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Institut national de la recherche scientifique
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Jean-François Naud

Areas of expertise

Proteins biochemistry , Doping control , peptide hormones

Phone
450-687-8801

Email
jean-francois.naud@inrs.ca

Armand-Frappier Santé Biotechnologie Research Centre

531 des Prairies Blvd
Laval, Quebec H7V 1B7
CANADA

See the research centre

Employed at the doping control laboratory since 2009, Professor Naud was initially responsible for analyses aimed at detecting abuse of erythropoiesis-stimulating agents, recombinant growth hormone, homologous transfusions, synthetic hemoglobins, and the measurement of blood parameters necessary for the athlete’s biological passport during the 2010 Winter Olympic and Paralympic Games in Vancouver. These responsibilities remain an integral part of his work. In 2012, the laboratory became an Athlete Passport Management Unit (APMU). Among the anti-doping organizations working with the laboratory are the Canadian Centre for Ethics in Sport, the International Tennis Federation, the International Triathlon Union, the International Canoe Federation, and the anti-doping commissions of Jamaica and Guatemala.

Publications

Guest speaker
  1. Evaluation of endocrine passports and practical recommendations, 2024, WADA 1st APMU Workshop, Cologne, Germany
  2. Validation of a new method for the athlete biological passport, 2022, WADA Athlete Biological Passport Symposium, New Delhi, India.
  3. Providing target testing recommendations, 2018, WADA Athlete Biological Passport Symposium, Shaping the Present and Future of the ABP, Rome, Italy.

Conferences

  1. Detection of activin receptor type IIA and II-B-Fc fusion proteins by automated capillary immunoassay, 2022, Manfred Donike Workshop, Cologne, Germany
  2. Development of a capillary-electrophoresis method for the detection of recombinant erythropoietins, 2018, Manfred Donike Workshop, Cologne, Germany
  3. Statistical analysis of the hGH ratios obtained from routine testing of athletes’ samples, 2014, Manfred Donike Workshop, Cologne, Germany
Conferences (laboratory members)
  1. Soucy, Myriam, Morneau, Éric, Ricard, Simon, Daoust, Benoit, Sansoucy, Maxime, Naud, Jean-François, In vitro SR9011 metabolism study using tandem mass spectrometry, 2024, Manfred Donike Workshop, Cologne, Germany
  2. Barber, Andrew, Naud, Jean-François, GC-C-IRMS confirmation of Boldenone across sample matrices, 2024, Manfred Donike Workshop, Cologne, Germany

