Daniel G. Cyr

Areas of expertise

Effects of environmental contaminants on the male reproductive system , Toxicology, and Cell and Molecular Biology

  • INRS Professor

450 687-5010 x8833
450 686-5501
daniel.cyr@iaf.inrs.ca

Armand-Frappier Santé Biotechnologie Research Centre

531, boulevard des Prairies
Laval, Québec  H7V 1B7
CANADA

See research centre

Interested research topics

Our laboratory is interested understanding the role of cell-cell interaction in the epididymis and their importance in creating a luminal environment suitable for sperm maturation. We are also interested in the effects of environmental toxicants and their effects on cell-cell interaction and in the development and function of male reproductive function.

Regulation on intercellular communication

Intercellular gap junctions are essential structural components that allow direct communication between neighboring cells. Gap junctional communication is therefore critical for coordinating cellular function within complex epithelia. In the male reproductive tract, gap junctional communication is essential for the exchange of cellular messengers necessary for spermatogenesis in the testis and for the coordination of sperm maturation in the epididymis. A crucial aspect of sperm maturation is the fact that the epididymal epithelium must coordinate the different regions of epididymis in order to modify the luminal environment necessary for sperm maturation. Our objectives are to understand the role and regulation of gap junctional communication in the epididymis and the role of this cellular communication in sperm maturation. In the short-term objectives are to target the gap junctional proteins, connexins, and correlate their level of expression to both the physiological and structural integrity of the epididymis, in order understand the role of gap junctions in coordinating epithelial function and sperm maturation.

Epididymal tight junctions and the blood-epididymal barrier

The creation and maintenance of microenvironments within biological systems are crucial for the development and function of specialized cells within complex organisms. These microenvironments are created by tight junctions between cells which form an impenetrable seal, thereby forcing receptor mediated transport across cells and creating specific environments. These cellular barriers exist in the brain, retina, thymus, intestine, and kidney, as well as in male reproductive tissues such as the testis and epididymis. Understanding the regulation of proteins responsible for the maintenance of these barriers is necessary, as tight junctions undergo rapid alterations in diseases such as celiac disease, Crohn’s disease, renal diseases, asthma, cystic fibrosis and breast cancer. In male reproductive tissues, the microenvironments formed by tight junctions are essential for spermatogenesis in the testis and for sperm maturation in the epididymis. While unexplained male infertility results from multiple causes, studies in rats have shown that infertility in ageing males is accompanied by a loss of tight junctions in the epididymis. Given the crucial nature of tight junctions in both normal physiological processes and in widespread pathologies, including male infertility, our objective is to understand the factors regulating the formation of the tight junctions responsible for the formation of the blood-epididymal barrier, a key determinant of male fertility.

Effects of endocrine disruptors on fish reproduction

We have shown that fish in the St. Lawrence River are exposed to environmental estrogens. This contamination originates in the Ottawa River. Other sources of estrogenic contamination include the Montreal Urban Community’s sewage effluent. Contamination of aquatic ecosystems by estrogenic substances can be associated with a variety of chemical contaminants. While exposure to estrogenic contamination can be monitored by measuring the expression of vitellogenin (VTG) in male and immature fish, there has been relatively limited information on the significance of induced VTG on gonadal development and reproductive fitness in males. A difficulty in assessing the effects of endocrine disrupting chemicals (EDCs) on fish reproduction stems from the fact that there are a limited number of tools available to assess testicular development in fish. The development of such tools is critical for understanding the effects of EDCs on the testis. Given the extent of the contamination of the St. Lawrence by EDCs, and the site specific effects we have characterized in the past, this represents an ideal ecosystem model in which to develop tools needed to assess the effects of EDCs on the testis, and to establish specific effects associated with the contamination of the St. Lawrence. We have developed a variety of biomarkers to study the effects of EDCs on male reproduction. These include sperm motility, and markers of spermatogenesis and sex reversal. We have shown that sperm number and motility is altered in spottail shiners captured at sites where male shiners have elevated hepatic VTG mRNA levels. We are currently interested to further establish the effects of EDCs, on semen quality using a laboratory based approach and to determine the effects of EDCs on both spermatogenesis and sex determination using a field-based sampling approach

