Looking for students or interns
Areas of expertise
Dynamic chemistry, bioorganic chemistry and biomaterials
- Full Professor
- Holder of the INRS Chair in Nanobiophotonics
- FRQS Senior Reseach Scholar
- Member of the NSERC CREATE network PrEEmium
- Member of the NSERC CREATE network ContRoL
Phone
514-228-6932
E-mail
marc.andre.gauthier@inrs.ca
Énergie Matériaux Télécommunications Research Centre
Our laboratory is located on the INRS Laval Campus at:
531 Boulevard des Prairies, Building 70, Laval, Quebec H7V 1B7, Canada
Accessible from Montreal by bus, metro, or car
Exact location of our laboratory (same building as the Quebec Biotechnology Innovation Center; CQIB).
Research interests
Global trends in pharmaceutics suggest that biomacromolecules such as proteins and nucleic acids will be among the drugs of the future. This is, in part, because they can catalyze specific reactions, bind to targets, modulate protein expression and protein–protein interactions, edit genes, etc. These mechanisms of action are typically not available to small-molecule drugs, which provides interesting opportunities for treating ‘undruggable’ diseases. Moreover, these molecules can be engineered by editing their amino/nucleic acid sequence or by chemical modification to tune properties. This offers exciting opportunities for exploring structure–activity relationships, elucidating new biophysical phenomena, characterizing mechanisms of action, and developing new tools for biotechnology.
Over the last six years, my group has navigated this research space along three major research axes. Our first has consolidated a platform of ‘molecular sieving’ polymer coatings for immunogenic anti-cancer enzymes, to preserve activity while isolating them from the immune system. We have been the first to demonstrate that branched polymers grafted to proteins can yield discontinuous coatings with tunable nanoscale pores. We have extensively characterized the molecular sieving properties of these coatings in vitro, in vivo, and in silico, and have developed predictive tools for de novo coatings [Small Methods 2025, Mater Today Chem 2022 & 2019, from original work in Nature Commun 2014, Adv Funct Mater 2013].1-5 Our second established a modular DNA nanotechnology platform to rapidly make anti-cancer bispecific antibodies (bsAb). We developed the synthetic/analytical framework to prepare libraries of DNA nanostructures bearing multiple protein ligands at precise locations, and have tested these constructs as scavengers for toxic amyloid proteo-species and as bispecific T-cell engagers [Aggregate 2024, J Am Chem Soc 2024 & 2019].6-8 We have also used this platform in an ultrasensitive quantum biosensor [Nano Letters 2025].9 Our third, more general, deepened our knowledge of the biophysics of bioconjugates through a portfolio of projects, to search for new phenomena and elusive properties and thus remain avant-garde in the field. We have developed new reactions to reversibly conjugate polymers to proteins,10, 11 studied the mechanisms of protein inactivation caused by polymer grafting,5, 12 and explored new routes for modulating protein–protein and protein–polymer interactions in solution.13-15 In the wake of covid-19, we equally explored routes for inactivating viruses by stimulating long-range collective vibrations of their capsids using femtosecond lasers (collaborative research)16, 17 and developed self-sanitizing/self-cleaning coatings for frequently touched surfaces (and founded Nanosaber Coating Technologies Inc.).18 Finally, we developed a long-acting bioconjugate with neuroprotective properties, and I led the European consortium (project GOTTARG) to validate its mechanism of action in rats and non-human primates,19-22 showing promise for humans. Overall, we have invested strongly in pushing the boundaries of bioconjugate design, production, analytics, and control.
