Chimie bioorganométallique et catalyse

Centre Armand-Frappier Santé Biotechnologie

531, boulevard des Prairies
Laval (Québec)  H7V 1B7

Voir le centre

Intérêts de recherche

  • Agents thérapeutiques organométalliques multitâches
  • Libération thermosensible ciblée d’agents thérapeutiques
  • Développement de catalyseurs pour l’activation de liens
  • C-H
  • Isolement d’antibiotiques

Son équipe

Mohammad Mehdi Haghdoost Manjili

Chercheur postdoctoral

Anissa Brahami

Doctorat en biologie

Golara Golbaghi

Doctorat en biologie

Hoang-Van Tran

Doctorat en biologie

Robin Vidal

Maîtrise en sciences expérimentales de la santé


33. Chahrour, T.; Castonguay, A.; Oguadinma, P. O., Schaper, F.*; Zargarian, D.* Reactions of a pincer proligand with copper iodide: bridging instead of C-H metalation (under review).

32. Brahami, A.; Létourneau, M.; Chatenet, D.; LaPlante, S.; Déziel, E.*; Castonguay, A.* Discovery of an antimicrobial peptide from the functional metagenomic screening of a hospital biofilm (under review).

​31. Haghdoost, M. M.; Sauvageau, E.; Oguadinma, P.; Tran, H.-V.; Lefrancois, S.; Castonguay, A.* Cu-catalyzed click conjugation of cobalamine to a BODIPY-based fluorophore: a versatile tool to explore the cellular biology of vitamin B12 (under review).

30. Golbaghi, G.; Castonguay, A.*; Zargarian, D.* One-pot synthesis of a PCsp3P-type pincer complex via double C-H palladation of a large chelate ring, Polyhedron 2020, Special Issue in Celebration of the 75th Birthday of John Bercaw (in press).

​29. Golbaghi, G.; Pitard, I.; Lucas, M.; Haghdoost, M. M.; López de los Santos, Y.; Doucet, N.; Patten, S. A.; Sanderson, J. T.; Castonguay, A.* Synthesis and biological assessment of a ruthenium(II) cyclopentadienyl complex in breast cancer cells and on the development of zebrafish embryos, European Journal of Medicinal Chemistry 2020 (in press).

​28. Golbaghi, G.; Castonguay, A.* Rationally designed ruthenium complexes for breast cancer therapy, Molecules 2020, 25, 265 (in press). Special Issue Metal Anticancer Complexes, selected to be featured on the front cover.

​27. Notaro, A.; Gasser, G.*; Castonguay, A.* Note of caution for the aqueous behaviour of metal-based drug candidates, ChemMedChem 2020 (in press).

26. Haghdoost, M. M.; Golbaghi, G.; Guard, J.; Sielanczyk, S.; Patten, S. A.; Castonguay, A.* Synthesis, Characterization and Biological Evaluation of Cationic Organoruthenium(II) Fluorene Complexes: Influence of the Nature of the Counteranion, Dalton Transactions 2019, 48, 13396.

25. Golbaghi, G.; Haghdoost, M. M.; Yancu, D.; López de los Santos, Y.; Doucet, N.; Patten, S. A.; Sanderson, J. T.; Castonguay, A.* Organoruthenium(II) Complexes Bearing an Aromatase Inhibitor: Synthesis, Characterization, in Vitro Biological Activity and in Vivo Toxicity in Zebrafish Embryos, Organometallics 2019, 38, 702.

24. Brahami, A.; Castonguay, A.*; Déziel, E.* Novel « bacteriospray » method facilitates the functional screening of large metagenomic libraries for antimicrobial activity, Methods and Protocols 2019, 2, 4.

23. Shabana, A.; Butler, I. S.; Castonguay, A.; Bertrand, J.-C. J.; Mostafa, S. I.* DNA Interaction and Anticancer Evaluation of New Palladium(II), Platinum(II) and Silver(I) Complexes Based on (Δ)- and (Λ)-1,2–Bis-(1H-benzimidazol-2-yl)-1,2-ethanediol
Enantiomers, Polyhedron 2018, 154, 156.

22. Haghdoost, M.; Guard, J.; Golbaghi, G.; Castonguay, A.* Anticancer Activity and Catalytic Potential of Ruthenium(II) Arene Complexes with N,O donor Ligands, Inorganic Chemistry  2018, 57, 7558.

21. Haghdoost, M.; Golbaghi, G.; Létourneau, M.; Patten, S. A.; Castonguay, A.* Lipophilicity-antiproliferative activity relationship study leads to the preparation of a ruthenium(II) arene complex with considerablein vitrocytotoxicity against cancer cells and a lowerin vivo toxicity in zebrafish embryos than clinically approved cis-platin, European Journal of Medicinal Chemistry 2017, 132, 282.

20. Thamri, A.; Létourneau, M.; Chatenet, D.; Déziel, E.; Castonguay, A.*; Perreault,
J.* Peptide modification results in the formation of a dimer with a 60-fold enhanced antimicrobial activity, PLoS ONE 2017, 12 (3), e0173783.