Dr. Cyr is a graduate of Concordia University where he received a B.Sc. (Hons) and M.Sc. (Biology) and from the University of Manitoba where he received a Ph.D. (Zoology). Following four years of postdoctoral studies at McGill University (Pharmacology), Dr. Cyr worked as a scientist for Health Canada (1992-93) and the Department of Fisheries and Oceans (1993-97).

Publications

2004-PRÉSENT

ARAM R, CHAN P, AND CYR DG. (2019)
Beta-Defensin126 is correlated with sperm motility in fertile and infertile patients
Biology of Reproduction (in press)

PINEL L, MANDON M., AND, CYR DG (2019)
Tissue regeneration and the epididymal stem cell.
Andrology 7:618-630

SANTOS BORGES C, MISSASSI G, FIGUEIREDO T, ARAUJO LEITE G, GREGORY M, CYR DG AND KEMPINAS WG. (2019)
Intergenerational effects of betamethasone on the development and structure of the rat epididymis.
Andrology 7:719-729.

GREGORY M AND CYR DG. (2019)
Prostaglandin E2 regulates the phosphorylation and cellular localizarion of connexin 43 in epididymal basal cells of the rat.
Biology of Reproduction  100:123-132.

GREGORY M AND CYR DG. (2019)
A special issue on the effects of toxicants on cellular junctions in development and reproduction.
Reproductive Toxicology (Editorial) 83: 80-81.

BOURGEOIS FR, MONETTE F, AND CYR DG. (2018)
Operational modifications for the development of nitrifying bacteria in a large-scale biological aerated filter and its impact on wastewater treatment.
Water Science and Technology 78:1704-1714.

CYR DG, DUFRESNE J, GREGORY M. (2018)
Cellular junctions in the epididymis, a critical parameter for understanding male reproductive toxicology.
Reproductive Toxicology 81: 207-219.

BORGES CS, PACHECOTL, SILVA PV, GREGORY M, PUPO AS, CYR DG, AND KEMPINAS WG. (2017)
Betamethasone causes intergenerational reproductive impairment in male rats.
Reproductive Toxicology 71:108-117.

BORGES CS, DIAS AFMG, ROSA JL, SILVA PV, SILVA RF, BARROS AL, SANABRIA M, GUERRA MT, GREGORY M, CYR DG & KEMPINAS WDG (2016).
Alterations in male rats following in utero exposure to betamethasone suggests changes in reproductive programming.
Reproductive Toxicology 63:125-134.

ADAM C & CYR DG (2016).
Role of Specificity Protein-1 and Activating Protein-2 Transcription Factors in the Regulation of the Gap Junction Protein Beta-2 Gene in the Epididymis.
Biology of Reproduction 94:120, 1–15.

OLIVEIRA RL, PARENT A, CYR DG, GREGORY M, MANDATO CA, SMITH CE, & HERMO L. (2016)
Implications of caveolae in testicular and epididymal myoid cells to sperm motility.
Molecular Reproduction and Development 83:526-540.

KIDDER GM & CYR DG. (2016)
Roles of connexins in testis development and function.
Seminars in Cell and Developmental Biology 50:22-30.

CYR, D.G. (2016)
Male reproductive toxicology and the role of immunohistochemistry.  In S. Aziz and R. Mehta (eds)
Technical Aspects of Toxicological Immunohistochemistry. Springer, New York pp 95-111.

CYR DG, DEVINE, P.J., & PLANTE, I. (2016)
Immunohistochemistry and female reproductive toxicology: the ovary and mammary gland.  In S. Aziz and R. Mehta (eds)
Technical Aspects of Toxicological Immunohistochemistry.  Springer, New York. pp 113-145.

