Professeur INRS

Projets d'études et stages offerts

Expertises

Toxicologie , Aromatase (CYP19) , Composés naturels , Cytochrome P450 , Perturbateurs endocriniens , Pesticides , Steroïdogénèse

  • Professeur à l’INRS

Téléphone
450 687-5010

Télécopieur
450 686-5501

Courriel
thomas.sanderson@iaf.inrs.ca

Centre Armand-Frappier Santé Biotechnologie

531, boulevard des Prairies
Laval (Québec)  H7V 1B7
CANADA

 

Voir le centre

Intérêts de recherche

Comment les contaminants environnementaux ou les composés naturels peuvent-ils perturber la régulation des enzymes impliquées dans la stéroïdogenèse?

Les recherches du Pr Sanderson se concentrent sur des enzymes impliquées dans la synthèse des œstrogènes et des androgènes, ainsi que le développement des bio-essais cellulaires en co-culture ou en 3-D, comme des modèles plus pertinents pour les études toxicologiques des perturbations endocriniennes. La surexpression de certaines enzymes stéroïogènes est associée à un plus grand risque de certaines pathologies comme des cancers. Le but est d’élucider les voies de signalisation cellulaire impliquées dans la perturbation de la régulation de ces enzymes. Un thème clé du laboratoire est le développement de modèles de co-cultures cellulaires qui réfléchissent la communication physiologique dans l’organisme, plus pertinents comme outils de criblage et des études mécanistiques sur les contaminants, pesticides et médicaments auxquels nous sommes exposés.

 

Futurs étudiants
Le professeur Sanderson recherche des étudiantes et étudiants motivés, ayant l’expérience d’un ou de plusieurs aspects de la toxicologie environnementale, pharmacologie ou biochimie. Les étudiantes et étudiants intéressés sont priés de rejoindre le professeur Thomas Sanderson par courrier électronique à thomas.sanderson@iaf.inrs.ca

 

 

Fonctions et biographie

Le porfesseur J. Thomas Sanderson a complété un baccalauréat (B. Sc., 1989) en chimie du Vrije Universiteit, à Amsterdam, Pays-Bas, et ensuite un doctorat (Ph. D., 1994) en pharmacologie et toxicologie de l’Université de Colombie-Britannique à Vancouver, Canada.

Après un stage postdoctoral au Michigan State University (National Food Safety and Toxicology Centre (1994-1997), il a obtenu un poste de professeur adjoint à l’Université d’Utrecht, Pays-Bas (Institute for Risk Assessment Sciences, 1997-2005) où il a reçu sa permanence en 2003.

Depuis 2005, Thomas Sanderson détient un poste de professeur agrégé au Centre Armand-Frappier Santé Biotechnologie de l’INRS. Sa recherche est concentrée sur l’interaction entre les produits chimiques et les enzymes de la biosynthèse des stéroïdes, liée au développement des cancers hormone-dépendants et aux perturbations du système endocrinien. Ses travaux de recherche sont actuellement financés par le Conseil de recherches en sciences naturelles et en génie du Canada (CRSNG) et se concentrent sur les mécanismes par lesquels les produits chimiques perturbent la synthèse d’androgènes et d’eostrogènes chez les humains et dans les modèles animaux.

Publications

CARON-BEAUDOIN, E., DENISON, M. S. & SANDERSON, J. T. (2015)
Effects of neonicotinoids on promoter-specific expression and activity of aromatase (CYP19) in human adrenocortical carcinoma (H295R) and primary umbilical vein endothelial (HUVEC) cells,
Toxicological Sciences.

 

SANDERSON, J. T. (2015)
Disruptors of Androgen Action and Synthesis.
Endocrine Disruption and Human Health. 76-90.

 

GOLDBERG, A. A., DRAZ, H., MONTES-GRAJALES, D., OLIVERO-VERBEL, J., SAFE, S. H. & SANDERSON, J. T. (2015)
3,3′-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells,
Genes Cancer, 6, 5-6, 265-80.

