Chimie bioorganométallique et catalyse

Centre Armand-Frappier Santé Biotechnologie

531, boulevard des Prairies
Laval (Québec)  H7V 1B7

Voir le centre

Intérêts de recherche

  • Agents thérapeutiques organométalliques multitâches
  • Libération thermosensible ciblée d’agents thérapeutiques
  • Développement de catalyseurs pour l’activation de liens
  • C-H
  • Isolement d’antibiotiques

Son équipe

Mohammad Mehdi Haghdoost Manjili

Chercheur postdoctoral

Anissa Brahami

Doctorat en biologie

Golara Golbaghi

Doctorat en biologie

Hoang-Van Tran

Doctorat en biologie

Robin Vidal

Maîtrise en sciences expérimentales de la santé

Activités d’enseignement

Spectrométrie de masse et analyse protéomique (cours et atelier inclus dans le cours MBA6002)

M. Sc. 1re année (Microbiologie appliquée), MBA6002 – Session automne 2014, 2015, 2016, 2017, 2018, 2019
Institut national de la recherche scientifique – Institut Armand-Frappier, Université du Québec

Les Éléments et le Tableau Périodique (chargée de cours)

B. Sc. 1re année (Chimie), CHI2202 – Session hiver 2013
Université du Québec à Montréal

Laboratoire de Chimie Inorganique (co-supervision)

B. Sc. 2e année (Chimie), CHM2202- Session hiver 2012
Université de Montréal

Chimie Inorganique (chargée de cours)

B. Sc. 3e année (Chimie), CHI3202 – Session automne 2011
Université du Québec à Montréal

Supramolecular Chemistry (enseignante invitée, 1 cours)

B. Sc. & Étudiants gradués (Chimie), CHEM582 – Hiver 2011
Université McGill

Advanced Materials (enseignante invitée, 1 cours)

B. Sc. 3e année (Chimie), CHEM334 – Automnes 2010 & 2011
Université McGill

Chimie Organométallique (enseignante invitée, 1 cours)

B. Sc. 3e année (Chimie), CHM3230 Hiver 2007
Université de Montréal


33. Chahrour, T.; Castonguay, A.; Oguadinma, P. O., Schaper, F.*; Zargarian, D.* Reactions of a pincer proligand with copper iodide: bridging instead of C-H metalation (under review).

32. Brahami, A.; Létourneau, M.; Chatenet, D.; LaPlante, S.; Déziel, E.*; Castonguay, A.* Discovery of an antimicrobial peptide from the functional metagenomic screening of a hospital biofilm (under review).

​31. Haghdoost, M. M.; Sauvageau, E.; Oguadinma, P.; Tran, H.-V.; Lefrancois, S.; Castonguay, A.* Cu-catalyzed click conjugation of cobalamine to a BODIPY-based fluorophore: a versatile tool to explore the cellular biology of vitamin B12 (under review).

30. Golbaghi, G.; Castonguay, A.*; Zargarian, D.* One-pot synthesis of a PCsp3P-type pincer complex via double C-H palladation of a large chelate ring, Polyhedron 2020, Special Issue in Celebration of the 75th Birthday of John Bercaw (in press).

​29. Golbaghi, G.; Pitard, I.; Lucas, M.; Haghdoost, M. M.; López de los Santos, Y.; Doucet, N.; Patten, S. A.; Sanderson, J. T.; Castonguay, A.* Synthesis and biological assessment of a ruthenium(II) cyclopentadienyl complex in breast cancer cells and on the development of zebrafish embryos, European Journal of Medicinal Chemistry 2020 (in press).

​28. Golbaghi, G.; Castonguay, A.* Rationally designed ruthenium complexes for breast cancer therapy, Molecules 2020, 25, 265 (in press). Special Issue Metal Anticancer Complexes, selected to be featured on the front cover.

​27. Notaro, A.; Gasser, G.*; Castonguay, A.* Note of caution for the aqueous behaviour of metal-based drug candidates, ChemMedChem 2020 (in press).