Training openings for students or interns
We are interested in academic research, academic–industry partnerships, contract research, consulting, and providing analytical services in many areas that include:
Bioconjugates & Therapeutics
Therapeutic bioconjugates (peptides, proteins, nucleic acids)
Polymer–protein conjugation (PEGylation, Reversible PEGylation, Linkers)
Molecular sieving coatings (immune-protective coatings)
Biophysics of bioconjugates (mechanisms of inactivation, in silico predictions)
Multi-cyclic peptide folding (controlled disulfide pairing)
Bioconjugate manufacturing & analytics
Stimuli responsive bioconjugates (pH, redox, oxidative stress)
Enzyme therapeutics
DNA Nanotechnology & Molecular Engineering
DNA nanostructures, DNA nanotechnology, DNA switches
Microwave/RF responsive biomaterials
DNA based amyloid scavengers
Bispecific antibody assembly via DNA scaffolds
DNA–graphene biosensors/biosensing
Dynamic Covalent Chemistry & Bioconjugate Chemistry
Reversible covalent bioconjugation
Cysteine, methionine, and arginine selective conjugation
Responsive linkers
Biophysical & Mechanistic Characterization
Complex assay development
Nanoscale polymer buffering effects
Excluded volume & molecular crowding phenomena
Antimicrobial & Antiviral Strategies
Laser induced viral inactivation
Nanostructured self sanitizing surfaces
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Publications
| Title | Cited by | Year | |
| Detection of Obliterated Traceability Elements in Polypropylene through Strain-Induced Photoluminescence Variations
L Skokan, Y González, D Gueckelhorn, MA Gauthier, C Muehlethaler, … Analytical Chemistry 98 (7), 5344-5352 |
2026 | ||
| A General Approach to Predict and Tailor the Nanoscale Permeability of Comb‐Shaped Polymer Coatings
N Drossis, MA Gauthier, HW de Haan Small Methods 9 (7), 2500140 |
2025 | ||
| A Hybrid Molecule/Graphene van der Waals Heterostructure for DNA Immobilization and Detection
Z Yang, AA Greschner, L Skokan, A Ruediger, O Sedlacek, … Nano Letters 25 (22), 8884-8891 |
1 | 2025 | |
| Direct quantification of PEGylation for intact bioconjugates and nanoparticles by the colorimetric barium/iodide assay
K Coutu, A Ngabonziza Sangwa, N Gaudreault, SS Tayebi, T Hoare, … Biomacromolecules 26 (6), 3689-3699 |
2 | 2025 | |
| Void engineering to promote the self-cleaning properties of bactericidal zinc oxide nanopillar array coatings
A Hassanpour, MC Groleau, D Messaoudi, AA Greschner, K Kohlmann, … Materials Advances 6 (14), 4687-4695 |
1 | 2025 | |
| Preclinical validation of human recombinant glutamate-oxaloacetate transaminase for the treatment of acute ischemic stroke
M Pérez-Mato, A Dopico-López, Y Akkoc, S López-Amoedo, … Iscience 27 (11) |
5 | 2024 | |
| Rapid Systematic Screening of Bispecific Antibody Surrogate Geometries for T-Cell Engagement Using DNA Nanotechnology
S Messaoudi, K Wai, A Marple, SF Baniahmad, RG Wylie, M Pelletier, … Journal of the American Chemical Society 146 (43), 29824-29835 |
4 | 2024 | |
| Stability of a multiresponsive sulfonium vinyl sulfide linker toward nucleophilic/radical thiols, reactive nitrogen species, and in cells under pro-inflammatory stimulation
F Zare, P Laplante, AA Greschner, JF Cailhier, MA Gauthier Biomacromolecules 25 (9), 6017-6025 |
3 | 2024 | |
| Harnessing Water Competition to Drive Enzyme Crosstalk
A Meziadi, V Bloquert, AA Greschner, HW de Haan, MA Gauthier Biomacromolecules 25 (9), 6072-6081 |
2024 | ||