 

ROBITAILLE, C. N., RIVEST, P. & SANDERSON, J. T. (2015)
Antiandrogenic Mechanisms of Pesticides in Human LNCaP Prostate and H295R Adrenocortical Carcinoma Cells,
Toxicological Sciences, 143, 1, 126-35.

 

GOODSON, W. H., 3RD, LOWE, L., CARPENTER, D. O., GILBERTSON, M., MANAF ALI, A., LOPEZ DE CERAIN SALSAMENDI, A., LASFAR, A., CARNERO, A., AZQUETA, A., AMEDEI, A., CHARLES, A. K., COLLINS, A. R., WARD, A., SALZBERG, A. C., COLACCI, A., OLSEN, A. K., BERG, A., BARCLAY, B. J., ZHOU, B. P., BLANCO-APARICIO, C., BAGLOLE, C. J., DONG, C., MONDELLO, C., HSU, C. W., NAUS, C. C., YEDJOU, C., CURRAN, C. S., LAIRD, D. W., KOCH, D. C., CARLIN, D. J., FELSHER, D. W., ROY, D., BROWN, D. G., RATOVITSKI, E., RYAN, E. P., CORSINI, E., ROJAS, E., MOON, E. Y., LACONI, E., MARONGIU, F., AL-MULLA, F., CHIARADONNA, F., DARROUDI, F., MARTIN, F. L., VAN SCHOOTEN, F. J., GOLDBERG, G. S., WAGEMAKER, G., NANGAMI, G., CALAF, G. M., WILLIAMS, G., WOLF, G. T., KOPPEN, G., BRUNBORG, G., KIM LYERLY, H., KRISHNAN, H., AB HAMID, H., YASAEI, H., SONE, H., KONDOH, H., SALEM, H. K., HSU, H. Y., PARK, H. H., KOTURBASH, I., MIOUSSE, I. R., SCOVASSI, A. I., KLAUNIG, J. E., VONDRACEK, J., RAJU, J., ROMAN, J., WISE, J. P., SR., WHITFIELD, J. R., WOODRICK, J., CHRISTOPHER, J. A., OCHIENG, J., MARTINEZ-LEAL, J. F., WEISZ, J., KRAVCHENKO, J., SUN, J., PRUDHOMME, K. R., NARAYANAN, K. B., COHEN-SOLAL, K. A., MOORWOOD, K., GONZALEZ, L., SOUCEK, L., JIAN, L., D’ABRONZO, L. S., LIN, L. T., LI, L., GULLIVER, L., MCCAWLEY, L. J., MEMEO, L., VERMEULEN, L., LEYNS, L., ZHANG, L., VALVERDE, M., KHATAMI, M., ROMANO, M. F., CHAPELLIER, M., WILLIAMS, M. A., WADE, M., et al. (2015)
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead,
Carcinogenesis, 36 Suppl 1, S254-96.

 

ENGSTROM, W., DARBRE, P., ERIKSSON, S., GULLIVER, L., HULTMAN, T., KARAMOUZIS, M. V., KLAUNIG, J. E., MEHTA, R., MOORWOOD, K., SANDERSON, T., SONE, H., VADGAMA, P., WAGEMAKER, G., WARD, A., SINGH, N., AL-MULLA, F., AL-TEMAIMI, R., AMEDEI, A., COLACCI, A. M., VACCARI, M., MONDELLO, C., SCOVASSI, A. I., RAJU, J., HAMID, R. A., MEMEO, L., FORTE, S., ROY, R., WOODRICK, J., SALEM, H. K., RYAN, E., BROWN, D. G. & BISSON, W. H. (2015)
The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling,
Carcinogenesis, 36 Suppl 1, S38-60.

 

THIBEAULT, A. A., DEROY, K., VAILLANCOURT, C. & SANDERSON, J. T. (2014)
A Unique Co-culture Model for Fundamental and Applied Studies of Human Fetoplacental Steroidogenesis and Interference by Environmental Chemicals,
Environmental Health Perspectives, 122, 4, 371-7.