26. Haghdoost, M. M.; Golbaghi, G.; Guard, J.; Sielanczyk, S.; Patten, S. A.; Castonguay, A.* Synthesis, Characterization and Biological Evaluation of Cationic Organoruthenium(II) Fluorene Complexes: Influence of the Nature of the Counteranion, Dalton Transactions 2019, 48, 13396.

25. Golbaghi, G.; Haghdoost, M. M.; Yancu, D.; López de los Santos, Y.; Doucet, N.; Patten, S. A.; Sanderson, J. T.; Castonguay, A.* Organoruthenium(II) Complexes Bearing an Aromatase Inhibitor: Synthesis, Characterization, in Vitro Biological Activity and in Vivo Toxicity in Zebrafish Embryos, Organometallics 2019, 38, 702.

24. Brahami, A.; Castonguay, A.*; Déziel, E.* Novel « bacteriospray » method facilitates the functional screening of large metagenomic libraries for antimicrobial activity, Methods and Protocols 2019, 2, 4.

23. Shabana, A.; Butler, I. S.; Castonguay, A.; Bertrand, J.-C. J.; Mostafa, S. I.* DNA Interaction and Anticancer Evaluation of New Palladium(II), Platinum(II) and Silver(I) Complexes Based on (Δ)- and (Λ)-1,2–Bis-(1H-benzimidazol-2-yl)-1,2-ethanediol
Enantiomers, Polyhedron 2018, 154, 156.

22. Haghdoost, M.; Guard, J.; Golbaghi, G.; Castonguay, A.* Anticancer Activity and Catalytic Potential of Ruthenium(II) Arene Complexes with N,O donor Ligands, Inorganic Chemistry  2018, 57, 7558.

21. Haghdoost, M.; Golbaghi, G.; Létourneau, M.; Patten, S. A.; Castonguay, A.* Lipophilicity-antiproliferative activity relationship study leads to the preparation of a ruthenium(II) arene complex with considerablein vitrocytotoxicity against cancer cells and a lowerin vivo toxicity in zebrafish embryos than clinically approved cis-platin, European Journal of Medicinal Chemistry 2017, 132, 282.

20. Thamri, A.; Létourneau, M.; Chatenet, D.; Déziel, E.; Castonguay, A.*; Perreault,
J.* Peptide modification results in the formation of a dimer with a 60-fold enhanced antimicrobial activity, PLoS ONE 2017, 12 (3), e0173783.

19. Ishawa, S.; Hudson, R.; Masnadi, M.; Bateman, M.; Castonguay, A.; Braidy, N.; Moores, A.; Li, C.-J.* Cyclopropanation of diazoesters with styrene derivatives catalyzed by magnetically recoverable copper-plated iron nanoparticles, Tetrahedron 2014, 70, 6162.

18. Castonguay, A.; Maysinger, D.* “Click” Reactions: an Emerging Tool for Biology, Frontiers of Nanobiomedical Research 2014, 509 (invited book chapter, edited by Vladimir P. Torchilin).

17. Moquin, A.; Hutter, E.; Choi, A.; Khatchadourian, A.; Castonguay, A.; Winnik, F.;  Maysinger, D.* Caspase-1 Activity in Microglia Stimulated by Pro-Inflammagen Nanocrystals, ACS Nano 2013, 7, 9585.

16. Zargarian, D.*; Castonguay, A.; Spasyuk, D. M. ECE-Type Pincer Complexes of Nickel, Topics in Organometallic Chemistry 2013, 40, 131 (invited book chapter from “Organometallic Pincer Chemistry”, edited by Gerard van Koten and David Milstein).

15. Castonguay, A.; Doucet, C.; Juhas, M.; Maysinger, D.* New Ruthenium-Letrozole Complexes as Anticancer Therapeutics, Journal of Medicinal Chemistry 2012, 55, 8799.

