Areas of expertise
Immunology, inflammation and nanotoxicology , Inflammation and physiology of granulocytes
- Professor
Armand-Frappier Santé Biotechnologie Research Centre
531 blvd des Prairies
Laval, Quebec H7V 1B7
CANADA
Research interests
Pr Girard is director of the research in inflammation and physiology of granulocytes laboratory. His works focus on the molecular and cellular mechanisms involved in activated neutrophils in response to diverse agents including cytokines, drugs, and several xenobiotics, aimed at better understanding and regulating inflammation. The identification of new molecules regulating several functions of neutrophils, key player cells in inflammation, could lead to the development of new therapeutic strategies for treating inflammatory diseases or related disorders. His research covers both in vitro and in vivo aspects of inflammation.
Dr. Denis Girard received both his B.Sc. and M.Sc. in biology from the Université du Québec a Montréal. His B.Sc. speciality was in experimental biology while his M.Sc. was in immunotoxicology. He then obtained a Ph.D. in microbiology and immunology from the Université de Montréal while holding a FRSQ predoctoral award. He was working on the characterization of human autoantibodies such as anti-cytoskeletal antibodies. He then moved to the Centre Hospitalier (CHUL) de l’Université Laval for his post-doctoral training in the Department of Rheumatology and Immunology for about 3 years. He was awarded by the MRC/Arthritis Society joint program.
Dr. Girard was recognized for his work on interactions between some cytokines/receptors and the human neutrophil cells known to be implicated in inflammation. Particularly, he was the very first to find that interleukin-15 is a potent human neutrophil agonist. He recently obtained from the FRSQ a scholarship award and a setting up grant for young investigator.
Publications
Vanharen M, Girard D.
Activation of Human Eosinophils with Nanoparticles: a New Area of Research.
Inflammation 2019 Aug 2. doi: 10.1007/s10753-019-01064-4. [Epub ahead of print]
Vallières F, Durocher I, Girard D.
Biological activities of interleukin (IL)-21 in human monocytes and macrophages.
Cell Immunol. 337: 62-70, 2019.
Pelletier M, Simard JC, Girard D, Tessier PA.
Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9.
Blood Adv. 2:1170-1171, 2018.
Chhay P, Murphy-Marion M, Samson Y, Girard D.
Activation of human eosinophils with palladium nanoparticles (Pd NPs): importance of the actin cytoskeleton in Pd NPs-induced cellular adhesion.
Environ Toxicol Pharmacol 57: 95-103, 2018.
Berger E, Breznan D, Stals S, Jasinghe VJ, Goncalves DM, Girard D, Faucher S, Vincent R, Thierry AR, Lavigne.
Cytotoxicity assessment, inflammatory properties, and cellular uptake of Neutraplex lipid-based nanoparticles in THP-1 monocyte-derived macrophages.
Nanobiomedicine 4: 1-14, 2017.
Murphy-Marion M, Girard D.
Activation des éosinophiles humains par des nanoparticules
IRSST, Prévention des risques chimiques et biologiques, Études et recherches, Rapport scientifique R-990, pp 38, 2017
Murphy-Marion M, Girard D.
Titanium dioxide nanoparticles induce human eosinophil adhesion onto endothelial EA.hy926 cells via activation of phosphoinositide 3-kinase/Akt cell signalling pathway.
Immunobiology 223: 162-170, 2018.
Ricci-Azevedo R, Gonçales RA, Roque-Barreira MC, Girard D.
Human neutrophils are targets to paracoccin, a lectin expressed by Paracoccidioides brasiliensis.
Inflamm Res. 67: 31-41, 2018.
Durocher I, Noël C, Lavastre V, Girard D.
Evaluation of the in vitro and in vivo proinflammatory activities of gold (+) and gold (-) nanoparticles.
Inflamm Res. 66: 981-992, 2017.
Girard D.
Imunomodulatory Activities of Silver nanoparticles (Ag NPs) in Human Neutrophils in Silver Nanoparticles for Antibacterial Devices: Biocompatibility and Toxicity, Chapter 9, Huiliang Cao Eds, CRC Press, 2017.