 

GOLDBERG, A. A., TITORENKO, V. I., BEACH, A., ABDELBAQI, K., SAFE, S. & SANDERSON, J. T. (2014)
Ring-substituted analogs of 3,3′-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells,
Investigational New Drugs, 32, 1, 25-36.

 

SANDERSON, J. T., CLABAULT, H., PATTON, C., LASSALLE-CLAUX, G., JEAN-FRANCOIS, J., PARÉ, A. F., HÉBERT, M. J., SURETTE, M. E. & TOUAIBIA, M. (2013)
Antiproliferative, antiandrogenic and cytotoxic effects of novel caffeic acid derivatives in LNCaP human androgen-dependent prostate cancer cells,
Bioorganic and Medicinal Chemistry, 21, 22, 7182-93.

 

GOLDBERG, A. A., TITORENKO, V. I., BEACH, A. & SANDERSON, J. T. (2013)
Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells,
PeerJ, 1, e122.

 

GASMI, J. & SANDERSON, J. T. (2013)
Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: a mechanistic and 3-D structure-activity study,
Phytomedicine, 20, 8-9, 734-42.

 

RIVEST, P., RENAUD, M. & SANDERSON, J. T. (2011)
Proliferative and androgenic effects of indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic concentrations,
Chemico-Biological Interactions, 189, 3, 177-185.

 

KLEMPAN, T., HUDON-THIBEAULT, A. A., OUFKIR, T., VAILLANCOURT, C. & SANDERSON, J. T. (2011)
Stimulation of serotonergic 5-HT(2A) receptor signaling increases placental aromatase (CYP19) activity and expression in BeWo and JEG-3 human choriocarcinoma cells,
Placenta, 32, 9, 651-656.

 

ABDELBAQI, K., LACK, N., GUNS, E. T., KOTHA, L., SAFE, S. & SANDERSON, J. T. (2011)
Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3′-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells,
Prostate, 71, 13, 1401-12.

 

RIVEST, P., DEVINE, P. J. & SANDERSON, J. T. (2010)
Evaluation of a bioluminescent mouse model expressing aromatase PII-promoter-controlled luciferase as a tool for the study of endocrine disrupting chemicals,
Toxicology and Applied Pharmacology, 249, 1, 33-40.

 

OUFKIR, T., ARSENEAULT, M., SANDERSON, J. T. & VAILLANCOURT, C. (2010)
The 5-HT2A serotonin receptor enhances cell viability, affects cell cycle progression and activates MEK-ERK1/2 and JAK2-STAT3 signalling pathways in human choriocarcinoma cell lines,
Placenta, 31, 5, 439-447.

 

GASMI, J. & SANDERSON, J. T. (2010)
Growth inhibitory, antiandrogenic, and pro-apoptotic effects of punicic acid in LNCaP human prostate cancer cells,
Journal of Agricultural and Food Chemistry, 58, 23, 12149-12156.

 

SANDERSON, J. T. (2009)
Placental and fetal steroidogenesis,
Methods in molecular biology (Clifton, N.J.), 550, 127-136.

 

SINGH, M., ARSENEAULT, M., SANDERSON, T., MURTHY, V. & RAMASSAMY, C. (2008)
Challenges for research on polyphenols from foods in Alzheimer’s disease: Bioavailability, metabolism, and cellular and molecular mechanisms,
Journal of Agricultural and Food Chemistry, 56, 13, 4855-4873.

 

SANDERSON, T., RENAUD, M., SCHOLTEN, D., NIJMEIJER, S., VAN DEN BERG, M., COWELL, S., GUNS, E., NELSON, C., MUTARAPAT, T. & RUCHIRAWAT, S. (2008)
Effects of lactone derivatives on aromatase (CYP19) activity in H295R human adrenocortical and (anti)androgenicity in transfected LNCaP human prostate cancer cells,
European Journal of Pharmacology, 593, 1-3, 92-98.

