{"version":"1.0","provider_name":"INRS","provider_url":"https:\/\/inrs.ca\/en\/","author_name":"inrsadmin","author_url":"https:\/\/inrs.ca\/en\/author\/inrsadmin\/","title":"Maritza Jaramillo","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"zo3Jn973wG\"><a href=\"https:\/\/inrs.ca\/en\/research\/professors\/maritza-jaramillo\/\">Maritza Jaramillo<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/inrs.ca\/en\/research\/professors\/maritza-jaramillo\/embed\/#?secret=zo3Jn973wG\" width=\"600\" height=\"338\" title=\"&#8220;Maritza Jaramillo&#8221; &#8212; INRS\" data-secret=\"zo3Jn973wG\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/* ]]> *\/\n<\/script>\n","thumbnail_url":"https:\/\/inrs.ca\/wp-content\/uploads\/Maritza-Jaramillo-0045_JLecompte_H_72DPI_Profil-scaled.jpg","thumbnail_width":2560,"thumbnail_height":1707,"description":"\u00a0Biography\u00a0Dr. Maritza Jaramillo received her undergraduate degree in Biology from Universidad Nacional de Colombia (Bogot\u00e1, Colombia). Subsequently, she completed her MSc and PhD in Microbiology and Immunology at Universit\u00e9 Laval (Quebec, QC, Canada) under the supervision of Dr. Martin Olivier. During his graduate studies, Dr. Jaramillo worked on the transcriptional regulation of pro-inflammatory molecules induced during protozoan parasitic infections. Subsequently, she began her postdoctoral research in Dr. Nahum Sonenberg's laboratory at McGill University (Montreal, QC, Canada), where she worked on translational control of infectious diseases. In May 2012 Dr. Jaramillo joined the Faculty of INRS -\u00a0Centre Armand-Frappier Sant\u00e9 Biotechnologie (CAFSB)\u00a0 as an Assistant Professor to investigate the mechanisms and the functional consequences of dysregulated mRNA metabolism during toxoplasmosis. In May 2018 Dr. Jaramillo was granted tenure and was promoted to the rank of Associate Professor.\u00a0\u00a0Research Interests\u00a0Congenital toxoplasmosis is an infectious disease caused by Toxoplasma gondii (T. gondii), an obligate intracellular parasite commonly transmitted to humans by ingestion of contaminated raw meat, water, or soil. During pregnancy, T. gondii infection can lead to miscarriage, premature births, or serious birth defects (e.g. blindness, hydrocephalus, and mental retardation). It is estimated that ~30-40% of the world population is seropositive and that >90% of women in childbearing age are at risk of contractingthe parasite. Unfortunately, efficient and safe vaccines are lacking and available treatments often display teratogenic side effects. Hence, it has become critical to understand the molecular mechanisms underlying the interactions between T. gondii and the infected patient, particularly at the mother\/fetus interface. In light of this problem, Dr. Jaramillo\u2019s group investigates how dysregulation of host mRNA turnover and protein synthesis during T. gondii infection contributes to disrupt normal functions of placental cell populations including resident macrophages and trophoblasts, which are essential for embryo implantation and fetal development. Her studies also rely on the use of clinical samples from infected pregnant women and the ex vivo model of placental explants obtained from healthy donors. These valuable resources help validate data obtained in vitro\u00a0and assess the implications of such findings in a clinical setting. Dr. Jaramillo\u2019s long-term goal is to advance our understanding of the biological underpinnings implicated during congenital toxoplasmosis and to devise ways to thwart T. gondii replication and transmission. Ultimately, she wishes to provide insight into the pathogenesis of clinically relevant infectious organisms and to pave the way to safer therapies to prevent illnesses and promote healthy pregnancies.\u00a0\u00a0Research Funding\u00a0Currently, Dr. Jaramillo's research program is funded by a CIHR Project Grant (OCT\/2019 - SEP\/2024) and an NSERC Discovery Grant (APR\/2019 - MAR\/2024).\u00a0\u00a0Selected Publications\u00a0Hoang HD1, Graber TE1, Jia JJ, Vaidya N, Gilchrist V, Li W, Gkogkas CG, Jaramillo M, Jafarnejad SM, Alain, T.\u00a02019. Induction of an alternative 5\u2019 leader enhances translation of\u00a0Inpp5e\u00a0and resistance to oncolytic virus infection.\u00a01Equal contribution.\u00a0Cell Reports\u00a029:4010-4023\u00a0doi.org\/10.1016\/j.celrep.2019.11.072\u00a0William M1, Leroux LP1, Chaparro V, Graber TE, Alain T, Jaramillo M.\u00a02019. Translational repression of\u00a0Ccl5\u00a0and\u00a0Cxcl10\u00a0by 4E-BP1 and 4E-BP2 restrains the ability of mouse macrophages to induce migration of activated T cells.\u00a01Equal contribution.