19. Ishawa, S.; Hudson, R.; Masnadi, M.; Bateman, M.; Castonguay, A.; Braidy, N.; Moores, A.; Li, C.-J.* Cyclopropanation of diazoesters with styrene derivatives catalyzed by magnetically recoverable copper-plated iron nanoparticles, Tetrahedron 2014, 70, 6162.

18. Castonguay, A.; Maysinger, D.* “Click” Reactions: an Emerging Tool for Biology, Frontiers of Nanobiomedical Research 2014, 509 (invited book chapter, edited by Vladimir P. Torchilin).

17. Moquin, A.; Hutter, E.; Choi, A.; Khatchadourian, A.; Castonguay, A.; Winnik, F.;  Maysinger, D.* Caspase-1 Activity in Microglia Stimulated by Pro-Inflammagen Nanocrystals, ACS Nano 2013, 7, 9585.

16. Zargarian, D.*; Castonguay, A.; Spasyuk, D. M. ECE-Type Pincer Complexes of Nickel, Topics in Organometallic Chemistry 2013, 40, 131 (invited book chapter from “Organometallic Pincer Chemistry”, edited by Gerard van Koten and David Milstein).

15. Castonguay, A.; Doucet, C.; Juhas, M.; Maysinger, D.* New Ruthenium-Letrozole Complexes as Anticancer Therapeutics, Journal of Medicinal Chemistry 2012, 55, 8799.

14. Castonguay, A.; Ladd, E.; van de Ven, T. G. M.; Kakkar, A. Dendrimers as Bactericides, New Journal of Chemistry 2012, 36, 199.

13. Castonguay, A.; Wilson, E.; Al-Hajaj, N.; Petitjean, L.; Paoletti, J.; Maysinger, D.; Kakkar, A. Thermosensitive Dendrimer Formulation for Drug Delivery at Physiologically Relevant Temperatures, Chemical Communications 2011, 47, 12146.

12. Castonguay, A.; Kakkar, A. K.* Dendrimer Templated Construction of Silver Nanoparticles, Advances in Colloid and Interface Science 2010, 160, 76.

11. Vieyres, A.; Lam, T.; Gillet, R.; Franc, G.; Castonguay, A.; Kakkar, A. K.* Combined Cu(I)-Catalyzed Alkyne-Azide Cycloaddition and Furan-Maleimide Diels-Alder “Click” Chemistry Approach to Thermoresponsive Dendrimers, Chemical Communications 2010, 46, 1875.

10. Germain, M. E.; Temprado, M.; Castonguay, A.; Kryatova, O. P.; Rybak-Akimova, E. V.; Curley, J. J.; Mendiratta, A.; Tsai, Y.-C.; Cummins, C. C.; Prabhakar, R.; McDonough, J. E.; Hoff, C. D.* Coordination-Mode Control of Bound Nitrile Radical Complex Reactivity: Intercepting End-on Nitrile-Mo(III) Radicals at Low Temperature, Journal of the American Chemical Society 2009, 131, 15412.

9. Castonguay, A.; Spasyuk, D. M.; Madern, N.; Beauchamp, A. L.; Zargarian, D. Regioselective Hydroamination of Acrylonitrile Catalyzed by Cationic Pincer Complexes of Nickel, Organometallics 2009, 28, 2134.

8. Castonguay, A.; Beauchamp, A. L.; Zargarian, D.* New Derivatives of PCP-Type Pincer Complexes of Nickel, Inorganic Chemistry 2009, 48, 3177.

7. Castonguay, A.; Zargarian, D.; Beauchamp, A. L.* Preparation and Reactivities of PCP-Type Pincer Complexes of Nickel. Impact of Different Ligand Skeletons and Phosphine Substituents, Organometallics 2008, 27, 5723.

6. Pandarus, V.; Castonguay, A.; Zargarian, D.* Ni(II) Complexes Featuring Non-Metallated Pincer-Type Ligands, Dalton Transactions 2008, 35, 4756.

5. Castonguay, A.; Beauchamp, A. L.; Zargarian, D.* Trans,trans-Bis[µ-1,5-bis(diisopropylphosphino)pentane-κ2P :P’]bis[dichloronickel(II)], Acta. Cryst. 2007, E62, m196.

4. Sui-Seng, C.; Castonguay, A.; Chen, Y.; Gareau, D.; Groux, L. F.; Zargarian, D.* Catalytic Reactivities of Indenyl-Nickel, Indenyl-Palladium, and PCsp3P-Nickel Complexes, Topics in Catalysis 2006, 37, 81.

3. Castonguay, A.; Sui-Seng, C.; Zargarian, D.; Beauchamp, A. L.* Syntheses and Reactivities of New Pincer Complexes of Nickel, Organometallics 2006, 25, 602.

2. Castonguay A.; Beauchamp, A. L.; Vachon, J.; Zargarian, D.* Chloro[η5-1-(dimethylaminoethyl)indenyl]- (triphenylphosphine)nickel(II) diethyl ether hemisolvate, Acta. Cryst. 2005, E61, m1512

1. Castonguay, A.; Charbonneau, F.; Beauchamp. A. L.; Zargarian, D.* {2,6-Bis[(dimethylamino)methyl]phenyl-κ2N,C1,N’}-chloronickel(II), Acta. Cryst. 2005, E61, m2240.