{"id":195709,"date":"2025-06-20T06:30:00","date_gmt":"2025-06-20T10:30:00","guid":{"rendered":"https:\/\/inrs.ca\/?p=195709"},"modified":"2025-06-20T08:53:14","modified_gmt":"2025-06-20T12:53:14","slug":"biomarkers-and-new-therapeutic-strategies-to-better-treat-brain-cancer","status":"publish","type":"post","link":"https:\/\/inrs.ca\/en\/news\/biomarkers-and-new-therapeutic-strategies-to-better-treat-brain-cancer\/","title":{"rendered":"Biomarkers and New Therapeutic Strategies to Better Treat Brain Cancer\u00a0"},"content":{"rendered":"\n<p class=\"has-large-font-size wp-block-paragraph\"><strong>INRS researcher awarded $1.2M to advance glioblastoma research<\/strong>.<\/p>\n\n\n    \n<div class=\"wp-block full-width-image fixed-height\">\n    <div class=\"image-ctn\">\n        <img decoding=\"async\" src=\"https:\/\/inrs.ca\/wp-content\/uploads\/Maya-saleh-inrs-web.jpg\" alt=\"\" \/>\n    <\/div>\n    <p><\/p>\n<\/div>\n\n\n<p class=\"has-drop-cap wp-block-paragraph\">Professor <a href=\"https:\/\/inrs.ca\/en\/research\/professors\/maya-saleh\/\" target=\"_blank\" rel=\"noreferrer noopener\">Maya Saleh<\/a>, a world-renowned expert in immuno-oncology at the Institut national de la recherche scientifique (INRS), and her team have received a major $1.2 million grant from the <a href=\"https:\/\/cihr-irsc.gc.ca\/e\/193.html\" target=\"_blank\" rel=\"noreferrer noopener\">Canadian Institutes of Health Research (CIHR)<\/a>. Their goal: to better understand glioblastoma, an especially aggressive and deadly form of brain cancer.&nbsp;<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u201cThe average survival rate for patients diagnosed with glioblastoma is only 12 to 14 months. Treatments have barely evolved in the past 40 years. It is therefore crucial to explore new therapeutic avenues and challenge the grim prognosis of this disease.\u201d&nbsp;<\/p>\n<cite><strong>Maya Saleh<\/strong>, Professor at INRS&nbsp;<\/cite><\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">Spanning five years, this research aims to identify biomarkers that will help tailor treatments, enhance immune responses, and increase the number of patients who can benefit from long-lasting immunotherapy.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-mapping-the-brain-s-immune-landscape-nbsp\">Mapping the brain\u2019s immune landscape&nbsp;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The current standard treatment for glioblastoma includes surgery followed by radiation and chemotherapy. However, the cancer recurs in over 90% of cases. Existing immunotherapies are often ineffective because they primarily target T cells\u2014specialized immune cells that have limited access to the brain. Instead, the brain is heavily infiltrated by another type of immune cell called monocytes, which can promote tumor growth.&nbsp;<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;galleryId&quot;:&quot;6a97c713299f4&quot;}\" data-wp-interactive=\"core\/gallery\" class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-2 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6a97c71329fca&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"6a97c71329fca\" class=\"wp-block-image size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on--pointerdown=\"actions.preloadImage\" data-wp-on--pointerenter=\"actions.preloadImageWithDelay\" data-wp-on--pointerleave=\"actions.cancelPreload\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" data-id=\"195706\" src=\"https:\/\/inrs.ca\/wp-content\/uploads\/AFSB-inrs-cr_Josee_Lecompte-1024x683.jpg\" alt=\"\" class=\"wp-image-195706\" srcset=\"https:\/\/inrs.ca\/wp-content\/uploads\/AFSB-inrs-cr_Josee_Lecompte-1024x683.jpg 1024w, https:\/\/inrs.ca\/wp-content\/uploads\/AFSB-inrs-cr_Josee_Lecompte-300x200.jpg 300w, https:\/\/inrs.ca\/wp-content\/uploads\/AFSB-inrs-cr_Josee_Lecompte-768x512.jpg 768w, https:\/\/inrs.ca\/wp-content\/uploads\/AFSB-inrs-cr_Josee_Lecompte-1536x1025.jpg 1536w, https:\/\/inrs.ca\/wp-content\/uploads\/AFSB-inrs-cr_Josee_Lecompte-2048x1366.jpg 2048w, https:\/\/inrs.ca\/wp-content\/uploads\/AFSB-inrs-cr_Josee_Lecompte-600x400.jpg 600w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\tdata-wp-bind--aria-label=\"state.thisImage.triggerButtonAriaLabel\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.thisImage.buttonRight\"\n\t\t\tdata-wp-style--top=\"state.thisImage.buttonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Armand-Frappier Sant\u00e9 Biotechnologie Research Centre<\/figcaption><\/figure>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6a97c7132a364&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"6a97c7132a364\" class=\"wp-block-image size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"536\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on--pointerdown=\"actions.preloadImage\" data-wp-on--pointerenter=\"actions.preloadImageWithDelay\" data-wp-on--pointerleave=\"actions.cancelPreload\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" data-id=\"195703\" src=\"https:\/\/inrs.ca\/wp-content\/uploads\/Maya-Saleh-INRS_web-20240131-1024x536.jpg\" alt=\"\" class=\"wp-image-195703\" srcset=\"https:\/\/inrs.ca\/wp-content\/uploads\/Maya-Saleh-INRS_web-20240131-1024x536.jpg 1024w, https:\/\/inrs.ca\/wp-content\/uploads\/Maya-Saleh-INRS_web-20240131-300x157.jpg 