| Synthetic peptide shuttle agent bioconjugates for intracellular cargo delivery
AH SOULTAN, D Guay, JP LEPETIT-STOFFAES, T DEL’GUIDICE, … US Patent App. 18/553,178 |
2 | 2024 | |
| DNA nanostructures prevent the formation of and convert toxic amyloid proteospecies into cytocompatible and biodegradable spherical complexes
N Kihal, PT Nguyen, A Nazemi, AA Greschner, MA Gauthier, S Bourgault Aggregate 5 (3), e502 |
11 | 2024 | |
| Ion-retention properties of graphene oxide/zinc oxide nanocomposite membranes at various pH and temperature conditions
A Hassanpour, MA Gauthier, S Sun Scientific Reports 14 (1), 1443 |
5 | 2024 | |
| Nanoporcupine, method of manufacture and use thereof
A HASSANPOUR, MA GAUTHIER, S Sun, MC GROLEAU, E Deziel US Patent App. 18/312,665 |
1 | 2023 | |
| PEGylation of a peptide-based amphiphilic delivery agent and influence on protein delivery to cells
AA Greschner, N Brahiti, M Auger, L Hu, H Soleymani Abyaneh, … Biomacromolecules 24 (11), 4890-4900 |
15 | 2023 | |
| Correction to “Consecutive Alkylation,“Click”, and “Clip” Reactions for the Traceless Methionine-Based Conjugation and Release of Methionine-Containing Peptides”
F Zare, A Potenza, AA Greschner, MA Gauthier Biomacromolecules 24 (6), 2955-2956 |
2023 | ||
| Microwave-Induced Transient Heating Accelerates Protein PEGylation
A Meziadi, AA Greschner, MA Gauthier Biomacromolecules 24 (6), 2856-2863 |
1 | 2023 | |
| Overcoming PEG─ Protein Mutual Repulsion to Improve the Efficiency of PEGylation
A Meziadi, N Zuberi, HW de Haan, MA Gauthier Biomacromolecules 23 (11), 4948-4956 |
6 | 2022 | |
| Consecutive Alkylation,“Click”, and “Clip” Reactions for the Traceless Methionine-Based Conjugation and Release of Methionine-Containing Peptides
F Zare, A Potenza, AA Greschner, MA Gauthier Biomacromolecules 23 (7), 2891-2899 |
6 | 2022 | |
| Elucidating the mechanisms of the molecular sieving phenomenon created by comb-shaped polymers grafted to a protein–a simulation study
N Drossis, MA Gauthier, HW de Haan Materials Today Chemistry 24, 100861 |
9 | 2022 | |
| Aqueous Zn‐based rechargeable batteries: recent progress and future perspectives
M Wu, G Zhang, H Yang, X Liu, M Dubois, MA Gauthier, S Sun InfoMat 4 (5), e12265 |
173 | 2022 | |
| New perspectives for developing therapeutic bioconjugates of metabolite-depleting enzymes: Lessons learned combating glutamate excitotoxicity
A Zaghmi, M Perez-Mato, A Dopico-López, M Candamo-Lourido, … Biomacromolecules 23 (5), 1864-1872 |
9 | 2022 | |
| Noninvasive, label‐free, and quantitative monitoring of lipase kinetics using terahertz emission technology
S Nahar, A Mohamed, X Ropagnol, A Hassanpour, T Kiwa, T Ozaki, … Biotechnology and Bioengineering 118 (11), 4246-4254 |
6 | 2021 | |
| Nanostructured metal borides for energy‐related electrocatalysis: recent progress, challenges, and perspectives
Z Pu, T Liu, G Zhang, X Liu, MA Gauthier, Z Chen, S Sun Small Methods 5 (10), 2100699 |
96 | 2021 | |
| Treating brain diseases using systemic parenterally-administered protein therapeutics: Dysfunction of the brain barriers and potential strategies
A Zaghmi, J Drouin-Ouellet, D Brambilla, MA Gauthier Biomaterials 269, 120461 |
18 | 2021 | |
| Sustained blood glutamate scavenging enhances protection in ischemic stroke
A Zaghmi, A Dopico-López, M Pérez-Mato, R Iglesias-Rey, P Hervella, … Communications biology 3 (1), 729 |
34 | 2020 | |
| Comparative study on the inactivation of MS2 and M13 bacteriophages using energetic femtosecond lasers