MANDON,M., HERMO, L., & CYR DG (2015)
Isolated epididymal basal cells share common properties with adult stem cells.
Biology of Reproduction 93, 115.

COLLINS, M. M., BAUMHOLTZ, A. I., SIMARD, A., GREGORY, M., CYR, D. G. & RYAN, A. K. (2015)
Claudin-10 is required for relay of left-right patterning cues from Hensen’s node to the lateral plate mesoderm,
Developmental Biology, 401, 2, 236-248.

MARCOGLIESE, D.J., BLAISE, C., CYR, D., DeLAFONTAINE, Y., FOURNIER, M., GAGNÉ, F., GAGNON, C., HUDON, C. (2015)
Effects of a major municipal effluent on the St. Lawrence River: A case study
Ambio 44, 257.

MANDON, M., CYR, D.G. (2015)
Tricelulin and its role in the epididiymal epithelium of the rat
Biology of Reproduction 92, 66.

GREGORY, M., CYR, D.G. (2014)
The blood epididymis barrier and inflammation
Spermatogenesis 4, e979619.

DUFRESNE, J., CYR, D.G. (2014)
Regulation of the pannexin1 promoter in the rat epididymis.
Biology of Reproduction 143, 1-13.

ARSTIKAITIS, J., GAGNE, F. & CYR, D. G. (2014)
Exposure of fathead minnows to municipal wastewater effluent affects intracellular signaling pathways in the liver,
Comparative Biochemistry and Physiology. Toxicology and Pharmacology, 164C, 1-10.

CYR, D. G., LEE, K. H., MARCOGLIESE, D. J. & SANDERSON, J. T. (2013)
Recent advances in endocrine disruptors. IN BLAISE, C. & FERRARD , J. (Eds.) Comprehensive Handbook of Ecotoxicological Terms, New-York, Elsevier, vol 2, 781-796.

CHRISTIN, M. S., MÉNARD, L., GIROUX, I., MARCOGLIESE, D. J., RUBY, S., CYR, D., FOURNIER, M. & BROUSSEAU, P. (2013)
Effects of agricultural pesticides on the health of Rana pipiens frogs sampled from the field,
Environmental Science and Pollution Research International, 20, 2, 601-11.

DUBÉ, E., DUFRESNE, J., CHAN, P. T. K. & CYR, D. G. (2012)
Epidermal growth factor regulates connexin 43 in the human epididymis: role of gap junctions in azoospermia
Human Reproduction , 27, 8, 2285-2296.

DUBÉ, E. & CYR, D. G. (2012)
The blood-epididymis barrier and human male fertility,
Advances in Experimental Medicine and Biology, 763, 218-36.

BELLEANNÉE, C., CALVO, E., THIMON, V., CYR, D. G., LÉGARÉ, C., GARNEAU, L. & SULLIVAN, R. (2012)
Role of microRNAs in controlling gene expression in different segments of the human epididymis.
PLoS ONE , 7, 4, e34996.

TURMEL, P., DUFRESNE, J., HERMO, L., SMITH, C. E., PENUELA, S., LAIRD, D. W. & CYR, D. G. (2011)
Characterization of pannexin1 and pannexin3 and their regulation by androgens in the male reproductive tract of the adult rat
Molecular Reproduction and Development , 78, 2, 124-138.

JONES, S. R. & CYR, D. G. (2011)
Regulation and Characterization of the ATP-Binding Cassette Transporter-B1 in the Epididymis and Epididymal Spermatozoa of the Rat
Toxicological Sciences , 119, 2, 369-379.

GREGORY, M., KAHIRI, C. N., BARR, K. J., SMITH, C. E., HERMO, L., CYR, D. G. & KIDDER, G. M. (2011)
Male reproductive system defects and subfertility in a mutant mouse model of oculodentodigital dysplasia(1)
International Journal of Andrology , 34, 6pt2, e630-e641.