\u00a0European Journal of Immunology. DOI 10.1002\/eji.201847857\u00a0Chaparro V, Leroux LP, Zimmermann A, Jardim A, Johnston B, Descoteaux A, Jaramillo M.\u00a02019.\u00a0Leishmania donovani\u00a0lipophosphoglycan increases macrophage-dependent chemotaxis of CXCR6-expressing cells via CXCL16 induction.\u00a0Infection and Immunity\u00a087:e00064-19.\u00a0DOI\u00a010.1128\/IAI.00064-19\u00a0Atayde V, da Silva Lira Filho A, Chaparro V, \u00a0Zimmermann A, Jaramillo M, Olivier M.\u00a02019.\u00a0Leishmania\u00a0RNA Virus 1 exploits the\u00a0Leishmania\u00a0exosomal pathway for successful propagation and infection.\u00a0Nature Microbiology\u00a0DOI:\u00a010.1038\/s41564-018-0352-y\u00a0Leroux LP, Lorent J1, Graber TE1, Chaparro V, Masvidal L, Aguirre M, Fonseca BD, van Kempen LC, Alain T, Larsson O, Jaramillo M.\u00a02018. The protozoan parasite\u00a0Toxoplasma gondii\u00a0selectively reprograms the host translatome.1Equal contribution.\u00a0Infection and Immunity\u00a086: e00244-18. DOI: 10.1128\/IAI.00244-18\u00a0William M, Leroux LP, Lorent J, Chaparro V, Graber TE, M\u2019Boutchou MN, Charpentier T, Fabi\u00e9 A, Dozois CM, St\u00e4ger S, van Kempen LC, Alain T, Larsson O, Jaramillo M.\u00a02018. eIF4E-binding proteins 1 and 2 limit macrophage anti-inflammatory responses through translational repression of Interleukin-10 and Cyclooxygenase-2.\u00a0The Journal of Immunology\u00a0200 :4102-4116. DOI: 10.4049\/jimmunol.1701670\u00a0Zakaria C, Sean P, Hoang HD, Leroux LP, Watson M, Workenhe ST, Hearnden J, Pearl D, Truong TV, Robichaud N, Yanagiya A, Tahmasebi S, Jafarnejad SM, Jia JJ, Graber TE, Fonseca BD, Pelin A, Diallo JS, Le Boeuf F, Bell JC, Mossman K, Jaramillo M, Sonenberg N, Alain T.\u00a02018. Active-Site mTOR inhibitors augment HSV1 infection of cancer cells with elevated eIF4E activity.\u00a0PLoS Pathogens\u00a014:\u00a0 e1007264. DOI: 10.1371\/journal.ppat.1007264\u00a0Leroux LP, Nasr M, Valanparambil R, Tam M, Rosa BA, Siciliani D, Hill DE, Zarlenga DS, Jaramillo M, Weinstock JV, Geary TG, Stevenson MM, Urban JF, Makedonka M, Jardim A.\u00a02018. Analysis of the\u00a0Trichuris suis\u00a0excretory\/secretory proteins as a function of life cycle stage and their immunomodulatory properties.\u00a0Scientific Reports\u00a08:15921. DOI:10.1038\/s41598-018-34174-4\u00a0Nehdi A, Sean P, Linares I, Colina R, Jaramillo M, Alain T.\u00a02014. Deficiency in either 4E-BP1 or 4E-BP2 augments innate antiviral immune responses.\u00a0PLoS ONE\u00a09e114854. DOI: 10.1371\/journal.pone.0114854\u00a0Herdy B1, Jaramillo M1, Svitkin YV, Rosenfeld A, Kobayashi M, Walsh D, Alain T, Robichaud N, Topisirovic I, Furic L,Dowling RJO,Sylvestre A, Rong L, Colina R, Costa-Mattioli M, Fritz JH, Olivier M, Brown E, Mohr I, Sonenberg N.\u00a02012. Translational control of the activation of transcription factor NF-kappaB and production of type I interferon by phosphorylation of the translation factor eIF4E.\u00a01Equal contribution.\u00a0Nature Immunology\u00a0 3: 543-50. DOI: 10.1038\/ni.2291\u00a0Jaramillo M, Gomez MA, Larsson O, Shio MT, Topisirovic I, Contreras I, Luxenburg R, Rosenfeld A, Colina R, McMaster R, Olivier M, Costa-Mattioli M, Sonenberg N.\u00a02011.\u00a0Leishmania\u00a0repression of host translation through mTOR cleavage is required for parasite survival and infection.\u00a0\u00a0Cell Host & Microbe\u00a09: 331-41. DOI: 10.1016\/j.chom.2011.03.008\u00a0Colina R1, Costa-Mattioli M1, Dowling RJ, Jaramillo M, Tai LH, Breitbach CJ, Martineau Y, Larsson O, Rong L, Svitkin YV, Makrigiannis AP, Bell JC, Sonenberg N.\u00a02008. Translational control of the innate immune response through IRF-7.\u00a0Nature\u00a0452:323-28.\u00a01Equal contribution. DOI: 10.1038\/nature06730\u00a0\u00a0Present Laboratory Members\u00a0Research AssociateDr. Louis-Philippe Leroux\u00a0PhD StudentsVisn\u00fa ChaparroAndr\u00e9s Felipe D\u00edez Mej\u00edaAurore Lebourg\u00a0\u00a0\u00a0Past Laboratory Members\u00a0Postdoctoral FellowsDr. Jennifer RaischDr. Noushin Saljoughian\u00a0PhD StudentsSophie ChagneauMirtha WilliamAude Zimmermann\u00a0Summer StudentsVeronica BellissimoRachel FournierAlex IssaElisabeth RousselAudre-Anne St-YvesMaria Fernanda Torres\u00a0Research AssistantsNilson Quintana, MScMirana Rakotomanga, MSc\u00a0\u00a0Research AssociatesDr. Pierre-Alexandre RochetteDr. Ronan Rouxel\u00a0\u00a0Interviews and Media Relations\u00a0INRS: la multidisciplinarit\u00e9 au service de la lutte contre la toxoplasmose.\u00a0\u00a0Journal Le Devoir 05 -10 -2019https:\/\/www.ledevoir.com\/societe\/education\/563909\/inrs-la-multidisciplinarite-au-service-de-la-lutte-contre-la-toxoplasmose\u00a0\u00a0\u00a0"}