A Berchtikou, E Sokullu, S Nahar, P Tijssen, MA Gauthier, T Ozaki Journal of Biophotonics 13 (10), e202000109 |
5 | 2020 | |
| Plasmonic enhancement of two-photon excitation fluorescence by colloidal assemblies of very small AuNPs templated on M13 phage
E Sokullu, M Pinsard, J Zhang, J Plathier, G Kolhatkar, AS Blum, F Légaré, … Biomacromolecules 21 (7), 2705-2713 |
8 | 2020 | |
| The phage display of Bacillus subtilis Lipase A significantly enhances catalytic activity due to altered nanoscale distribution in colloidal solution
S Nahar, E Sokullu, MA Gauthier Biotechnology and bioengineering 117 (3), 868-872 |
6 | 2020 | |
| Cascaded optical polymer waveguide for enhanced fluorescence evanescent wave spectroscopy
J Abdul-Hadi, MA Gauthier, M Packirisamy Optics & Laser Technology 123, 105904 |
4 | 2020 | |
| Photocatalytic interlayer spacing adjustment of a graphene oxide/zinc oxide hybrid membrane for efficient water filtration
A Hassanpour, S Nahar, X Tong, G Zhang, MA Gauthier, S Sun Desalination 475, 114174 |
41 | 2020 | |
| Accelerated inactivation of M13 bacteriophage using millijoule femtosecond lasers
A Berchtikou, AA Greschner, P Tijssen, MA Gauthier, T Ozaki Journal of Biophotonics 13 (2), e201900001 |
10 | 2020 | |
| Towards extracellular matrix normalization for improved treatment of solid tumors
HS Abyaneh, M Regenold, TD McKee, C Allen, MA Gauthier Theranostics 10 (4), 1960 |
122 | 2020 | |
| Surface vs. core N/S/Se-heteroatom doping of carbon nanodots produces divergent yet consistent optical responses to reactive oxygen species
X Geng, TR Congdon, P Anees, AA Greschner, F Vetrone, MA Gauthier Nanoscale Advances 2 (9), 4024-4033 |
5 | 2020 | |
| In vivo properties of therapeutic bioconjugates composed of proteins and architecturally/functionally complex polymers
A Zaghmi, AA Greschner, MA Gauthier Polymer-Protein Conjugates, 389-406 |
5 | 2020 | |
| Homogenous Scavenging Resolves Low-Purification Yield/Selectivity Caused by Secondary Binding of Protein-A to Antigen-Binding Antibody Fragments
P Anees, MA Gauthier Biomacromolecules 21 (2), 825-829 |
2 | 2019 | |
| Progress toward absorption, distribution, metabolism, elimination, and toxicity of DNA nanostructures
S Messaoudi, AA Greschner, MA Gauthier Advanced Therapeutics 2 (12), 1900144 |
21 | 2019 | |
| Ultra-sub-stoichiometric “Dynamic” Bioconjugation Reduces Viscosity by Disrupting Immunoglobulin Oligomerization
Y Gong, H Soleymani Abyaneh, N Drossis, A Niederquell, M Kuentz, … Biomacromolecules 20 (9), 3557-3565 |
4 | 2019 | |
| Determination of the degree of PEGylation of protein bioconjugates using data from proton nuclear magnetic resonance spectroscopy
A Zaghmi, AA Greschner, E Mendez-Villuendas, JY Liu, HW de Haan, … Data in brief 25, 104037 |
14 | 2019 | |
| Mechanisms of activity loss for a multi-PEGylated protein by experiment and simulation
A Zaghmi, E Mendez-Villuendas, AA Greschner, JY Liu, HW De Haan, … Materials Today Chemistry 12, 121-131 |
62 | 2019 | |
| Plant/bacterial virus-based drug discovery, drug delivery, and therapeutics
E Sokullu, H Soleymani Abyaneh, MA Gauthier Pharmaceutics 11 (5), 211 |
60 | 2019 | |
| Chemical vapour deposition of graphene: Layer control, the transfer process, characterisation, and related applications
X Yang, G Zhang, J Prakash, Z Chen, M Gauthier, S Sun International Reviews in Physical Chemistry 38 (2), 149-199 |
74 | 2019 | |
| Bio-conjugate approaches to mAb manufacturing
A Palapuravan, Y Gong, H Soleymani, Y Zhao, A Greschner, T Congdon, … ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 257 |