FOSTER, W. G., MAHARAJ-BRICENO, S. & CYR, D. G. (2011)
Dioxin-induced changes in epididymal sperm count and spermatogenesis
Ciencia e Saude Coletiva , 16, 6, 2893-905.

DE MONTGOLFIER, B., AUDET, C. & CYR, D. G. (2011)
Regulation of the connexin 43 promoter in the brook trout testis: Role of the thyroid hormones and cAMP
General and Comparative Endocrinology , 170, 1, 110-118.

CYR, D. G., DUBÉ, E., DUFRESNE, J. & GREGORY, M. (2011)
Development of biological tools to study claudins in the male reproductive tract
Methods in Molecular Biology , 762, 259-73.

CYR, D. G. (2011)
Connexins and pannexins: Coordinating cellular communication in the testis and epididymis
Spermatogenesis , 1, 4, 325-338.

BEDARD, N., YANG, Y. M., GREGORY, M., CYR, D. G., SUZUKI, J., YU, X. M., CHIAN, R. C., HERMO, L., O’FLAHERTY, C., SMITH, C. E., CLARKE, H. J. & WING, S. S. (2011)
Mice Lacking the USP2 Deubiquitinating Enzyme Have Severe Male Subfertility Associated with Defects in Fertilization and Sperm Motility
Biology of Reproduction , 85, 3, 594-604.

WAI, T., AO, A., ZHANG, X., CYR, D., DUFORT, D. & SHOUBRIDGE, E. A. (2010)
The role of mitochondrial DNA copy number in mammalian fertility
Biology of Reproduction , 83, 1, 52-62.

SAHAMBI, S. K., PELLAND, A., COOKE, G. M., SCHRADER, T., TARDIF, R., CHARBONNEAU, M., KRISHNAN, K., HADDAD, S., CYR, D. G. & DEVINE, P. J. (2010)
Oral p-tert-octylphenol exposures induce minimal toxic or estrogenic effects in adult female Sprague-Dawley rats
Journal of Toxicology and Environmental Health. Part A , 73, 9, 607-22.

MÉNARD, L., ESCARNÉ, R., MARCOGLIESE, D. J., CYR, D., FOURNIER, M. & GAGNÉ, F. (2010)
The impacts of urban pollution on the immune system of spottail shiners (Notropis hudsonius) in the St. Lawrence River
Fresenius Environmental Bulletin , 19, 7, 1369-1374.

JONES, S. R. & CYR, D. G. (2010)
Regulation and Characterization of the Atp-Binding Cassette Transporter-B1 in the Epididymis and Epididymal Spermatozoa of the Rat
Toxicological Sciences , [Epub ahead of print].

HERMO, L., PELLETIER, R. M., CYR, D. G. & SMITH, C. E. (2010)
Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 1: background to spermatogenesis, spermatogonia, and spermatocytes
Microscopy Research and Technique , 73, 4, 241-78.

HERMO, L., PELLETIER, R. M., CYR, D. G. & SMITH, C. E. (2010)
Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 2: changes in spermatid organelles associated with development of spermatozoa
Microscopy Research and Technique , 73, 4, 279-319.

HERMO, L., PELLETIER, R. M., CYR, D. G. & SMITH, C. E. (2010)
Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 5: intercellular junctions and contacts between germs cells and Sertoli cells and their regulatory interactions, testicular cholesterol, and genes/proteins associated with more than one germ cell generation
Microscopy Research and Technique , 73, 4, 409-94.

HERMO, L., PELLETIER, R. M., CYR, D. G. & SMITH, C. E. (2010)
Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 4: intercellular bridges, mitochondria, nuclear envelope, apoptosis, ubiquitination, membrane/voltage-gated channels, methylation/acetylation, and transcription factors
Microscopy Research and Technique , 73, 4, 364-408.

