{"version":"1.0","provider_name":"INRS","provider_url":"https:\/\/inrs.ca\/en\/","author_name":"inrsadmin","author_url":"https:\/\/inrs.ca\/en\/author\/inrsadmin\/","title":"Marie-Claude Rousseau","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"0haOsPJeHU\"><a href=\"https:\/\/inrs.ca\/en\/research\/professors\/marie-claude-rousseau\/\">Marie-Claude Rousseau<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/inrs.ca\/en\/research\/professors\/marie-claude-rousseau\/embed\/#?secret=0haOsPJeHU\" width=\"600\" height=\"338\" title=\"&#8220;Marie-Claude Rousseau&#8221; &#8212; INRS\" data-secret=\"0haOsPJeHU\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/* ]]> *\/\n<\/script>\n","thumbnail_url":"https:\/\/inrs.ca\/wp-content\/uploads\/Marie-Claude-Rousseau0004_JLecompte_H_72DPI_Profil-scaled.jpg","thumbnail_width":2560,"thumbnail_height":1706,"description":"BiographyDr. Marie-Claude Rousseau obtained a bachelor's degree (B.Sc.) in biochemistry from Universit\u00e9 du Qu\u00e9bec a Montr\u00e9al in 1991. Her graduate studies were conducted at McGill University, where she earned a M.Sc. (1998) and Ph.D. (2003) in Epidemiology & Biostatistics.\u00a0With a postdoctoral fellowship from the National Cancer Institute of Canada, she joined Dr Jack Siemiatycki 's research chair in Environmental Epidemiology and Population Health at Universit\u00e9 de Montr\u00e9al's Department of social and preventive medicine (2003-2004). In 2005, she joined INRS-Institut Armand-Frappier as a Professor.\u00a0Her research activities, funded by the Canadian Institutes for Health Research (CIHR), the Canadian Cancer Society, the Multiple Sclerosis Society of Canada, and the Fonds de recherche du Qu\u00e9bec - Sant\u00e9 (FRQS), consist in epidemiological studies on the etiology of inflammatory and autoimmune diseases (asthma, diabetes, multiple sclerosis, inflammatory bowel disease, and cancer).\u00a0Her work focuses on three main themes related to these diseases:the study of factors influencing the immune response and their role in etiologythe study of lifestyle and environmental exposures as potential risk or protective factorsthe evaluation of health services utilization\u00a0Research Interests~~~~~~~~~~~~~~~~~~~~~Studying inflammatory bowel disease etiology: a life course approachCollaborators :\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Pr\u00e9vost\u00a0 Jantchou, CHU Sainte-Justine, co-principal investigator\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Andrea Benedetti, McGill University\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Sylvie Girard, CHU Sainte-JustineSreenath Madathil, McGill UniversityBelinda Nicolau, McGill UniversityShu Qin Wei, CHU Sainte-Justine\u00a0Funding\/partnership :Canadian Institutes of Health Research (2018-2022)Institut de la statistique du Qu\u00e9bec (2019-2020)\u00a0Inflammatory bowel disease is a chronic disease of the gut. It affects digestion and absorption of food, and elimination of waste. Its causes are unknown. After many studies, researchers have only been able to identify a few risk factors with certainty. They include family history of the disease and cigarette smoking. The causes of this disease are still unknown, but some researchers think that certain times in life could be more critical for the development of the disease.\u00a0Our goal is to clarify the causes of disease, and identify which ones could be targeted by prevention program. We are studying medical, environmental, lifestyle, and psychosocial factors from the time of birth until adult years to determine if they are linked to the development of the disease. These factors are for example: prematurity, breastfeeding, antibiotic use, diet, smoking, stress. We also study carefully when these factors occur during a person\u2019s life. For this research, we are using a cohort of about 400,000 persons born between 1970 and 1974, in the province of Quebec. We created this cohort by linking together some provincial administrative databases. Data on medical services and hospitalizations for inflammatory bowel disease were obtained until 2014 and have been used to determine who is affected by the disease. We will ask about 2600 persons of the cohort to complete a web survey to collect information on the factors of interest. Among the participants, we will compare persons who have the disease to those who do not, and evaluate what are the key moments throughout their lives when these factors could affect the risk of the disease.\u00a0This research will help understanding which factors increase the risk of inflammatory bowel disease by detecting if there are certain times in a person\u2019s life that are especially important for etiology. This will allow us to generate crucial information to establish prevention programs.\u00a0~~~~~~~~~~~~~~~~~~~~~Potential health effects from non-specific stimulation of the immune system in early age through vaccination with Bacille Calmette-Gu\u00e9rin (BCG)\u00a0Project on lymphomaCollaborators:Andrea Benedetti, McGill UniversityMarie-\u00c9lise Parent, INRS\u00a0Funding:Canadian Cancer Society\u00a0(2015-2018)\u00a0Project on Multiple SclerosisCollaborators:\u00a0Christina Wolfson, McGill UniversityAndrea Benedetti, McGill UniversityNathalie Arbour, CHUM, Universit\u00e9 de Montr\u00e9alPierre Duquette, CHUM, Universit\u00e9 de Montr\u00e9alMarie-\u00c9lise Parent, INRS\u00a0Funding:Multiple Sclerosis Society of Canada\u00a0(2015-2018)Canadian Institutes of Health Research\u00a0(2015-2016)\u00a0Several studies have suggested a possible link between vaccination, childhood infections and the development of the immune system. The BCG vaccine stimulates macrophages, which in turn induce the production of cytokines by TH1 lymphocytes. Epidemiological results on the health effects of BCG vaccination are contradictory. Some studies have suggested a decreased incidence of asthma, allergies, and type-1 diabetes among vaccinated individuals. The BCG vaccine has been suggested as a potential preventive factor against leukemia and melanoma, but as a risk factor for non-Hodgkin's lymphoma and Hodgkin's disease.