2019 | ||
| Room-temperature and selective triggering of supramolecular DNA assembly/disassembly by nonionizing radiation
AA Greschner, X Ropagnol, M Kort, N Zuberi, J Perreault, L Razzari, … Journal of the American Chemical Society 141 (8), 3456-3469 |
50 | 2019 | |
| Ultra-sub-stoichiometric
Y Gong, N Drossis, A Niederquell, M Kuentz, JC Leroux, HW de Haan, … Biomacromolecules |
2019 | ||
| Precise orientation of thermally-sensitive biomolecules using DNA nanostructures: An exploration of non-thermal techniques for controlling DNA nanoassemblies
A Greschner, X Ropagnol, M Kort, N Zuberi, J Perreault, L Razzari, … JACS 141 (8), 3456-3469 |
2019 | ||
| Evidence, manipulation, and termination of pH ‘Nanobuffering’for quantitative homogenous scavenging of monoclonal antibodies
P Anees, Y Zhao, AA Greschner, TR Congdon, HW de Haan, N Cottenye, … ACS nano 13 (2), 1019-1028 |
24 | 2018 | |
| Polymer on quartz waveguide sensing platform for enhanced evanescent fluorescence spectroscopy
J Abdul-Hadi, MA Gauthier, M Packirisamy IEEE Photonics Journal 10 (6), 1-15 |
6 | 2018 | |
| Ferroelectric tunnel junction and method of fabrication thereof
A Ruediger, F Ambriz-Vargas, G Kolhatkar, R Thomas, AH Youssef, … US Patent 10,056,394 |
2 | 2018 | |
| Silicon-free, low-loss and high contrast polymer multimode waveguides
J Abdul-Hadi, MA Gauthier, M Packirisamy Journal of Micromechanics and Microengineering 27 (10), 105006 |
6 | 2017 | |
| Stimuli-responsive protein-polymer conjugates for bioseparation
C Kent, W Baille, M Gauthier, Y Zhao, N COTTENYE US Patent App. 15/515,936 |
4 | 2017 | |
| Extreme nonlinear carrier dynamics induced by intense quasi-half-cycle THz pulses in n-doped InGaAs thin film
X Chai, X Ropagnol, M Raeiszadeh, S Safavi-Naeini, M Reid, … CLEO: QELS_Fundamental Science, FW1H. 3 |
2 | 2017 | |
| A complementary metal oxide semiconductor process-compatible ferroelectric tunnel junction
F Ambriz-Vargas, G Kolhatkar, M Broyer, A Hadj-Youssef, R Nouar, … ACS applied materials & interfaces 9 (15), 13262-13268 |
231 | 2017 | |
| Tunneling electroresistance effect in a Pt/Hf0. 5Zr0. 5O2/Pt structure
F Ambriz-Vargas, G Kolhatkar, R Thomas, R Nouar, A Sarkissian, … Applied Physics Letters 110 (9) |
144 | 2017 | |
| Influence of gap size on intense THz generation from ZnSe interdigitated large aperture photoconductive antennas (October 2016)
X Ropagnol, X Chai, SM Raeis-Zadeh, S Safavi-Naeini, M Kirouac-Turmel, … IEEE Journal of Selected Topics in Quantum Electronics 23 (4), 1-8 |
8 | 2017 | |
| RF-magnetron sputtering deposition of ultra-thin Hf0. 5Zr0. 5O2 films for non-volatile memory applications
F Ambriz-Vargas, R Nouar, G Kolhatkar, A Sarkissian, R Thomas, … Materials Today: Proceedings 4 (7), 7000-7010 |
6 | 2017 | |
| Synthesis and characterization of thin-transparent nanostructured films for surface protection
S Veltri, E Sokullu, M Barberio, MA Gauthier, P Antici Superlattices and Microstructures 101, 209-218 |
9 | 2017 | |
| Releasable and traceless PEGylation of arginine-rich antimicrobial peptides
Y Gong, D Andina, S Nahar, JC Leroux, MA Gauthier Chemical science 8 (5), 4082-4086 |
53 | 2017 | |
| In vitro and in vivo evaluation of PEGylated layer‐by‐layer polyelectrolyte‐coated paclitaxel nanocrystals
A Polomska, MA Gauthier, JC Leroux Small 13 (2), 1602066 |
43 | 2017 | |
| Nonlinear ultrafast terahertz waveform modulation in highly n-doped In0.53Ga0.47As thin film