HERMO, L., PELLETIER, R. M., CYR, D. G. & SMITH, C. E. (2010)
Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 3: developmental changes in spermatid flagellum and cytoplasmic droplet and interaction of sperm with the zona pellucida and egg plasma membrane
Microscopy Research and Technique , 73, 4, 320-63.

FOSTER, W. G., MAHARAJ-BRICEÑO, S. & CYR, D. G. (2010)
Dioxin-Induced changes in epididymal sperm count and spermatogenesis
Environmental Health Perspectives , 118, 4, 458-464.

DUBÉ, E., HERMO, L., CHAN, P. T. K. & CYR, D. G. (2010)
Alterations in the human blood-epididymis barrier in obstructive azoospermia and the development of novel epididymal cell lines from infertile men
Biology of Reproduction , 83, 4, 584-596.

DUBÉ, É., DUFRESNE, J., CHAN, P. T. K., HERMO, L. & CYR, D. G. (2010)
Assessing the role of claudins in maintaining the integrity of epididymal tight junctions using novel human epididymal cell lines
Biology of Reproduction , 82, 6, 1119-1128.

DE MONTGOLFIER, B., AUDET, C. & CYR, D. G. (2010)
Regulation of the connexin 43 promoter in the brook trout testis: Role of the thyroid hormones and cAMP
General and Comparative Endocrinology , [Epub ahead of print].

CYR, D. G. & NAGLER, J. J. (2010)
Cellular interactions and spermatogenesis in the fish testis . In: GARCIA-AYALA, A., MESEGUER PEÑALVER, J. & CHAVES-POZO, E. (Eds.)
Recent Advances in Fish Reproduction Biology. Kerala, Indes, SignPost Publications, 109-126.

MÜLLER, C., RUBY, S., BROUSSEAU, P., CYR, D., FOURNIER, M. & GAGNE, F. (2009)
Immunotoxicological effects of an activated-sludge-treated effluent on rainbow trout (Oncorhynchus mykiss)
Comparative Biochemistry and Physiology, Part C: Toxicology & Pharmacology , 150C, 3, 390-394.

HÉBERT, N., GAGNÉ, F., CYR, D., PELLERIN, J., BLAISE, C. & FOURNIER, M. (2009)
Effects of 4-nonylphenol on the immune system of rainbow trout (Oncorhynchus mykiss)
Fresenius Environmental Bulletin , 18, 5a, 757-761.

HAMELIN, G., CHAREST-TARDIF, G., KRISHNAN, K., CYR, D., CHARBONNEAU, M., DEVINE, P. J., HADDAD, S., COOKE, G. M., SCHRADER, T. & TARDIF, R. (2009)
Toxicokinetics of p-tert-octylphenol in male and female Sprague-Dawley rats after intravenous, oral, or subcutaneous exposures
Journal of Toxicology and Environmental Health – Part A: Current Issues , 72, 8, 541-550.

GREGORY, M., LACROIX, A., HADDAD, S., DEVINE, P., CHARBONNEAU, M., TARDIF, R., KRISHNAN, K., COOKE, G. M., SCHRADER, T. & CYR, D. G. (2009)
Effects of chronic exposure to octylphenol on the male rat reproductive system
Journal of Toxicology and Environmental Health. Part A , 72, 23, 1553-60.

DE MONTGOLFIER, B., FAYE, A., AUDET, C. & CYR, D. G. (2009)
Seasonal variations in testicular connexin levels and their regulation in the brook trout, Salvelinus fontinalis
General and Comparative Endocrinology , 162, 3, 276-285.

LOPARDO, T., LO IACONO, N., MARINARI, B., GIUSTIZIERI, M. L., CYR, D. G., MERLO, G., CROSTI, F., COSTANZO, A. & GUERRINI, L. (2008)
Claudin-1 is a p63 target gene with a crucial role in epithelial development
PLoS ONE , 3, 7.

