{"version":"1.0","provider_name":"INRS","provider_url":"https:\/\/inrs.ca\/en\/","author_name":"inrsadmin","author_url":"https:\/\/inrs.ca\/en\/author\/inrsadmin\/","title":"Julien van Grevenynghe","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"eFAIwPsgLJ\"><a href=\"https:\/\/inrs.ca\/en\/research\/professors\/julien-van-grevenynghe\/\">Julien van Grevenynghe<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/inrs.ca\/en\/research\/professors\/julien-van-grevenynghe\/embed\/#?secret=eFAIwPsgLJ\" width=\"600\" height=\"338\" title=\"&#8220;Julien van Grevenynghe&#8221; &#8212; INRS\" data-secret=\"eFAIwPsgLJ\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/* ]]> *\/\n<\/script>\n","thumbnail_url":"https:\/\/inrs.ca\/wp-content\/uploads\/2020\/04\/Julien_Van-Grevenynghe_0492.jpg","thumbnail_width":900,"thumbnail_height":707,"description":"Int\u00e9r\u00eats de recherche Bien que les traitements antir\u00e9troviraux actuels permettent de survivre \u00e0 l\u2019infection au VIH-1, ils sont n\u00e9anmoins associ\u00e9s avec une multitude d\u2019effets secondaires ind\u00e9sirables. De plus, les traitements antir\u00e9troviraux restent inefficaces pour \u00e9liminer compl\u00e8tement le virus de l\u2019organisme, ainsi que l\u2019inflammation r\u00e9siduelle qui persiste chez ces patients. De ce fait, les patients sous traitements continuent \u00e0 pr\u00e9senter des perturbations m\u00e9taboliques et mol\u00e9culaires, qui participent \u00e0 un affaiblissement de leur protection immunitaire. Pour pouvoir un jour pr\u00e9tendre \u00e0 arr\u00eater ces traitements, il faut en premier trouver le moyen d\u2019interf\u00e9rer avec des voies mol\u00e9culaires afin de renforcer cette protection immunitaire. Mon groupe de recherche vise \u00e0 identifier les m\u00e9canismes cellulaires qui sont responsable de la survie r\u00e9duite de la m\u00e9moire T que l\u2019on retrouve chez les patients infect\u00e9s.\u00a0Notre travail inclue \u00e9galement l\u2019\u00e9tude des \u00e9lites contr\u00f4leurs, un groupe unique de patients infect\u00e9s au VIH-1 poss\u00e9dant une capacit\u00e9 naturelle \u00e0 coexister avec le virus. Comprendre les m\u00e9canismes responsables d\u2019une telle protection sans intervention m\u00e9dicale est un outil de choix pour mettre au point de nouvelle strat\u00e9gies th\u00e9rapeutiques chez les autres groupes de patients.\u00a0Notre laboratoire utilise des techniques exp\u00e9rimentales de pointes comme la cytom\u00e9trie de flux multiparam\u00e9triques et Imaging, ainsi que l\u2019analyseur de flux m\u00e9tabolique Seahorse.\u00a0\u00a0\u00a0\u00a0Research interestIn addition to metabolic disturbances, modern antiretroviral therapy (ART) is unable to counteract immune defects that are associated with residual inflammation alongside viral persistence. To eventually achieve ART termination, it is critical to find new ways to boost protective immunity which includes the restoration of long-lasting memory T-cells in HIV-1-infected patients. In this context, my research group concentrates his work on the characterization of molecular and metabolic disturbances that are responsible for defective T-cell-mediated immunity in HIV-1-infected patients.\u00a0\u00a0\u00a0Our work also includes the use of a rare group of naturally protected individuals, called the elite controllers.\u00a0\u00a0Understanding the molecular mechanisms driving the natural protection against VIH-1 is a powerful tool for the design of targeting therapies in the other groups of infected patients.\u00a0\u00a0Of note, our laboratory employs several modern experimental approaches including multi-parameter and imaging flow cytometry as well as Seahorse metabolic flux analyser."}