 

VAN MEEUWEN, J. A., VAN DEN BERG, M., SANDERSON, J. T., VERHOEF, A. & PIERSMA, A. H. (2007)
Estrogenic effects of mixtures of phyto- and synthetic chemicals on uterine growth of prepubertal rats,
Toxicology Letters, 170, 2, 165-76.

 

VAN MEEUWEN, J. A., TER BURG, W., PIERSMA, A. H., VAN DEN BERG, M. & SANDERSON, J. T. (2007)
Mixture effects of estrogenic compounds on proliferation and pS2 expression of MCF-7 human breast cancer cells,
Food and Chemical Toxicology, 45, 11, 2319-2330.

 

HECKER, M., SANDERSON, J. T. & KARBE, L. (2007)
Suppression of aromatase activity in populations of bream (Abramis brama) from the river Elbe, Germany,
Chemosphere, 66, 3, 542-52.

 

SANDERSON, T. (2006)
Pesticides and the disruption of the enzyme aromatase,
Outlooks on Pest Management, 17, 1, 21-23.

 

SANDERSON, J. T. (2006)
The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals,
Toxicological Sciences, 94, 1, 3-21.

 

PETERS, A. K., SANDERSON, J. T., BERGMAN, A. & VAN DEN BERG, M. (2006)
Antagonism of TCDD-induced ethoxyresorufin-O-deethylation activity by polybrominated diphenyl ethers (PBDEs) in primary cynomolgus monkey (Macaca fascicularis) hepatocytes,
Toxicology Letters, 164, 2, 123-132.

 

GRACIA, T., HILSCHEROVA, K., JONES, P. D., NEWSTED, J. L., ZHANG, X., HECKER, M., HIGLEY, E. B., SANDERSON, J. T., YU, R. M. K., WU, R. S. S. & GIESY, J. P. (2006)
The H295R system for evaluation of endocrine-disrupting effects,
Ecotoxicology and Environmental Safety, 65, 3, 293-305.

 

CANTÓN, R. F., SANDERSON, J. T., NIJMEIJER, S., BERGMAN, A., LETCHER, R. J. & VAN DEN BERG, M. (2006)
In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: A novel mechanism of action?,
Toxicology and Applied Pharmacology, 216, 2, 274-281.

 

RANKOUHI, T. R., KOOMEN, B., SANDERSON, J. T., BOSVELD, A. T., SEINEN, W. & VAN DEN BERG, M. (2005)
Induction of ethoxy-resorufin-O-deethylase activity by halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons in primary hepatocytes of the green frog (Rana esculenta),
Environmental Toxicology and Chemistry, 24, 6, 1428-35.

 

LETCHER, R. J., SANDERSON, J. T., BOKKERS, A., GIESY, J. P. & VAN DEN BERG, M. (2005)
Effects of bisphenol A-related diphenylalkanes on vitellogenin production in male carp (Cyprinus carpio) hepatocytes and aromatase (CYP19) activity in human H295R adrenocortical carcinoma cells,
Toxicology and Applied Pharmacology, 209, 2, 95-104.

 

HENEWEER, M., VAN DEN BERG, M., DE GEEST, M. C., DE JONG, P. C., BERGMAN, A. & SANDERSON, J. T. (2005)
Inhibition of aromatase activity by methyl sulfonyl PCB metabolites in primary culture of human mammary fibroblasts,
Toxicology and Applied Pharmacology, 202, 1, 50-8.

 

HENEWEER, M., MUUSSE, M., VAN DEN BERG, M. & SANDERSON, J. T. (2005)
Additive estrogenic effects of mixtures of frequently used UV filters on pS2-gene transcription in MCF-7 cells,
Toxicology and Applied Pharmacology, 208, 2, 170-7.

 

CANTÓN, R. F., SANDERSON, J. T., LETCHER, R. J., BERGMAN, A. & VAN DEN BERG, M. (2005)
Inhibition and induction of aromatase (CYP19) activity by brominated flame retardants in H295R human adrenocortical carcinoma cells,
Toxicological Sciences, 88, 2, 447-455.