Vallières F, Girard D.
Mechanism involved in interleukin (IL)-21-induced phagocytosis in human monocytes and macrophages.
Clin Exp Immunol. 187: 294-303, 2017.
imard JC, Durocher I, Girard D.
Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells.
Apoptosis. 21: 1279-1290, 2016.
Silva LR, Girard
Human eosinophils are direct targets to nanoparticles: Zinc oxide nanoparticles (ZnO) delay apoptosis and increase the production of the pro-inflammatory cytokines IL-1β and IL-8.
Toxicol Lett. 259:11-20, 2016.
Durocher I, Girard D.
In vivo proinflammatory activity of generations 0-3 (G0-G3) polyamidoamine (PAMAM) nanoparticles.
Inflamm Res Sep;65(9):745-55, 2016.
Valières F, Simard J-C, Noël C, Murphy-Marion M, Lavastre V, Girard D.
Activation of human AML14.3D10 eosinophils by nanoparticles: Modulatory activity on apoptosis and cytokine production.
J Immunotox Jul 12:1-10, 2016.
Vallières F, Simard JC, Stafford-Richard T, Girard D.
Prolonged cultures of unstimulated human neutrophils lead to the apparition and persistence of rest-in-plate structures (RIPs) recognized by professional phagocytes in vitro and in vivo.
Int J Biochem Cell Biol 69: 62-69, 2015.
Noël C, Simard JC, Girard D.
Gold nanoparticles induce apoptosis, endoplasmic reticulum stress events and cleavage of cytoskeletal proteins in human neutrophils.
Toxicol in vitro 2015 Nov 7. pii: S0887-2333(15)30005-9.
Poirier M, Simard JC, Girard D.
Silver nanoparticles of 70 nm and 20 nm affect differently the biology of human neutrophils.
J Immunotox 2015 Nov 30:1-11. [Epub ahead of print]
Lavastre V, Gonçalves DM, Girard D.
Procédures et évaluation du potentiel pro-inflammatoire des nanoparticules
IRSST, Prévention des risques chimiques et biologiques, Études et recherches, Rapport scientifique R-886, pp. 32, 2015.
Babin K, Goncalves DM, Girard D.
Nanoparticles enhance the ability of human neutrophils to exert phagocytosis by a Syk-dependent mechanism.
BBA – General Subjects 1850:2276-2282, 2015.
Liz R, Simard JC, Araújo Leonardi LB, Girard D.
Silver nanoparticles rapidly induce atypical human neutrophil cell death by a process involving inflammatory caspases and reactive oxygen species and induce neutrophil extracellular traps release upon cell adhesion.
Int Immunopharmacol 28: 616-625,2015.
Guedj AS, Kell AJ, Barnes M, Stals S, Gonçalves DM, Girard D, Lavigne C.
Preparation, characterization, and safety evaluation of poly(lactide-co-glycolide) nanoparticles for protein delivery into macrophages.
Int J. Nanomedicine 10: 5965-5979, 2015.
Girard D.
Focussing on neutrophils for evaluating in vitro and in vivo inflammatory activities of nanoparticles in “Nanomaterials – Toxicity and Risk Assessment“, ISBN 978-953-51-2143-5, chapter 3, 39-67, 2015.
http://dx.doi.org/10.5772/60703
Simard JC, Vallières F, de Liz R, Lavastre V, Girard D.
Silver Nanoparticles Induce Degradation of the Endoplasmic Reticulum Stress Sensor Activating Transcription Factor-6 Leading to Activation of the NLRP-3 Inflammasome
J. Biol. Chem. 290: 5926-39, 2015.
Antoine F, Girard D.
Curcumin increases gelatinase activity in human neutrophils by a p38 mitogen-activated protein kinase (MAPK)-independent mechanism.
J. Immunotox. 12: 188-193, 2015.
Simard JC, Noël C, Tessier PA, Girard D.
Human S100A9 potentiates IL-8 production in response to GM-CSF or fMLP via activation of a different set of transcription factors in neutrophils.
FEBS Letters 588: 2141-2146, 2014.
Antoine F, Girard D.