Peer-reviewed publications

  1. Reichel, Christian, Reihlen, Phillip, Naud, Jean-François, Martin, Laurent, Miller, Geoff, Dehnes, Yvette, Inter-Laboratory validation of biotinylated clone AE7A5-antibody for detection by single blotting of urine and blood samples, Drug Test Anal., 2023, in preparation.
  2. Sansoucy, Maxime, Naud, Jean-François. Using Proteins As Markers for Anabolic Steroid Abuse: A New Perspective in Doping Control? Chem Res Toxicol., 2023, Aug 21;36(8):1168-1173.
  3. Desharnais, Philippe, Naud, Jean-François. Detection of activin receptor type IIA and IIB-Fc fusion proteins by automated capillary immunoassay. Drug Test Anal., 2022, Nov;14(11-12):1938-1951.
  4. Naud, Jean-François, Giraud, Sylvain, Robinson, Neil, Desharnais, Philippe, Ericsson, Magnus, Saugy, Martial, Kuuranne, Tiia, Ayotte, Christiane, Boghosian, Thierry, Aikin, Reid, Sottas, Pierre-Edouard, Standardization of reticulocyte counts in the Athlete Biological Passport, Int J Lab Hematol, 2019, 41(3):387-391.
  5. Desharnais, Philippe, Naud, Jean-François and Christiane Ayotte, Detection of Erythropoiesis Stimulating Agents in urine samples using a capillary Western system, Drug Test Anal., 2018, (11-12):1698-1707.
  6. Desharnais, Philippe, Naud, Jean-François and Christiane Ayotte, Immunomagnetic beads-based isolation of erythropoietins from urine and blood for sports anti-doping control, Drug Test Anal., 2017, (11-12):1744-1752
  7. Desharnais, Philippe, Naud, Jean-François and Christiane Ayotte, Desialylation improves the detection of recombinant erythropoietins in urine samples analyzed by SDS-PAGE, Drug Test Anal., 2013, (11-12):870-6
  8. Beaulieu, Marie-Eve, McDuff, François-Olivier, Frappier, V, Montagne, Martin, Naud, Jean-François and Pierre Lavigne, New structural determinants for c-Myc specific heterodimerization with Max and development of a novel homodimeric c-Myc b-HLH-LZ, J. Mol. Recognit., 2012, 25(7): 414-426.
  9. Herkert, Barbara, Dwertmann, Anne, Herold, Steffi, Naud, Jean-Francois, Finkernagel, Florian, Harms, Gregory S., Wanzel, Michael and Martin Eilers, The Arf tumor supressor protein antagonizes Miz1 function to supress cell adhésion and induce apoptosis, J. Cell Biol.., 2010, 188(6): 905-918.
  10. McDuff, François-Olivier, Naud, Jean-François, Montagne, Martin, Sauvé, Simon and Pierre Lavigne, The Max homodimeric b-HLH-LZ significantly interferes with the specific heterodimerization between the c-Myc and Max b-HLH-LZ in absence of DNA: A quantitative analysis, 2009, J Mol Recognit., 22(4): 261-9
  11. Montagne, Martin, Naud, Jean-Francois and Pierre Lavigne, Elucidation of the structural determinants responsible for the specific formation of heterodimeric Mxd1/Max b-HLH-LZ and its binding to E-box sequences, 2008, J Mol Biol., 376(1): 141-52
  12. Meier-Andrejszki, Laura, Bjelic, Sasa, Naud, Jean-Francois, Lavigne, Pierre, and Ilian Jelesarov, Thermodynamics of b-HLH-LZ protein binding to DNA, The energetic importance of protein-DNA contacts in site-specific E-box recognition by the complete gene product of the Max p21 transcription factor, 2007, Biochemistry, 46(43): 12427-40.
  13. Naud, Jean-Francois and Martin Eilers, PIM1 and Myc: a changing relationship?, 2007, Nat. Cell Biol., 9 (8), 873-875.
  14. Sauvé, Simon, Naud, Jean-Francois and Pierre Lavigne, Structural and dynamical determinants of specific b/HLH/LZ/ DNA interactions, 2007, Journal of Molecular Biology, 365(4),1163-75.
  15. Naud, Jean-François, McDuff, François-Olivier, Sauvé, Simon, Montagne, Martin, Webb, Bradley A., Smith, Steven P., Chabot, Benoit and Pierre Lavigne, Structural and Thermodynamical Characterization of the complete p21 Gene Product of Max, 2005, Biochemistry, 44(38), 12746-12758.
  16. Montagne, Martin, Naud, Jean-François, McDuff, François-Olivier and Pierre Lavigne, Toward the Elucidation of the Structural Determinants Responsible for the Molecular Recognition between Mad1 and Max, 2005, Biochemistry, 44(38), 12860-12869.
  17. Naud, Jean-François, Gagnon, Frédéric, Wellinger, Raymund, Chabot, Benoit and Pierre Lavigne, Improving the Thermodynamic Stability of the Leucine Zipper of Max Increases the Stability of its b-HLH-LZ:E-box complex, 2003, Journal of Molecular Biology, 326(5), 1577-1595.
  18. Naud, Jean-François and David M. Gibson, A New Coding Region Polymorphism of IgLC2, 2001, European Journal of Immunogenetics, 28(1), 97-99.

Poster presentations

1             Charlebois, Alain, Ayotte, Christiane, Naud, Jean-François, Replacing the paper documentation with electronic operation trails including the chain of custody of samples, processed samples, reagents, and reference materials, 2024, Manfred Donike Workshop, Cologne, Germany

2             Couture, Maxime, Barber, Andrew, Naud, Jean-François, Detection of Testosterone Esters in Serum by LC-MS/MS, 2024, Manfred Donike Workshop, Cologne, Germany.

