{"version":"1.0","provider_name":"INRS","provider_url":"https:\/\/inrs.ca\/en\/","author_name":"inrsadmin","author_url":"https:\/\/inrs.ca\/en\/author\/inrsadmin\/","title":"Angela Pearson","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"5owZds3KYR\"><a href=\"https:\/\/inrs.ca\/en\/research\/professors\/angela-pearson\/\">Angela Pearson<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/inrs.ca\/en\/research\/professors\/angela-pearson\/embed\/#?secret=5owZds3KYR\" width=\"600\" height=\"338\" title=\"&#8220;Angela Pearson&#8221; &#8212; INRS\" data-secret=\"5owZds3KYR\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/* ]]> *\/\n<\/script>\n","thumbnail_url":"https:\/\/inrs.ca\/wp-content\/uploads\/Angela-Pearson9939_JLecompte_H_72DPI_Profil-scaled.jpg","thumbnail_width":2560,"thumbnail_height":1707,"description":"BiographyProfessor Angela Pearson obtained her B.Sc. in Microbiology and Immunology from McGill University, and her Ph.D. in Molecular and Medical Genetics from the University of Toronto.\u00a0 After a postdoctoral fellowship in virology in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School, Dr. Pearson joined the faculty at INRS-Institut Armand-Frappier in 2004.\u00a0 She is a former Research Scholar of the Fonds de recherche du Qu\u00e9bec - Sant\u00e9.\u00a0 She is an Associate Professor in the research axe of Infectious diseases, immunity, cancer, and epidemiology.\u00a0Research in her group is focused on the biology of herpesviruses including the human pathogen herpes simplex virus (HSV) and the veterinary pathogen Canid herpesvirus 1 (CHV-1). HSV infections can be particularly harmful to those with weakened immune systems such as immunosuppressed transplant recipients or those living with AIDS, as well as to newborns due to their immature immune system. In her laboratory, a combination of molecular and cell biological strategies are used to address the following research aims:\u00a0 1) to elucidate the role of viral genes, in particular the highly conserved UL24 gene, in HSV replication and pathogenesis; 2) to understand the the role of nucleolar proteins during HSV infection.\u00a0 The laboratory has shown that the nucleolar protein Upstream Binding Factor (UBF) inhibits HSV replication. Present work is aimed at understanding the mechanisms involved and at identifying the viral protein(s) that counter UBFs inhibitory activity to allow viral replication in the presence of UBF.\u00a0 The laboratory's research program on CHV-1 is focused on understanding virus-host cell interaction.\u00a0 In particular, work is aimed at identifying the entry pathways for CHV-1 into host cells as well as understanding the impact of CHV-1 on cellular miRNAs of the host.\u00a0Professor Pearson is a member of the Centre of Excellence in Orphan Disease Research - Courtois Foundation (CERMO-FC).https:\/\/www.cermofc.uqam.ca\/\u00a0Research in her laboratory is funded by grants from the National Sciences and Engineering Research Council of Canada (NSERC), the Canadian Institutes of Health Research (CIHR), and the Canada Foundation for Innovation (CFI)."}