Curcumin and inflammation: the role of neutrophils.
Curcumin: Synthesis, Emerging Role in Pain Management and Health Implications, Nova Science Publishers, 2014 (in press)
Girard D.
Using the air pouch model for assessing in vivo inflammatory activity of nanoparticles.
Int J. Nanomedicine 9: 1105-1109, 2014.
Goncalves DM, Girard D.
Zinc oxide nanoparticles delay human neutrophil apoptosis by a de novo protein synthesis-dependent and reactive oxygen species-independent mechanism.
Toxicol in vitro. 28(5): 926-931, 2014.
Poirier M, Simard JC, Antoine F, Girard D.
Interaction between silver nanoparticles of 20 nm (AgNP20) and human neutrophils: induction of apoptosis and inhibition of de novo protein synthesis by AgNP20 aggregates.
J. Appl. Toxicol. 34: 404-412, 2014.
Gonçalves DM, Girard D.
Evidence that polyhydroxylated C60 Fullerenes (Fullerenols) amplify the effect of lipopolysaccharides to induce a rapid leukocyte infiltration in vivo.
Chem. Res. Toxicol. 26: 1884-1892, 2013.
Antoine F, Simard JC, Girard D.
Curcumin inhibits agent-induced human neutrophil functions in vitro and lipopolysaccharide-induced neutrophilic infiltration in vivo.
Int. Immunopharm. 17: 1101-1107, 2013.
Simard JC, Cesaro A, Chapeton-Montes J, Tardif M, Antoine F, Girard D, Tessier PA.
S100A8 and S100A9 Induce Cytokine Expression and Regulate the NLRP3 Inflammasome via ROS-Dependent Activation of NF-κB.
PLOS One; 2013 Aug 19;8(8):e72138. doi: 10.1371/journal.pone.0072138. (In press). 2013.
Antoine F, Girard D.
Mechanisms involved in curcumin-induced human neutrophil apoptosis: Evidence that curcumin activates the endoplasmic reticulum stress-induced cell apoptosis pathway.
SAGE Open Medicine; 1: 2050312113488104, 1-7, 2013.
Babin K, Antoine F, Goncalves DM, Girard D.
TiO2, CeO2 and ZnO nanoparticles and modulation of the degranulation process in human neutrophils.
Toxicol Letters 221: 57-63, 2013.
Vallières F, Girard D.
IL-21 Enhances Phagocytosis in Mononuclear Phagocyte Cells: Identification of Spleen Tyrosine Kinase as a Novel Molecular Target of IL-21.
Journal of Immunology 190: 2904-2912, 2013.
Simon MM, Simard JC, Girard D.r
Viscum album agglutinin-I (VAA-I) increases cell surface expression of cytoskeletal proteins in apoptotic human neutrophils: Moesin and ezrin are two novel targets of VAA-I.
Human & Experimental Toxicology 32:1097-1106, 2013.
de Liz R, Horst H, Pizzolatti MG, Fröde TS, Girard D.
Activation of Human Neutrophils by the Anti-Inflammatory Mediator Esenbeckia leiocarpa Leads to Atypical Apoptosis.
Mediators Inflamm 2012:198382. Epub 2012 May 8.
de Liz R, Horst H, Pizzolatti MG, Fröde TS, Girard D.
Activation of human neutrophils by Esenbeckia leiocarpa: comparison between the crude hydroalcoholic extract (CHE) and an alkaloid (Alk) fraction.
J Inflamm (Lond) 9:19, 2012.
Goncalves DM, de Liz R, Girard D.
The inflammatory process in response to nanoparticles.
ScientificWorldJournal 11: 2441-2, 2011.
LIZ R, PEREIRA DF, HORST H, DALMARCO EM, DALMARCO JB, SIMIONATTO EL, PIZZOLATTI MG, GIRARD D, FRODE TS.
Protected effect of Esenbeckia leiocarpa upon the inflammatory response induced by carrageenan in a murine air pouch model
International Immunopharmacology 11: 1991-1999, 2011.
GONCALVES DM, LIZ R, GIRARD D.