  1. Soucy, Myriam, Sansoucy, Maxime, Morneau, Eric et Jean-François Naud, Étude in vitro de sept nouveaux métabolites du SR9011 par LC-MS/MS, 2023, Congrès Armand-Frappier.
  2. Desharnais, Philippe, Hamelin, Claudine, Stinfil, Charles Job, Hébert, Natalie, Ferrand, Pauline, Ayotte, Christiane and Jean-François Naud, Evaluation of a single-point calibrator for the adjustment of IGF-1 concentrations measured by Immulite immunoassay, 2022, Manfred Donike Workshop, Cologne, Germany.
  3. Desharnais, Philippe and Jean-François Naud, A modified Towbin transfer buffer for a simple, versatile, and sensitive detection of ESAs, 2022, Manfred Donike Workshop, Cologne, Germany
  4. Desharnais, Philippe, Ayotte, Christiane and Jean-François Naud, Development of a new method for the detection of ActRIIA-Fc and ActRIIB-Fc using capillary electrophoresis, Virtual poster session of Partnership for Clean Competition, 2021.
  5. Stinfil, Job Charles, Chapot, Raphaël, Desharnais, Philippe, Naud, Jean-François and Christiane Ayotte, Decreased P-111-NP concentration rneasurement in hemolysed serum samples and its effect on the GH-Score, 2017, Manfred Donike Workshop, Cologne, Germany
  6. Stinfil, Job Charles, Naud, Jean-François, Desharnais, Philippe and Christiane Ayotte, Evaluation of the restandardized insulin-Like growth factor-1 (IGF-1) assay for the biomarkers test, 2017, Manfred Donike Workshop, Cologne, Germany
  7. Desharnais, Philippe, Naud, Jean-François and Christiane Ayotte, Single-blotting for ESA analysis of serurn/plasma samples by IEF and SAR-PAGE after immunomagnetic beadsisolation, 2017, Manfred Donike Workshop, Cologne, Germany
  8. Desharnais, Philippe, Chapot, R., Naud, Jean-François and Christiane Ayotte, Comparative study of the EPO-immunoaffinity approaches used for anti-doping control purposes, 2015, Manfred Donike Workshop, Cologne, Germany
  9. Desharnais, Philippe, Naud, Jean-François and Christiane Ayotte, Desialysation improves the detection of recombinant erythropoietins in urine samples by SDS-PAGE., 2012, Manfred Donike Workshop, Cologne, Germany
  10. Naud, J.F., Beaulieu, M.E., Lavigne, P and Martin Eilers, DNA binding in the Myc/Miz1 complex, EPFL Life Science Symposium, 2008, Lausanne, Suisse.
  11. Naud, J.F., Montagne, M., McDuff, F.O., Chabot, B. and Pierre Lavigne, Structural and thermodynamical analysis of the complete p21 gene product of Max, 18th Symposium of the Protein Society, 2004, San Diego, California, USA.
  12. Montagne, M., Naud, J.F., McDuff, F.O. and Pierre Lavigne, Elucidation of the Structural Determinants of the Molecular Recognition between Mad1 and Max, 18th Symposium of the Protein Society, 2004, San Diego, California, USA.
  13. Naud, J.F., Montagne, M., McDuff, F.O., Chabot, B. et Pierre Lavigne, 4e Symposium du CREFSIP, 2004, Quebec, Quebec, Canada.
  14. Naud, J.F., Montagne, M., McDuff, F.O., Chabot, B. and Pierre Lavigne, Structural and thermodynamical analysis of the complete p21 gene product of Max, 4th International Conference of the Canadian Proteomics Initiative, 2004, Montreal, Quebec, Canada.
  15. McDuff, F.O., Naud, J.F. and Pierre Lavigne, Molecular recognition between the c-Myc and Max b-HLH-LZ and the NMR backbone assignments of the b-HLH-LZ of c-Myc, 4th International Conference of the Canadian Proteomics Initiative, 2004, Montreal, Quebec, Canada.