\u00a0A BCG vaccination program took place in Quebec from 1949 to 1974, initiated by Dr Armand Frappier himself. The vaccination certificates for the entire province were sent to the central registry, still kept at Centre Armand-Frappier Sant\u00e9 Biotechnologie within INRS. The registry was computerized through a grant from the Canada Foundation for Innovation (Leaders Opportunity Fund). The overall objective of these projects is to determine whether a non-specific stimulation of the immune system in early life, as resulting from BCG vaccination, is associated with beneficial or adverse health effects. The BCG vaccination registry is a unique resource with enormous potential to answer questions about the potential off-target effects of this vaccine. We have demonstrated the feasibility and validity of linking this data source to administrative databases available in Quebec [birth and death registries, Med-\u00c9cho (hospitalizations), RAMQ (medical services)].\u00a0Our current work will open the door to studies focusing on the link between immunity, infections, and several chronic diseases. The information acquired thereof will go way beyond the BCG vaccination itself. It has the potential to provide leads into a better understanding of the role of immunostimulation early in life and of mechanistic processes involved in the development of chronic diseases characterized by an inflammatory or autoimmune process.\u00a0~~~~~~~~~~~~~~~~~~~~~\u00a0Workplace exposures and prostate cancer: analysis and reporting on a Canadian population-based studyCollaborators:Marie-Elise Parent, INRS, Principal InvestigatorPaul Demers, Occupational Cancer Research CenterJ\u00e9r\u00f4me Lavou\u00e9, Universit\u00e9 de Montr\u00e9alMarie-Claude Rousseau, INRSAndrea Benedetti, McGill UniversityCheryl Peters, Alberta Health Services\u00a0Funding:Canadian Institutes of Health Research (2018-2022)\u00a0Rationale: Each year, 21,000 Canadian men are diagnosed with prostate cancer (PCa). About 30% of these are aggressive but diagnosis and treatment of non-aggressive ones seriously impact quality of life. Age, ancestry and family history are the only established risk factors while genetics explain only a proportion of familial cases. There is compelling evidence that environmental factors play a role, but modifiable risk factors have yet to be identified so prevention has not been possible. Other than for pesticides, very little research has been conducted on environmental chemicals in PCa etiology. Several chemicals are themselves carcinogens or act as hormone modulators, and could be implicated. The workplace represents a preferential window to study these since many are encountered there at higher levels, facilitating their measurement. Since most workplace chemicals eventually make their way into the general environment, such exposures are not only relevant to workers but also to the entire population. The absence of large occupational studies benefiting from strong exposure assessment has been the major drawback to advancing knowledge in this area. In 2002-2015, Canadian funding agencies funded what is to our knowledge the largest and most comprehensive population-based study of PCa, to assess the etiological role of workplace exposures. The occupational assessment was completed, as planned, in late 2015, coinciding with the end of funding, and it was anticipated that new funding would need to be secured for primary analyses.\u00a0Broad goal: To investigate whether different exposures measured in the workplace increase the risk of developing PCa.\u00a0Methods: 1,933 cases, including 538 aggressive cancers, were ascertained from Montreal metropolitan area hospitals. Concomitantly, 1,994 population controls were selected from electoral lists. Face-to-face interviews collected information on socio-demographic, lifestyle and medical factors, including screening. We documented each job held by each subject over his lifetime, eliciting details on specific tasks, equipment used, etc. This wealth of occupational information (15,724 job descriptions) has been coded by a team of chemists\/industrial hygienists into lifetime exposure to hundreds of chemicals.\u00a0Aims: This protocol outlines 19 analytical subprojects to be undertaken over the course of the grant. It focuses on suspected exposures with hormone-modulating properties and\/or previous evidence such as polycyclic aromatic hydrocarbons, petroleum-derived liquids, engine emissions and combustion products, solvents, welding fumes, resins and polymers, metals, painting-related chemicals, and pesticides. Other projects focus on night work and on physical activity\/inactivity at work. Exposures will be analysed individually and combined, taking into account co-exposures, confounding and interactions.\u00a0Significance\/application: This project, representing a major advance in the field, will generate important new knowledge towards the establishment of preventive measures against PCa."}