KING, K. C., GENDRON, A. D., MCLAUGHLIN, J. D., GIROUX, I., BROUSSEAU, P., CYR, D., RUBY, S. M., FOURNIER, M. & MARCOGLIESE, D. J. (2008)
Short-term seasonal changes in parasite community structure in northern leopard froglets (Rana pipiens) inhabiting agricultural wetlands
Journal of Parasitology , 94, 1, 13-22.

JOSEPHY, P. D. & CYR, D. G. (2008)
Northern Exposures, Northern Risks: Toxicology in Canada
Chemical Research in Toxicology , 21, 10, 1909-1912.

HERMO, L., CHUNG, S., GREGORY, M., SMITH, C. E., SHU, P. W., EL-ALFY, M., CYR, D. G., MITCHELL, G. A. & TRASLER, J. (2008)
Alterations in the testis of hormone sensitive lipase-deficient mice is associated with decreased sperm counts, sperm motility, and fertility
Molecular Reproduction and Development , 75, 4, 565-577.

HÉBERT, N., GAGNÉ, F., CEJKA, P., CYR, D., MARCOGLIESE, D. J., BLAISE, C., PELLERIN, J. & FOURNIER, M. (2008)
The effects of a primary-treated municipal effluent on the immune system of rainbow trout (Oncorhynchus mykiss): Exposure duration and contribution of suspended particles
Comparative Biochemistry and Physiology – C Toxicology and Pharmacology , 148, 3, 258-264.

HÉBERT, N., GAGNÉ, F., CEJKA, P., BOUCHARD, B., HAUSLER, R., CYR, D. G., BLAISE, C. & FOURNIER, M. (2008)
Effects of ozone, ultraviolet and peracetic acid disinfection of a primary-treated municipal effluent on the Immune system of rainbow trout (Oncorhynchus mykiss)
Comparative Biochemistry and Physiology – C Toxicology and Pharmacology , 148, 2, 122-127.

HAMELIN, G., CHAREST-TARDIF, G., KRISHNAN, K., CYR, D. G., CHARBONNEAU, M., DEVINE, P. J., HADDAD, S., COOKE, G. M., SCHRADER, T. & TARDIF, R. (2008)
Determination of p-tert-octylphenol in blood and tissues by gas chromatography coupled with mass spectrometry
Journal of Analytical Toxicology , 32, 4, 303-307.

GREGORY, M., ARAVINDAKSHAN, J., NADZIALEK, S. & CYR, D. G. (2008)
Effects of endocrine disrupting chemicals on testicular functions .
Fish Spermatology. 161-214.

ESCARNÉ, R., GAGNÉ, F., DAUTREMEPUITS, C., CYR, D. G., FINNSON, K., MARCOGLIESE, D. J., BERNIER, J., CEJKA, P. & FOURNIER, M. (2008)
Effects of municipal sewage effluent on non-specific immune and thyroid functions of rainbow trout (Oncorhynchus mykiss)
Trends in Comparative Biochemistry & Physiology , 13, 27-39.

DUBE, E., HERMO, L., CHAN, P. T. K. & CYR, D. G. (2008)
Alterations in gene expression in the caput epididymides of nonobstructive azoospermic men
Biology of Reproduction , 78, 2, 342-351.

DE MONTGOLFIER, B., FOURNIER, M., AUDET, C., MARCOGLIESE, D. J. & CYR, D. G. (2008)
Influence of municipal effluents on the expression of connexins in the brook trout (Salvelinus fontinalis) testis
Aquatic Toxicology , 86, 1, 38-48.

SRIDHARAN, S., SIMON, L., MELING, D. D., CYR, D. G., GULSTEIN, D. E., FISHMAN, G. I., GUILLOU, F. & COOKE, P. S. (2007)
Proliferation of adult sertoli cells following conditional knockout of the gap junctional protein GJA1 (connexin 43) in mice
Biology of Reproduction , 76, 5, 804-812.