Proceedings and book chapters

  1. Soucy M, Morneau É, Ricard S, Daoust B, Sansoucy M, Naud J-F, In vitro SR9011 metabolism study using tandem mass spectrometry, 2024, Recent Advances In Doping Analysis (32), Sport und Buch Strauß, under revision
  2. Barber, A, Naud, JF, Ayotte, C, GC-C-IRMS confirmation of Boldenone across sample matrices, 2024, Recent Advances In Doping Analysis (32), Sport und Buch Strauß, under revision
  3. Charlebois, A, Ayotte, C, Naud, JF, Replacing the paper documentation with electronic operation trails including the chain of custody of samples, processed samples, reagents, and reference materials, 2024, Recent Advances In Doping Analysis (32), Sport und Buch Strauß, under revision
  4. Couture, M, Barber, A, Naud, JF, Detection of Testosterone Esters in Serum by LC-MS/MS, 2024, Recent Advances In Doping Analysis (32), Sport und Buch Strauß, under revision
  5. Naud, J, Detection of activin receptor type IIA and II-B-Fc fusion proteins by automated capillary immunoassay, 2022, Recent Advances In Doping Analysis (30), Sport und Buch Strauß, under press
  6. Desharnais, Philippe, Hamelin, Claudine, Stinfil, Charles Job, Hébert, Natalie, Ferrand, Pauline, Ayotte, Christiane and Jean-François Naud, Evaluation of a single-point calibrator for the adjustment of IGF-1 concentrations measured by Immulite immunoassay, 2022, Recent Advances In Doping Analysis (30), Sport und Buch Strauß, under press
  7. Desharnais, Philippe and Jean-François Naud, A modified Towbin transfer buffer for a simple, versatile, and sensitive detection of ESAs, 2022, Recent Advances In Doping Analysis (30), Sport und Buch Strauß, under press
  8. Dehnes Y, Miller G, Naud J, Martin L, Reihlen P, Reichel C, Inter-laboratory validation of biotinylated clone AE7A5EPO- antibody for EPO detection by single blotting of urine and blood samples, 2021, Recent Advances In Doping Analysis (29), Sport und Buch Strauß, 194
  9. Naud J, Desharnais P, Ayotte C, Development of a capillary‐electrophoresis method for the detection of recombinant erythropoietins, 2018, Recent Advances In Doping Analysis (26). Sport und Buch Strauß, 49‐57
  10. Stinfil JC, Chapot R, Desharnais P, Naud J, Ayotte C, Decreased P‐III‐NP concentration measurement in hemolysed serum samplesand its effect on GH‐Score, 2017, Recent Advances In Doping Analysis (25). Sport und Buch Strauß, 124‐127
  11. Stinfil JC, Naud JF, Desharnais P, Ayotte C, Evaluation of the restandardized insulin‐Like growth factor‐I (IGF‐I) assay for the biomarkers test, 2017, Recent Advances In Doping Analysis (25). Sport und Buch Strauß, 105‐108
  12. Desharnais P, Naud JF, Ayotte C, Single‐blotting for ESA analysis of serum/plasma samples by IEF and SARPAGE after immunomagnetic beads isolation, 2017 Recent Advances In Doping Analysis (25). Sport und Buch Strauß, 109‐114
  13. Desharnais P, Chapot R, Naud J, Ayotte C, Comparative study of the EPO‐immunoaffinity approaches used for anti‐doping control purposes, 2015, Recent Advances In Doping Analysis (23). Sport und Buch Strauß

122‐125

  1. Naud J, Julien A, Ayotte C, Statistical analysis of the hGH recombinant and pituitary ratios obtained from routine testing of athletes samples with the CMZ isoform kits, 2014, Recent Advances In Doping Analysis (22). Sport und Buch Strauß, 63 – 67
  2. Desharnais P, Naud JF, Ayotte C, Desialylation improves the detection of recombinant erythropoietins in urine samples analyzed by SDS-PAGE, 2012, Recent Advances In Doping Analysis (20). Sport und Buch Strauß, 103-109