X Chai, X Ropagnol, M Raeiszadeh, S Safavi-Naeini, M Reid, … 2016 41st International Conference on Infrared, Millimeter, and Terahertz … |
2016 | ||
| Asymmetric half-cycle THz pulses with large ponderomotive potential generated from photoconductive antennas
X Ropagnol, M Raeiszadeh, S Safavi-Naeini, M Reid, MA Gauthier, … 2016 41st International Conference on Infrared, Millimeter, and Terahertz … |
1 | 2016 | |
| P1‐076: Development of Bio‐Conjugates for the Treatment of Excitotoxicity During Alzheimer’s Disease
A Zaghmi, A Greschner, MA Gauthier, C Ramassamy Alzheimer’s & Dementia 12, P431-P431 |
2016 | ||
| Dependence of intense THz generation on gap size from ZnSe interdigitated large aperture photoconductive antennas
X Ropagnol, SM Raeis-Zadeh, S Safavi-Naeini, M Bouvier, CY Côté, … CLEO: Applications and Technology, JTh2A. 64 |
2 | 2016 | |
| Intense THz pulses with large ponderomotive potential generated from large aperture photoconductive antennas
X Ropagnol, M Khorasaninejad, M Raeiszadeh, S Safavi-Naeini, … Optics express 24 (11), 11299-11311 |
77 | 2016 | |
| Biomedical applications of polymers made from natural compounds
Y Jia, K Wang, F Le Devedec, S Strandman, MA Gauthier, JE Gautrot, … ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 251 |
2016 | ||
| Correction: Corrigendum: Sustained gastrointestinal activity of dendronized polymer–enzyme conjugates
G Fuhrmann, A Grotzky, R Lukić, S Matoori, P Luciani, H Yu, B Zhang, … Nature Chemistry 8 (3), 281-281 |
2016 | ||
| PEG-Enzyme for neurodegenerative diseases treatment
A Zaghmi, A Greschner, C Ramassamy, MA Gauthier |
2016 | ||
| Les bio-conjugues pour le traitement de la maladie d’Alzheimer
A Zaghmi, A Greschner, C Ramassamy, MA Gauthier |
2016 | ||
| Nano-engineered electro-responsive drug delivery systems
Y Zhao, AC Tavares, MA Gauthier Journal of Materials Chemistry B 4 (18), 3019-3030 |
105 | 2016 | |
| Preparation and characterization of nanostructured films: study of hydrophobicity and antibacterial properties for surface protection
M Barberio, S Veltri, E Sokullu, F Xu, MA Gauthier, P Antici Advanced Processing and Manufacturing Technologies for Nanostructured and … |
1 | 2015 | |
| Site-Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract.
JD Schulz, M Patt, S Basler, H Kries, D Hilvert, MA Gauthier, JC Leroux Advanced materials (Deerfield Beach, Fla.) 28 (7), 1455-1460 |
49 | 2015 | |
| Improving oral drug bioavailability with polycations?
JD Schulz, MA Gauthier, JC Leroux European Journal of Pharmaceutics and Biopharmaceutics 97, 427-437 |
50 | 2015 | |
| Conformation–function relationships for the comb-shaped polymer pOEGMA
M Liu, JC Leroux, MA Gauthier Progress in polymer science 48, 111-121 |
83 | 2015 | |
| The interplay of disulfide bonds, α-helicity, and hydrophobic interactions leads to ultrahigh proteolytic stability of peptides
Y Chen, C Yang, T Li, M Zhang, Y Liu, MA Gauthier, Y Zhao, C Wu Biomacromolecules 16 (8), 2347-2355 |
33 | 2015 | |
| Releasable conjugation of polymers to proteins
Y Gong, JC Leroux, MA Gauthier Bioconjugate chemistry 26 (7), 1172-1181 |
88 | 2015 | |
| Generation of elliptically polarized half-cycle terahertz pulses generated by 6H-SiC large aperture photoconductive antenna
X Ropagnol, M Bouvier, CY Côté, M Reid, MA Gauthier, T Ozaki 2015 Conference on Lasers and Electro-Optics (CLEO), 1-2 |
1 | 2015 | |
| Twin disulfides as opportunity for improving stability and transfection efficiency of oligoaminoethane polyplexes