Activation of neutrophils by nanoparticles
TheScientificWorld Journal 11: 1877-1885, 2011.
SIMARD JC, SIMON MM, TESSIER PA, GIRARD,D.
Damage-Associated Molecular Pattern S100A9 Increases Bactericidal Activity of Human Neutrophils by Enhancing Phagocytosis
Journal of Immunology 186: 3622-3631, 2011.
GONCALVES DM, GIRARD D.
Titanium dioxide (TiO2) nanoparticles induce neutrophil influx and local production of several pro-inflammatory mediators in vivo
International Immunopharmacology 11: 1109-1115, 2011.
BINET F, CHIASSON S, GIRARD D.
Interaction between arsenic trioxide (ATO) and human neutrophils
Human & Experimental Toxicology 30: 416-424, 2011.
SIMARD JC, GIRARD D, TESSIER PA.
Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism.
Journal of Leukocyte Biology 87, 5, 905-14, 2010
GONCALVES DM, CHIASSON S, GIRARD D.
Activation of human neutrophils by titanium dioxide (TiO2) nanoparticles.
Toxicology In Vitro 24: 1002-1008, 2010.
GABRIEL C, MCMASTER WR, GIRARD D, DESCOTEAUX A.
Leishmania donovani Promastigotes Evade the Antimicrobial Activity of Neutrophil Extracellular Traps.
Journal of Immunology 185: 4319-4327, 2010.
BINET F, CHIASSON S. GIRARD D.
Evidence that endoplasmic reticulum (ER) stress and caspase-4 activation occur in human neutrophils.
Biochemical and Biophysical Research Communications 391: 18-23, 2010.
BINET F, CHIASSON S, GIRARD D.
Arsenic trioxide induces endoplasmic reticulum stress-related events in neutrophils.
International Immunopharmacology 10, 4, 508-512, 2010.
ANTOINE F, ENNACIRI J, GIRARD D.
Syk is a novel target of arsenic trioxide (ATO) and is involved in the toxic effect of ATO in human neutrophils.
Toxicology In Vitro , 24, 3, 936-941, 2010.
RATTHÉ C, ENNACIRI J, GONCALVES DM, CHIASSON S, GIRARD D.
Interleukin (IL)-4 induces leukocyte infiltration in vivo by an indirect mechanism.
Mediators of Inflammation , 2009, 193970
ENNACIRI J, GIRARD D.
Immune system: maturation of myeloid cells.
Methods in molecular biology , 550, 195-203, 2009.
ENNACIRI J, GIRARD D.
IL-4R{alpha}, a New Member that Associates with Syk Kinase: Implication in IL-4-Induced Human Neutrophil Functions.
Journal of Immunology , 183: 5261-5269, 2009.
BINET F, GIRARD D.
The anticancer drug arsenic trioxide is an important neutrophil agonist.
Austral-Asian journal of cancer, 8: 169-172, 2009.
BINET F, ANTOINE F, GIRARD D.
Interaction between arsenic trioxide and human primary cells: emphasis on human cells of myeloid origin.
Inflammation and Allergy Drug Targets, 8: 21-27, 2009.
BEAULIEU J, GIRARD D, DUPONT C, LEMIEUX P.
Inhibition of neutrophil infiltration by a malleable protein matrix of lactic acid bacteria-fermented whey proteins in vivo.
Inflammation Research, 58: 133-138, 2009.
RATTHÉ C, GIRARD D.
Investigation of the interleukin (IL)-4/IL-4 receptor system in promyelocytic leukaemia PLB-985 cells during differentiation toward neutrophil-like phenotype: Mechanism involved in IL-4-induced SOCS3 protein expression.
British Journal of Haematology , 140: 59-70, 2008.
BINET F, GIRARD D.
Novel human neutrophil agonistic properties of arsenic trioxide: involvement of p38 mitogen-activated protein kinase and/or c-jun NH2-terminal MAPK but not extracellular signal-regulated kinases-1/2.
Journal of Leukocyte Biology, 84, 6, 1613-1622, 2008.
BINET F, CHIASSON S, GIRARD D.