300w, https:\/\/inrs.ca\/wp-content\/uploads\/Maya-Saleh-INRS_web-20240131-768x402.jpg 768w, https:\/\/inrs.ca\/wp-content\/uploads\/Maya-Saleh-INRS_web-20240131.jpg 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\tdata-wp-bind--aria-label=\"state.thisImage.triggerButtonAriaLabel\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.thisImage.buttonRight\"\n\t\t\tdata-wp-style--top=\"state.thisImage.buttonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">At the <a href=\"https:\/\/inrs.ca\/en\/inrs\/research-centres\/armand-frappier-sante-biotechnologie-research-centre\/\" target=\"_blank\" rel=\"noreferrer noopener\">INRS Armand-Frappier Sant\u00e9 Biotechnologie Research Centre<\/a>, Professor Saleh\u2019s team is working to map the immune landscape of the brain in glioblastoma patients. Their research focuses on targeting myeloid cells (monocytes and their derivatives), which contribute to tumor progression and therapy resistance.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cOne of our key research goals is to study how surgery affects the brain\u2019s immune environment. We hypothesize that surgery may paradoxically promote tumor recurrence by amplifying the harmful activity of tumor-associated monocytes,\u201d explains Professor Saleh.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Surgical intervention triggers tissue inflammation, which can feed tumor-initiating cells that often cause recurrence at the site of the original tumor resection.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-valuable-clinical-collaborations-nbsp\">Valuable clinical collaborations&nbsp;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">To validate their findings, Professor Saleh\u2019s team collaborates with Drs. <a href=\"https:\/\/www.chumontreal.qc.ca\/en\/crchum\/chercheurs\/sami-obaid\" target=\"_blank\" rel=\"noreferrer noopener\">Sami Obaid<\/a> and <a href=\"https:\/\/www.chumontreal.qc.ca\/en\/crchum\/chercheurs\/romain-cayrol\" target=\"_blank\" rel=\"noreferrer noopener\">Romain Cayrol<\/a> from the Department of Neurosurgery and Neuropathology at the CHUM (Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al). They analyze rare biopsies collected from patients who undergo a second surgery within 48 hours of the initial procedure.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cUnderstanding the impact of surgery on glioblastoma progression is essential to adapting our therapeutic, medical, and surgical approaches to improve outcomes for patients facing this devastating disease,\u201d says Dr. Sami Obaid, neurosurgeon at the CHUM.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The collected tissues are analyzed using cutting-edge technologies, including spatial biology\u2014a powerful tool that reveals complex cellular and molecular interactions in their native context. INRS is the only institution in Canada equipped with this technology, which has been funded by the Canada Foundation for Innovation (CFI).&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mass spectrometry imaging is also used to study tissue metabolites, in collaboration with coresearcher Professor <a href=\"https:\/\/chimie.umontreal.ca\/english\/department-directory\/professors\/professor\/in\/in15219\/sg\/Pierre%20Chaurand\/\">Pierre Chaurand<\/a> at the Universit\u00e9 de Montr\u00e9al. This approach allows researchers to examine how glucose, lipids, and other compounds influence the tumor microenvironment.\u00a0<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-artificial-intelligence-empowering-data-analysis-nbsp\">Artificial intelligence empowering data analysis&nbsp;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The team also benefits from the expertise of Professor <a href=\"https:\/\/inrs.ca\/en\/research\/professors\/amadou-barry\/\" target=\"_blank\" rel=\"noreferrer noopener\">Amadou Barry<\/a>, a biostatistician at INRS and member of the joint INRS-UQAC research unit in sustainable health. Professor Barry, who is also collaborating as a co-researcher on this project, develops artificial intelligence algorithms to analyze the complex data generated by spatial biology.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThis unique collaboration enables us to identify cellular and molecular signatures associated with tumor subtypes and immune responses, helping to advance precision medicine in brain cancer treatment,\u201d says Professor Barry.&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>INRS researcher awarded $1.2M to advance glioblastoma research.<\/p>\n","protected":false},"author":4,"featured_media":195712,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[688],"tags":[],"sectors":[679],"class_list":["post-195709","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innover-a-linrs-en","sectors-sante-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.1 (Yoast SEO v28.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Biomarkers and New Therapeutic Strategies to Better Treat Brain Cancer\u00a0 | INRS | News<\/title>\n<meta name=\"description\" content=\"INRS researcher awarded $1.2M to advance glioblastoma research.\" \/>\n<meta name=\"robots\" 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