PM Klein, K Müller, C Gutmann, P Kos, AK Levacic, D Edinger, M Höhn, … Journal of Controlled Release 205, 109-119 |
53 | 2015 | |
| Disulfide-containing parenteral delivery systems and their redox-biological fate
L Brülisauer, MA Gauthier, JC Leroux Journal of Controlled Release 195, 147-154 |
232 | 2014 | |
| Semi-permeable coatings fabricated from comb-polymers efficiently protect proteins in vivo
M Liu, P Johansen, F Zabel, JC Leroux, MA Gauthier Nature communications 5 (1), 5526 |
81 | 2014 | |
| Bio‐reduction of Redox‐Sensitive Albumin Conjugates in FcRn‐Expressing Cells
L Brülisauer, G Valentino, S Morinaga, K Cam, J Thostrup Bukrinski, … Angewandte Chemie 126 (32), 8532-8536 |
21 | 2014 | |
| Redox-responsive drug delivery
MA Gauthier Antioxidants & redox signaling 21 (5), 705-706 |
31 | 2014 | |
| Targeting of injectable drug nanocrystals
K Fuhrmann, MA Gauthier, JC Leroux Molecular pharmaceutics 11 (6), 1762-1771 |
87 | 2014 | |
| Complex single-chain polymer topologies locked by positionable twin disulfide cyclic bridges
O Shishkan, M Zamfir, MA Gauthier, HG Börner, JF Lutz Chemical Communications 50 (13), 1570-1572 |
63 | 2014 | |
| Modular design of redox-responsive stabilizers for nanocrystals
K Fuhrmann, A Połomska, C Aeberli, B Castagner, MA Gauthier, … ACS nano 7 (9), 8243-8250 |
68 | 2013 | |
| Polymer–Enzyme Conjugates for Oral Drug Delivery Applications: Polymer and Colloid Highlights
G Fuhrmann, MA Gauthier, JC Leroux Chimia 67 (9), 685-685 |
1 | 2013 | |
| Broad control of disulfide stability through microenvironmental effects and analysis in complex redox environments
C Wu, S Wang, L Brülisauer, JC Leroux, MA Gauthier Biomacromolecules 14 (7), 2383-2388 |
49 | 2013 | |
| Sustained gastrointestinal activity of dendronized polymer–enzyme conjugates
G Fuhrmann, A Grotzky, R Lukić, S Matoori, P Luciani, H Yu, B Zhang, … Nature chemistry 5 (7), 582-589 |
125 | 2013 | |
| Molecular sieving on the surface of a protein provides protection without loss of activity
M Liu, P Tirino, M Radivojevic, DJ Phillips, MI Gibson, JC Leroux, … Advanced Functional Materials 23 (16), 2007-2015 |
62 | 2013 | |
| New methacrylic monomers for dental applications
K Zhang, W Baille, M Gauthier, XX Zhu, S Lerouge, D Fortin |
2013 | ||
| Twin disulfides for orthogonal disulfide pairing and the directed folding of multicyclic peptides
C Wu, JC Leroux, MA Gauthier Nature chemistry 4 (12), 1044-1049 |
86 | 2012 | |
| Tracking the bioreduction of disulfide-containing cationic dendrimers.
L Brülisauer, N Kathriner, M Prenrecaj, MA Gauthier, JC Leroux Angewandte Chemie (International ed. in English) 51 (50), 12454-12458 |
80 | 2012 | |
| Lipase Is Essential for the Study of in Vitro Release Kinetics from Organogels
MH Dufresne, E Marouf, Y Kränzlin, MA Gauthier, JC Leroux Molecular pharmaceutics 9 (6), 1803-1811 |
14 | 2012 | |
| PEG nanocages as non-sheddable stabilizers for drug nanocrystals
K Fuhrmann, JD Schulz, MA Gauthier, JC Leroux ACS nano 6 (2), 1667-1676 |
76 | 2012 | |
| New pharmaceutical applications for macromolecular binders
N Bertrand, MA Gauthier, C Bouvet, P Moreau, A Petitjean, JC Leroux, … Journal of controlled release 155 (2), 200-210 |
56 | 2011 | |
| Interplay of chemical microenvironment and redox environment on thiol–disulfide exchange kinetics
C Wu, C Belenda, JC Leroux, MA Gauthier Chemistry–A European Journal 17 (36), 10064-10070 |
86 | 2011 | |
| Arginine-specific modification of proteins with polyethylene glycol
