Interviews and Media Relations INRS: la multidisciplinarité au service de la lutte contre la toxoplasmose.  Journal Le Devoir 05 -10 -2019https://www.ledevoir.com/societe/education/563909/inrs-la-multidisciplinarite-au-service-de-la-lutte-contre-la-toxoplasmose