14. Castonguay, A.; Ladd, E.; van de Ven, T. G. M.; Kakkar, A. Dendrimers as Bactericides, New Journal of Chemistry 2012, 36, 199.

13. Castonguay, A.; Wilson, E.; Al-Hajaj, N.; Petitjean, L.; Paoletti, J.; Maysinger, D.; Kakkar, A. Thermosensitive Dendrimer Formulation for Drug Delivery at Physiologically Relevant Temperatures, Chemical Communications 2011, 47, 12146.

12. Castonguay, A.; Kakkar, A. K.* Dendrimer Templated Construction of Silver Nanoparticles, Advances in Colloid and Interface Science 2010, 160, 76.

11. Vieyres, A.; Lam, T.; Gillet, R.; Franc, G.; Castonguay, A.; Kakkar, A. K.* Combined Cu(I)-Catalyzed Alkyne-Azide Cycloaddition and Furan-Maleimide Diels-Alder “Click” Chemistry Approach to Thermoresponsive Dendrimers, Chemical Communications 2010, 46, 1875.

10. Germain, M. E.; Temprado, M.; Castonguay, A.; Kryatova, O. P.; Rybak-Akimova, E. V.; Curley, J. J.; Mendiratta, A.; Tsai, Y.-C.; Cummins, C. C.; Prabhakar, R.; McDonough, J. E.; Hoff, C. D.* Coordination-Mode Control of Bound Nitrile Radical Complex Reactivity: Intercepting End-on Nitrile-Mo(III) Radicals at Low Temperature, Journal of the American Chemical Society 2009, 131, 15412.

9. Castonguay, A.; Spasyuk, D. M.; Madern, N.; Beauchamp, A. L.; Zargarian, D. Regioselective Hydroamination of Acrylonitrile Catalyzed by Cationic Pincer Complexes of Nickel, Organometallics 2009, 28, 2134.

8. Castonguay, A.; Beauchamp, A. L.; Zargarian, D.* New Derivatives of PCP-Type Pincer Complexes of Nickel, Inorganic Chemistry 2009, 48, 3177.

7. Castonguay, A.; Zargarian, D.; Beauchamp, A. L.* Preparation and Reactivities of PCP-Type Pincer Complexes of Nickel. Impact of Different Ligand Skeletons and Phosphine Substituents, Organometallics 2008, 27, 5723.

6. Pandarus, V.; Castonguay, A.; Zargarian, D.* Ni(II) Complexes Featuring Non-Metallated Pincer-Type Ligands, Dalton Transactions 2008, 35, 4756.

5. Castonguay, A.; Beauchamp, A. L.; Zargarian, D.* Trans,trans-Bis[µ-1,5-bis(diisopropylphosphino)pentane-κ2P :P’]bis[dichloronickel(II)], Acta. Cryst. 2007, E62, m196.

4. Sui-Seng, C.; Castonguay, A.; Chen, Y.; Gareau, D.; Groux, L. F.; Zargarian, D.* Catalytic Reactivities of Indenyl-Nickel, Indenyl-Palladium, and PCsp3P-Nickel Complexes, Topics in Catalysis 2006, 37, 81.

3. Castonguay, A.; Sui-Seng, C.; Zargarian, D.; Beauchamp, A. L.* Syntheses and Reactivities of New Pincer Complexes of Nickel, Organometallics 2006, 25, 602.

2. Castonguay A.; Beauchamp, A. L.; Vachon, J.; Zargarian, D.* Chloro[η5-1-(dimethylaminoethyl)indenyl]- (triphenylphosphine)nickel(II) diethyl ether hemisolvate, Acta. Cryst. 2005, E61, m1512

1. Castonguay, A.; Charbonneau, F.; Beauchamp. A. L.; Zargarian, D.* {2,6-Bis[(dimethylamino)methyl]phenyl-κ2N,C1,N’}-chloronickel(II), Acta. Cryst. 2005, E61, m2240.