MA Gauthier, HA Klok Biomacromolecules 12 (2), 482-493 |
98 | 2011 | |
| Methacrylate derivatives of bile acids for use as monomers for dental resins
MA Gauthier, S Lerouge, D Fortin, XX Zhu |
2011 | ||
| Arginine-specific protein modification using α-oxo-aldehyde functional polymers prepared by atom transfer radical polymerization
MA Gauthier, M Ayer, J Kowal, FR Wurm, HA Klok Polymer Chemistry 2 (7), 1490-1498 |
18 | 2011 | |
| Crosslinkable polymers for nanocrystal stabilization
K Fuhrmann, MA Gauthier, JC Leroux Journal of Controlled Release 148 (1), e12-e13 |
12 | 2010 | |
| Polymer Chemistry
MA Gauthier, C Zhao |
1 | 2010 | |
| Polymer–protein conjugates: an enzymatic activity perspective
MA Gauthier, HA Klok Polymer chemistry 1 (9), 1352-1373 |
208 | 2010 | |
| New dental composites containing multimethacrylate derivatives of bile acids: a comparative study with commercial monomers
MA Gauthier, Z Zhang, XX Zhu ACS Applied Materials & Interfaces 1 (4), 824-832 |
43 | 2009 | |
| Dental resins and degradable elastomers made from natural compounds
MA Gauthier, JE Gautro, G Giguere, K Metera Program & Abstracts of the 4~(th) International Symposium on Engineering … |
2009 | ||
| Synthese funktioneller Polymere durch polymeranaloge Reaktionen
MA Gauthier, MI Gibson, HA Klok Angewandte Chemie 121 (1), 50-60 |
56 | 2009 | |
| Synthesis of functional polymers by post‐polymerization modification
MA Gauthier, MI Gibson, HA Klok Angewandte Chemie International Edition 48 (1), 48-58 |
1108 | 2009 | |
| Peptide/protein–polymer conjugates: synthetic strategies and design concepts
MA Gauthier, HA Klok Chemical Communications, 2591-2611 |
496 | 2008 | |
| Bile acids as constituents for dental composites: in vitro cytotoxicity of (meth) acrylate and other ester derivatives of bile acids
MA Gauthier, P Simard, Z Zhang, XX Zhu Journal of The Royal Society Interface 4 (17), 1145-1150 |
37 | 2007 | |
| New Polymer Materials for Dental Applications
M Gauthier Abstracts of the Third International Symposium on Engineering Plastics |
2007 | ||
| Large uniform-sized polymer beads for use as solid-phase supports prepared by ascension polymerization
XX Zhu, JH Zhang, M Gauthier, JT Luo, FS Meng, F Brisse Journal of Combinatorial Chemistry 8 (1), 79-84 |
8 | 2006 | |
| Développement et caractérisation de matériaux dentaires hautement performants
MA Gauthier |
2 | 2006 | |
| A new method for quantifying the intensity of the C= C band of dimethacrylate dental monomers in their FTIR and Raman spectra
MA Gauthier, I Stangel, TH Ellis, XX Zhu Biomaterials 26 (33), 6440-6448 |
113 | 2005 | |
| Dental materials containing bile acid derivatives
MA Gauthier, I Stangel, TH Ellis, XX Zhu ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 230, U4095-U4095 |
2005 | ||
| Oxygen inhibition in dental resins
MA Gauthier, I Stangel, TH Ellis, XX Zhu Journal of dental research 84 (8), 725-729 |
259 | 2005 | |
| Thiol-functionalized polymeric micelles: from molecular recognition to improved mucoadhesion
MH Dufresne, MA Gauthier, JC Leroux Bioconjugate chemistry 16 (4), 1027-1033 |
74 | 2005 | |
| Degree of crosslinking and mechanical properties of crosslinked poly (vinyl alcohol) beads for use in solid-phase organic synthesis
MA Gauthier, J Luo, D Calvet, C Ni, XX Zhu, M Garon, MD Buschmann Polymer 45 (24), 8201-8210 |
78 | 2004 | |
| Confocal Raman micro-spectroscopic study of monomer conversion of dental resins.
MA Gauthier, TH Ellis, I Stangel JOURNAL OF DENTAL RESEARCH 81, A84-A84 |
3 | 2002 |