 

HENEWEER, M., MUUSSE, M., DINGEMANS, M., DE JONG, P. C., VAN DEN BERG, M. & SANDERSON, J. T. (2005)
Co-culture of primary human mammary fibroblasts and MCF-7 cells as an in vitro breast cancer model,
Toxicological Sciences, 83, 2, 257-63.

 

Van Duursen, M.B., J.T. Sanderson, P.C. De Jong, M. Kraaij, and M. Van Den Berg (2004)
Phytochemicals inhibit catechol-o-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage.
Toxicol. Sci. 81: 316-324 .

 

Van Duursen, M., J.T. Sanderson, M. van der Bruggen, J. van der Linden, and M. van den Berg (2003)
Effects of several dioxin-like compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines.
Toxicol. Appl. Pharmacol. 190: 241-250 .

 

Sanderson, J. T., J. Jordijk, J., M.S. Denison, M.F. Springsteel, M.H. Nantz, and M. Van Den Berg (2004)
Induction and Inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells.
Toxicol. Sci. 82 : 70-79.

 

Sanderson, J.T., J. Boerma, G.W. Lansbergen, and M. van den Berg. (2002)
Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells.
Toxicol. Appl. Pharmacol. 182: 44-54.

 

Sanderson, J.T., L. Slobbe, G.W. Lansbergen, S. Safe, and M. van den Berg (2001)
2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells.
Toxicol. Sci. 6 1: 40-48.

 

Sanderson, J.T., R.J. Letcher, M. Heneweer, J.P. Giesy, and M. van den Berg (2001)
Effects of chloro-s-triazine herbicides and metabolites on aromatase activity in various human cell lines and on vitellogenin production in male carp hepatocytes.
Environ. Health Perspect. 109: 1027-1031.

 

Sanderson, J.T., W. Seinen, J.P. Giesy, and M. van den Berg (2000)
2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity?
Toxicol. Sci. 54: 121-127.

 

Sanderson, J.T., J.M. Aarts, A. Brouwer, K.L. Froese, M.S. Denison, and J.P. Giesy (1996)
Comparison of Ah receptor-mediated luciferase and ethoxyresorufin-O-deethylase induction in H4IIE cells: implications for their use as bioanalytical tools for the detection of polyhalogenated aromatic hydrocarbons.
Toxicol. Appl. Pharmacol. 137: 316-325.

 

Sanderson, J.T., S.W. Kennedy, and J.P. Giesy, J. P. (1998)
In vitro induction of ethoxyresorufin O-deethylase activity and porphyrins by polyhalogenated aromatic hydrocarbons in avian primary hepatocytes.
Environ. Toxicol. Chem. 17: 2006-2018.

 

Sanderson, J.T., D.M. Janz, G.D. Bellward, and J.P. Giesy (1997)
Effects of embryonic and adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic microsomal testosterone hydroxylase activities in great blue herons (Ardea herodias).
Environ. Toxicol. Chem. 16: 1304-1310.

 

Sanderson, J.T., and G.D. Bellward (1995)
Hepatic microsomal ethoxyresorufin O-deethylase-inducing potency in ovo and cytosolic Ah receptor binding affinity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: comparison of four avian species.
Toxicol. Appl. Pharmacol. 132: 131-145.

 

Sanderson, J.T., J.E. Elliott, R.J. Norstrom, P.E. Whitehead, L.E. Hart, K.M. Cheng, and G.D. Bellward (1994)
Monitoring biological effects of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in great blue heron chicks (Ardea herodias) in British Columbia.
J. Toxicol. Environ. Health 41: 435-450.

 

Sanderson, J. T., R.J. Norstrom, J.E. Elliott, L.E. Hart, K.M. Cheng, and G.D. Bellward (1994)
Biological effects of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in double-crested cormorant chicks (Phalacrocorax auritus).
J. Toxicol. Environ. Health 41: 247-265.