{"id":85290,"date":"2021-12-22T07:51:17","date_gmt":"2021-12-22T12:51:17","guid":{"rendered":"https:\/\/inrs.ca\/?p=85290"},"modified":"2021-12-22T09:21:34","modified_gmt":"2021-12-22T14:21:34","slug":"developing-bioactive-coatings-for-better-orthopaedic-implants","status":"publish","type":"post","link":"https:\/\/inrs.ca\/en\/news\/developing-bioactive-coatings-for-better-orthopaedic-implants\/","title":{"rendered":"Developing bioactive coatings for better orthopaedic implants"},"content":{"rendered":"\n<p class=\"has-large-font-size wp-block-paragraph\"><strong>An INRS team has developed an implant coating made with and shrimp shells, collagen, and glass to promote healing and lower the risk of rejection. <\/strong><strong><\/strong><\/p>\n\n\n    \n<div class=\"wp-block full-width-image fixed-height\">\n    <div class=\"image-ctn\">\n        <img decoding=\"async\" src=\"https:\/\/inrs.ca\/wp-content\/uploads\/IMplantRosei-Web-PL-1.jpg\" alt=\"Orthopedic implant in the hip\" \/>\n    <\/div>\n    <p>The limited bioactive properties of traditional implants can increase the length of the healing process and the risk of rejection.  Photo : Adobe Stock<\/p>\n<\/div>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-drop-cap wp-block-paragraph\">Bioactive coatings play a vital role in the success of implants such as those for knees or hips, because their properties induce a biological response that is good for the health. PhD student Imran Deen and Professor <a href=\"https:\/\/inrs.ca\/en\/research\/professors\/federico-rosei\/\">Federico Rosei<\/a> from Institut national de la recherche scientifique (INRS) are working on a coating that mimics bone tissue.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cTraditional metal, ceramic, or polymer implants have limited bioactive properties. The healing process can be lengthy and have a higher risk of rejection. Developing a new generation of implant materials that promote compatibility and integration is crucial,\u201d said Professor Rosei.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><br><strong>Bioactive materials<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The research team is working on a cutting-edge coating based on three bioactive materials. Chitosan, found in shrimp shells, has antimicrobial properties. Collagen, the organic component of bone, facilitates cell migration and growth. And copper-doped phosphate glass stimulates blood vessel formation and bone reconstruction.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u201cThe ability to deposit such coatings allows for the potential to make implants with tailored biological properties. It holds promise for biomedical applications, as these coatings can provide better implant-host interactions.\u201d<\/p><cite>Ph.D. student Imran Deen<\/cite><\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\"><br><strong>An innovative deposition method<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The team uses electrophoretic deposition to make the coating. The implant acts as an electrode on which bioactive material particles are deposited, forming a layer. The method does not damage the structure and properties of bioactive materials. And unlike other deposition processes currently used, it can be used at standard ambient temperature and pressure on complex shapes without expensive equipment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The process is also versatile since the deposition can be easily adapted to specific applications. For example, the technique can be applied to hydrophilic and antimicrobial coatings, bone surface reconstruction, or coatings that are biologically and chemically inert. The product could be used to produce coronary or venous stents, in bone transplants, or in medical environments to prevent the transmission of bacteria, and thus biological infections.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The next step is to conduct additional studies to validate the proof of concept, particularly biologically. Before this type of coating is used in clinical applications, cell proliferation at the surface of the coating needs to be measured and in vivo tissue adhesion assessed.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><br><strong>About the study<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The article called \u201c<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021979721014338?via=ihub\" target=\"_blank\" rel=\"noreferrer noopener\">Electrophoretic deposition of collagen\/chitosan films with copper-doped phosphate glasses for orthopaedic implants\u2009<\/a>\u201d by Imran Deen, Gurpreet Singh Selopal, Zhiming M. Wang, and Federico Rosei was published in the <em>Journal of Colloid and Interface Science<\/em>. The study received funding from the <a href=\"https:\/\/www.nserc-crsng.gc.ca\/index_eng.asp\" target=\"_blank\" rel=\"noreferrer noopener\">Natural Sciences and Engineering Research Council of Canada<\/a>, the <a href=\"https:\/\/www.chairs-chaires.gc.ca\/home-accueil-eng.aspx\" target=\"_blank\" rel=\"noreferrer noopener\">Canada Research Chairs<\/a>, the <a href=\"https:\/\/inrs.ca\/en\/research\/research-chairs-groups-and-networks\/find-research-chair-group-or-network\/unesco-chair-in-materials-and-technologies-for-energy-conversion-saving-and-storage\/\">UNESCO Chair in Materials and Technologies for Energy Conversion, Conservation and Storage (MATECSS)<\/a>, and the <u><a href=\"https:\/\/en.uestc.edu.cn\/\" target=\"_blank\" rel=\"noreferrer noopener\">University of Electronic Science and Technology of China<\/a>.<\/u><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An INRS team has developed an implant coating made with and shrimp shells, collagen, and glass to promote healing and lower the risk of rejection. <\/p>\n","protected":false},"author":3,"featured_media":85296,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[688],"tags":[],"sectors":[679,731],"class_list":["post-85290","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innover-a-linrs-en","sectors-sante-en","sectors-materiaux-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.1 (Yoast SEO v28.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Developing bioactive coatings for better orthopaedic implants | INRS<\/title>\n<meta name=\"description\" content=\"An INRS team has developed an implant coating to promote healing 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