SALO, H. M., HÉBERT, N., DAUTREMEPUITS, C., CEJKA, P., CYR, D. G. & FOURNIER, M. (2007)
Effects of Montreal municipal sewage effluents on immune responses of juvenile female rainbow trout (Oncorhynchus mykiss)
Aquatic Toxicology , 84, 4, 406-414.

PRIMIANI, N., GREGORY, M., DUFRESNE, J., SMITH, C. E., YE, L. L., BARTLES, J. R., CYR, D. G. & HERMO, L. (2007)
Microvillar size and espin expression in principal cells of the adult rat epididymis are regulated by androgens
Journal of Andrology , 28, 5, 659-669.

PLANTE, I., CYR, D. G. & CHARBONNEAU, M. (2007)
Sexual dimorphism in the regulation of liver connexin32 transcription in hexachlorobenzene-treated rats
Toxicological Sciences , 96, 1, 47-57.

PLANTE, I., CHARBONNEAU, M. & CYR, D. G. (2007)
Regulation of cell-cell interactions in hexachlorobenzene-induced hepatocarcinogenesis in rat [Régulation des interactions cellule-cellule dans l’hépatocancérogenèse induite par l’hexachlorobenzène chez le rat]
Bulletin de la Societe Zoologique de France , 132, 1-2, 23-30.

PICARD-AITKEN, M., MARCOGLIESE, D. J., PARISEAU, R., FOURNIER, H. & CYR, D. G. (2007)
Iodothyronine deiodinases in fish: Walleye (Sander vitreus), a new model for the study of endocrine disruption [Les déiodinases thyroïdiennes chez les poissons: Le doré jaune (Sander vitreus), un nouveau modèle pour l’étude des modulateurs endocriniens]
Bulletin de la Société zoologique de France , 132, 1-2, 37-44.

PICARD-AITKEN, M., FOURNIER, H., PARISEAU, R., MARCOGLIESE, D. J. & CYR, D. G. (2007)
Thyroid disruption in walleye (Sander vitreus) exposed to environmental contaminants: Cloning and use of iodothyronine deiodinases as molecular biomarkers
Aquatic Toxicology , 83, 3, 200-211.

NAGLER, J. J., CAVILEER, T., SULLIVAN, J., CYR, D. G. & REXROAD, C. (2007)
The complete nuclear estrogen receptor family in the rainbow trout: Discovery of the novel ER alpha 2 and both ER beta isoforms
Gene , 392, 1-2, 164-173.

KISHTA, O., ADEEKO, A., LI, D., LUU, T., BRAWER, J. R., MORALES, C., HERMO, L., ROBAIRE, B., HALES, B. F., BARTHELEMY, J., CYR, D. G. & TRASLER, J. M. (2007)
In utero exposure to tributyltin chloride differentially alters male and female fetal gonad morphology and gene expression profiles in the Sprague-Dawley rat
Reproductive Toxicology , 23, 1, 1-11.

KHATCHADOURIAN, K., SMITH, C. E., METZLER, M., GREGORY, M., HAYDEN, M. R., CYR, D. G. & HERMO, L. (2007)
Structural abnormalities in spermatids together with reduced sperm counts and motility underlie the reproductive defect in HIP1-/- mice
Molecular Reproduction and Development , 74, 3, 341-359.

HERMO, L., KORAH, N., GREGORY, M., LIU, L. Y., CYR, D. G., D’AZZO, A. & SMITH, C. E. (2007)
Structural alterations of epididymal epithelial cells in cathepsin A-deficient mice affect the blood-epididymal barrier and lead to altered sperm motility
Journal of Andrology , 28, 5, 784-797.

DUFRESNE, J. & CYR, D. G. (2007)
Activation of an SP binding site is crucial for the expression of Claudin 1 in rat epididymal principal cells
Biology of Reproduction , 76, 5, 825-832.