Arsenic trioxide induces de novo protein synthesis of annexin-1 in neutrophils: Association with a heat shock-like response and not apoptosis.
British Journal of Haematology, 140: 454-463, 2008.
RATTHÉ, C., PELLETIER, M., CHIASSON, S. & GIRARD, D.
Molecular mechanisms involved in interleukin-4-induced human neutrophils: Expression and regulation of suppressor of cytokine signaling
Journal of Leukocyte Biology, 81: 1287-1296, 2007.
PELLETIER, M. & GIRARD, D.
Biological functions of interleukin-21 and its role in inflammation
TheScientificWorldJournal, 7: 1715-1735, 2007.
MOISAN, E., CHIASSON, S. & GIRARD, D.
The intriguing normal acute inflammatory response in mice lacking vimentin
Clinical and Experimental Immunology, 150: 158-168, 2007.
LAVASTRE, V., BINET, F., MOISAN, E., CHIASSON, S. & GIRARD, D.
Viscum album agglutinin-I induces degradation of cytoskeletal proteins in leukaemia PLB-985 cells differentiated toward neutrophils: Cleavage of non-muscle myosin heavy chain-IIA by caspases
British Journal of Haematology, 138: 545-554, 2007.
GIRARD, D. & TESSIER, P. A.
Inflammation and neutrophils: A short introduction .
Phenotypic and functional changes of neutrophils activated by recently identified modulators. 1-8, 2007.
GIRARD, D. & PELLETIER, M.
In vitro and in vivo roles of CD132 (γc)-dependent cytokines in neutrophils and inflammation .
Phenotypic and functional changes of neutrophils activated by recently identified modulators. 27-50, 2007.
GIRARD, D.
Cytoskeleton breakdown in spontaneous and anti-cancer drug-induced neutrophil apoptosis
Phenotypic and functional changes of neutrophils activated by recently identified modulators. 121-134, 2007.
BRKOVIC, A., PELLETIER, M., GIRARD, D. & SIROIS, M. G.
Angiopoietin chemotactic activities on neutrophils are regulated by PI-3K activation
Journal of Leukocyte Biology, 81: 1093-1101, 2007.
PELLETIER, M. & GIRARD, D.
Differential effects of IL-15 and IL-21 in myeloid (CD11b+) and lymphoid (CD11b-) bone marrow cells
Journal of Immunology, 177: 100-108, 2006.
MOISAN, E. & GIRARD, D.
Cell surface expression of intermediate filament proteins vimentin and lamin B1 in human neutrophil spontaneous apoptosis
Journal of Leukocyte Biology, 79: 489-498, 2006.
BINET, F., CAVALLI, H., MOISAN, E. & GIRARD, D.
Arsenic trioxide (AT) is a novel human neutrophil pro-apoptotic agent: Effects of catalase on AT-induced apoptosis, degradation of cytoskeletal proteins and de novo protein synthesis
British Journal of Haematology, 132: 349-358, 2006.
PELLETIER, M. & GIRARD, D.
Interleukin-15 increases neutrophil adhesion onto human respiratory epithelial A549 cells and attracts neutrophils in vivo
Clinical and Experimental Immunology, 141: 315-325, 2005.
LAVASTRE, V., CHIASSON, S., CAVALLI, H. & GIRARD, D.
Viscum album agglutinin-I induces apoptosis and degradation of cytoskeletal proteins via caspases in human leukaemia eosinophil AML14.3D10 cells: Differences with purified human eosinophils
British Journal of Haematology, 130: 527-535, 2005.
LAVASTRE, V., CHIASSON, S., CAVALLI, H. & GIRARD, D. Viscum album agglutinin-I (VAA-I) induces apoptosis and degradation of cytoskeletal proteins in human leukemia PLB-985 and X-CGD cells via caspases: Lamin B-1 is a novel target of VAA-I
Leukemia Research, 29: 1443-1453, 2005.
RATTHÉ, C. & GIRARD, D. Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain.
Journal of Leukocyte Biology, 76: 162-168, 2004.
PELLETIER, M., BOUCHARD, A. & GIRARD, D. In vivo and in vitro roles of IL-21 in inflammation
Journal of Immunology, 173: 7521-7530, 2004.
