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Séminaire sur les métaux toxiques et la santé humaine

Jürgen Gailer, professeur au Département de chimie de l’Université de Calgary, présentera un séminaire portant sur les métaux toxiques et la santé humaine, « Integrative metallomics to establish functional relationships between human exposure to toxic metals and diseases », le 8 novembre 2022 à 11 h, à la salle 2422.

8 novembre 2022

11 h 00

Centre Eau Terre Environnement

490, rue de la Couronne

Québec (Québec)  G1K 9A9

En présence : salle 2422


Résumé :

The chronic low-level exposure of humans to pollutants is associated with numerous adverse health effects and globally causes ~9 million deaths per year. Climate change driven changes to global precipitation patterns contribute to this undesirable situation as many jurisdictions in affected areas are forced to use pollutant-laden wastewater for the irrigation of food crops. Owing to their intrinsic environmental persistence, toxic metal species (Hg2+, CH3Hg+, Cd2+) represent a unique pollutant class, but gaining insight into the corresponding exposure-response relationships represents a major public health problem in the post-genomic era. While epidemiological studies have been helpful to establish exposure-response associations, enforcing more stringent regulations on the emission of pollutant metals into the environment will ultimately require causal links between exposure and disease. Since the bloodstream represents a biological fluid which separates the environment from our organs, biomolecular processes which unfold therein fundamentally determine if and how much of an ingested toxic metal species will reach toxicological target organs. Gaining insight into these processes, however, is hampered by the biological complexity of the bloodstream, but can be overcome by applying so-called metallomics tools. An overview of recent results will be presented which illustrate that bioinorganic chemistry processes that unfold in the bloodstream-organ system are fundamentally involved in establishing root causes for human diseases of unknown origin that are linked to inorganic environmental pollutant metal.

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