{"id":20032,"date":"2025-09-29T08:32:00","date_gmt":"2025-09-29T12:32:00","guid":{"rendered":"https:\/\/inrs.ca\/?post_type=project&#038;p=20032"},"modified":"2026-01-30T16:09:51","modified_gmt":"2026-01-30T21:09:51","slug":"structural-and-functional-studies-of-nickel-transporters-from-pathogenic-bacteria-bon","status":"publish","type":"project","link":"https:\/\/inrs.ca\/en\/studies\/masters-and-phd-projects\/find-a-masters-or-phd-project\/structural-and-functional-studies-of-nickel-transporters-from-pathogenic-bacteria-bon\/","title":{"rendered":"Structural and functional studies of nickel transporters from pathogenic bacteria"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-project-description\">Project description<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The ability of pathogenic microorganisms to scavenge essential nutrients within their hosts is a fundamental requirement for pathogenicity. The battle for these nutrients represents an important element of the host \u2013 pathogen interaction; interfering with the nutrient-uptake ability of bacteria represents a promising therapeutic approach. Helicobacter pylori is one of the most successful human pathogens, causing gastric cancers and ulcers. <em>H. pylori <\/em>colonizes the stomach of 50% of the worldwide population where the pathogen survival relies on its ability to scavenge nickel ions from the gastric milieu. Nickel is considered an important virulence determinant of H. pylori; nickel ions are co-factors of two essential <em>H. pylori<\/em> metalloenzymes required for the colonization of its host. Hence, <em>H. pylori <\/em>has acquired a conserved core of dedicated nickel uptake and trafficking proteins unique to this bacterium, that emphasizes its absolute requirement for nickel.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Masters or PhD project consists in investigating the structure-function relationship of the nickel transporters and nickel-homeostasis proteins. The MSc or PhD student will use multidisciplinary approaches combining molecular biology, protein biochemistry, structural biology, electrophysiology and bioinformatics to dissect the molecular mechanism of nickel transport across the outer and inner membranes of the pathogen. Structures of nickel transporters will be helpful in the design of specific inhibitors to treat infections of <em>H. pylori<\/em>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-research-fields\">Research fields<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Structural Biolog<\/li>\n\n\n\n<li>X-ray crystallography<\/li>\n\n\n\n<li>Molecular biology<\/li>\n\n\n\n<li>Microbiology<\/li>\n\n\n\n<li>Mass spectrometry<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-research-advisor\"><br>Research advisor<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/inrs.ca\/en\/professors\/charles-calmettes\/\">Charles Calmettes<\/a>, professor<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-starting-date\"><br>Starting date<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Winter or Summer 2026<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-study-program\"><br>Study program<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/inrs.ca\/les-etudes\/programmes-d-etudes\/repertoire-des-programmes-d-etudes\/maitrise-en-microbiologie-appliquee-3631\/\">Master\u2019s degree in applied microbiology<\/a> (French description) or <a href=\"https:\/\/inrs.ca\/les-etudes\/programmes-d-etudes\/repertoire-des-programmes-d-etudes\/doctorat-en-biologie-3805\/\">doctorate in biology<\/a> (French description)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-financial-support\"><br>Financial support<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">INRS offers many scholarship programs. Every student-researcher benefits from a grant during their higher education studies.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-profile\"><br>Profile<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The candidate should have a bachelor\u2019s degree or a master\u2019s degree (or equivalent for the Ph.D program) depending on the program of interest. Experience in molecular biology (cloning, mutagenesis), expression\/purification of proteins, protein biochemistry (electrophoresis, enzymology), proteoliposomes, membrane proteins, and structural biology would be an asset. The candidate must master English (oral and writing).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-location\"><br>Location<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/inrs.ca\/en\/research-centres\/armand-frappier-sante-biotechnologie-research-centre\/\">Armand Frappier Sant\u00e9 Biotechnologie Research Centre<br><\/a>531, boulevard des Prairies<br>Laval, Qu\u00e9bec G3X 1S2<br>Canada<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-to-apply\"><br>How to apply<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Interested candidates may submit their application<strong> by email to<\/strong> <a href=\"mailto:charles.calmettes@inrs.ca\">charles.calmettes@inrs.ca<\/a> including the following <strong>documents in PDF<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Motivation letter (maximum 1 page) describing their research interests<\/li>\n\n\n\n<li>Complete CV<\/li>\n\n\n\n<li>The name of three contact information for further reference.<\/li>\n<\/ul>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-questions\">Questions<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Charles Calmettes<br><\/strong>Email: <a href=\"mailto:charles.calmettes@inrs.ca\"><a href=\"mailto:charles.calmettes@inrs.ca\">charles.calmettes@inrs.ca<\/a><\/a><br>Phone: 450-687-5010 extesion 8885<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The ability of pathogenic microorganisms to scavenge essential nutrients within their hosts is a fundamental requirement for pathogenicity. The battle for these nutrients represents an important element of the host \u2013 pathogen interaction; interfering with the nutrient-uptake ability of bacteria represents a promising therapeutic approach.<\/p>\n","protected":false},"featured_media":70038,"parent":19967,"template":"","sectors":[142,679,729],"expertise":[1257,1001,789,785,1256],"project_type":[747],"professor_program":[825,1193],"class_list":["post-20032","project","type-project","status-publish","has-post-thumbnail","hentry","sectors-environnement","sectors-sante-en","sectors-environnement-en","expertise-mass-spectrometry","expertise-microbiology","expertise-molecular-biology","expertise-structural-biology-nanobiology","expertise-x-ray-crystallography","project_type-project-en","professor_program-biology","professor_program-microbiology-and-biotechnology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.1 (Yoast SEO v28.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Structural and functional studies of nickel transporters from pathogenic bacteria | INRS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inrs.ca\/en\/studies\/masters-and-phd-projects\/find-a-masters-or-phd-project\/structural-and-functional-studies-of-nickel-transporters-from-pathogenic-bacteria-bon\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Structural and functional studies of nickel transporters from pathogenic bacteria\" \/>\n<meta property=\"og:description\" content=\"The ability of pathogenic microorganisms to scavenge essential nutrients within their hosts is a fundamental requirement for pathogenicity. 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