LAVASTRE, V., CAVALLI, H., RATTHÉ, C. & GIRARD, D. Anti-inflammatory effect of Viscum album agglutinin-I (VAA-I): Induction of apoptosis in activated neutrophils and inhibition of lipopolysaccharide-induced neutrophilic inflammation in vivo
Clinical and Experimental Immunology, 137: 272-278, 2004.
BOUCHARD, A., RATTHÉ, C. & GIRARD, D.
Interleukin-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors: Role of Mcl-1 and decreased activity of caspase-3 and caspase-8
Journal of Leukocyte Biology, 75: 893-900, 2004.
MOISAN, E., KOUASSI, E. & GIRARD, D.
Mechanisms involved in methylmercuri chloride (MeHgCl)-induced suppression of human neutrophil apoptosis
Human and Experimental Toxicology, 22: 629-637, 2003.
GIRARD, D.
Phenotypic and Functional Change of Neutrophils Activated by Cytokines Utilizing the Common Cytokine Receptor Gamma Chain
Chemical Immunology and Allergy, 83, 64-80, 2003.
GIRARD, D.
Activation of human polymorphonuclear neutrophils by environmental contaminants
Reviews on Environmental Health, 18: 75-89, 2003.
RATTHÉ, C., PELLETIER, M., ROBERGE, C. J. & GIRARD, D.
Activation of human neutrophils by the pollutant sodium sulfite: Effect on cytokine production, chemotaxis, and cell surface expression of cell adhesion molecules
Clinical Immunology, 105: 169-175, 2002.
PELLETIER, M., RATTHÉ, C. & GIRARD, D.
Mechanisms involved in interleukin-15-induced suppression of human neutrophil apoptosis: Role of the anti-apoptotic Mcl-1 protein and several kinases including Janus kinase-2, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2
FEBS Letters, 532: 164-170, 2002.
PELLETIER, M., LAVASTRE, V. & GIRARD, D.
Activation of human epithelial lung A549 cells by the pollutant sodium sulfite: Enhancement of neutrophil adhesion
Toxicological Sciences, 69: 210-216, 2002.
PELLETIER, M. & GIRARD, D.
Dieldrin induces human neutrophil superoxide production via protein kinases C and tyrosine kinases
Human and Experimental Toxicology, 21: 415-420, 2002.
MOISAN, E., ARBOUR, S., NGUYEN, N., HÉBERT, M. J., GIRARD, D., BERNIER, J., FOURNIER, M. & KOUASSI, E.
Prolongation of human neutrophil survival by low-level mercury via inhibition of spontaneous apoptosis
Journal of Toxicology and Environmental Health Part A , 65: 183-203, 2002.
LAVASTRE, V., ROBERGE, C. J., PELLETIER, M., GAUTHIER, M. & GIRARD, D.
Toxaphene, but not beryllium, induces human neutrophil chemotaxis and apoptosis via reactive oxygen species (ROS): Involvement of caspases and ROS in the degradation of cytoskeletal proteins
Clinical Immunology, 104: 40-48, 2002.
LAVASTRE, V., PELLETIER, M., SALLER, R., HOSTANSKA, K. & GIRARD, D.
Mechanisms involved in spontaneous and Viscum album agglutinin-I-induced human neutrophil apoptosis: Viscum album agglutinin-I accelerates the loss of antiapoptotic Mcl-1 expression and the degradation of cytoskeletal paxillin and vimentin proteins via caspases
Journal of Immunology, 168: 1419-1427, 2002.
LAVASTRE, V. & GIRARD, D.
Tributyltin induces human neutrophil apoptosis and selective degradation of cytoskeletal proteins by caspases
Journal of toxicology and environmental health. Part A , 65: 1013-1024, 2002.
PELLETIER, M., ROBERGE, C. J., GAUTHIER, M., VANDAL, K., TESSIER, P. A. & GIRARD, D.
Activation of human neutrophils in vitro and dieldrin-induced neutrophilic inflammation in vivo
Journal of Leukocyte Biology, 70: 367-373, 2001.
PELLETIER, M., LAVASTRE, V., SAVOIE, A., RATTHÉ, C., SALLER, R., HOSTANSKA, K. & GIRARD, D.
Modulation of interleukin-15-induced human neutrophil responses by the plant lectin Viscum album agglutinin-I
Clinical Immunology, 101: 229-236, 2001.
GAUTHIER, M., ROBERGE, C. J., PELLETIER, M., TESSIER, P. A. & GIRARD, D.
Activation of human neutrophils by technical toxaphene
Clinical Immunology, 98: 46-53, 2001.
GAUTHIER, M. & GIRARD, D.
Activation of human neutrophils by chlordane: induction of superoxide production and phagocytosis but not chemotaxis or apoptosis
Human and Experimental Toxicology, 20: 229-235, 2001.
SAVOIE, A., LAVASTRE, V., PELLETIER, M., HAJTO, T., HOSTANSKA, K. & GIRARD, D.
Activation of human neutrophils by the plant lectin Viscum album agglutinin-I: Modulation of de novo protein synthesis and evidence that caspases are involved in induction of apoptosis
Journal of Leukocyte Biology, 68: 845-853, 2000.
PELLETIER, M., SAVOIE, A. & GIRARD, D.
Activation of human neutrophils by the air pollutant sodium sulfite (NA2SO3): Comparison with immature promyelocytic HL-60 and DMSO-differentiated HL-60 cells reveals that NA2SO3 is a neutrophil but not a HL-60 cell agonist
Clinical Immunology, 96: 131-139, 2000.
LABBE, P., PELLETIER, M., OMARA, F. O. & GIRARD, D.
Functional Responses of Human Neutrophils to Sodium Sulfite (Na2so3) in Vitro
Human & Experimental Toxicology, 17: 600-605, 1998.
GIRARD, D., BOIANI, N. & BEAULIEU, A. D.
Human Neutrophils Express the Interleukin-15 Receptor Alpha Chain (Il-15r Alpha) but Not the Il-9r Alpha Component
Clinical Immunology and Immunopathology, 88: 232-240, 1998.
GIRARD, D., PAQUIN, R. & BEAULIEU, A. D.
Responsiveness of human neutrophils to interleukin-4: induction of cytoskeletal rearrangements, de novo protein synthesis and delay of apoptosis
Biochemical Journal, 325: 147-153, 1997.
GIRARD, D. & BEAULIEU, A. D.
Absence of the IL-7 receptor component CDw127 indicates that gamma(c) expression alone is insufficient for IL-7 to modulate human neutrophil responses
Clinical Immunology and Immunopathology, 83: 264-71, 1997.
GIRARD, D. & SENÉCAL, J. L.
A novel anti-microfilament antibody, anti-135 kD, is associated with Raynaud’s disease, undifferentiated connective tissue disease and systemic autoimmune diseases
Autoimmunity, 24: 167-77, 1996.
GIRARD, D., PAQUIN, R., NACCACHE, P. H. & BEAULIEU, A. D.
Effects of interleukin-13 on human neutrophil functions
Journal of Leukocyte Biology, 59: 412-419, 1996.
GIRARD, D., PAQUET, M. E., PAQUIN, R. & BEAULIEU, A. D.
Differential effects of interleukin-15 (IL-15) and IL-2 on human neutrophils: modulation of phagocytosis, cytoskeleton rearrangement, gene expression, and apoptosis by IL-15
Blood, 88: 3176-3184, 1996.
GIRARD, D., GOSSELIN, J., HEITZ, D., PAQUIN, R. & BEAULIEU, A. D.
Effects of interleukin-2 on gene expression in human neutrophils
Blood, 86: 1170-1176, 1995.
BERNIER, J., GIRARD, D., KRZYSTYNIAK, K., CHEVALIER, G., TROTTIER, B., NADEAU, D., ROLA-PLESZCZYNSKI, M. & FOURNIER, M.
Immunotoxicity of aminocarb. III. Exposure route-dependent immunomodulation by aminocarb in mice
Toxicology, 99: 135-146, 1995.