DUBÉ, E. & CYR, D. G. (2007)
The blood-epididymal barrier and its role in male fertility [Étude du rôle de la barrière hémato- épididymaire dans le maintien de la fertilité]
Bulletin de la Societe Zoologique de France , 132, 1-2, 31-36.

DUBÉ, E., CHAN, P. T. K., HERMO, L. & CYR, D. G. (2007)
Gene expression profiling and its relevance to the blood-epididymal barrier in the human epididymis
Biology of Reproduction , 76, 6, 1034-1044

DE MONTGOLFIER, B., DUFRESNE, J., LÉTOURNEAU, M., NAGLER, J. J., FOURNIER, A., AUDET, C. & CYR, D. G. (2007)
The expression of multiple connexins throughout spermatogenesis in the rainbow trout testis suggests a role for complex intercellular communication
Biology of Reproduction , 76, 1, 2-8.

CYR, D. G., GREGORY, M., DUBÉ, E., DUFRESNE, J., CHAN, P. T. K. & HERMO, L. (2007)
Orchestration of occludins, claudins, catenins and cadherins as players involved in maintenance of the blood-epididymal barrier in animals and humans
Asian Journal of Andrology , 9, 4, 463-475.

BROUSSEAU, P., MÉNARD, L., ARAVINDAKSHAN, J. P., GREGORY, M., MARCOGLIESE, D., CYR, D. G. & FOURNIER, M. (2007)
Effects of a diet prepared with fish captured upstream and downstream of a wastewater treatment plant, releasing xenoestrogens, on post-natal development of immune system in male rats exposed only by lactation [Effets d’une diète de poissons provenant d’un milieu contaminé par des xénŒstrogènes sur le développement post-natal du système immunitaire de rats mâles]
Bulletin de la Societe Zoologique de France , 132, 1-2, 147-158.

BARTHELEMY, J., ADEEKO, A., ROBAIRE, B. & CYR, D. G. (2007)
In utero exposure to tributyltin alters the expression of E-cadherin and localization of claudin-1 in intercellular junctions of the rat ventral prostate
Molecular Reproduction and Development , 74, 4, 455-467.

RUZ, R., GREGORY, M., SMITH, C. E., CYR, D. G., LUBAHN, D. B., HESS, R. A. & HERMO, L. (2006)
Expression of aquaporins in the efferent ductules, sperm counts, and sperm motility in estrogen receptor-alpha deficient mice fed lab chow versus casein
Molecular Reproduction and Development , 73, 2, 226-237.

PLANTE, I., CHARBONNEAU, M. & CYR, D. G. (2006)
Activation of the integrin-linked kinase pathway downregulates hepatic connexin32 via nuclear Akt
Carcinogenesis , 27, 9, 1923-1929.

PILLET, S., D’ELIA, M., BERNIER, J., BOUQUEGNEAU, J. M., FOURNIER, M. & CYR, D. G. (2006)
Immunomodulatory effects of estradiol and cadmium in adult female rats
Toxicological Sciences , 92, 2, 423-432.

MARCOGLIESE, D. J., GENDRON, A. D., PLANTE, C., FOURNIER, M. & CYR, D. (2006)
Parasites of spottail shiners (Notropis hudsonius) in the St. Lawrence River: Effects of municipal effluents and habitat
Canadian Journal of Zoology , 84, 10, 1461-1481.

GREGORY, M. & CYR, D. G. (2006)
Identification of multiple claudins in the rat epididymis
Molecular Reproduction and Development , 73, 5, 580-588.

PLANTE, I., CYR, D. G. & CHARBONNEAU, M. (2005)
Involvement of the integrin-linked Kinase pathway in hexachlorobenzene-induced gender-specific rat hepatocarcinogenesis
Toxicological Sciences , 88, 2, 346-357.

PILLET, S., ROONEY, A. A., BOUQUEGNEAU, J. M., CYR, D. G. & FOURNIER, M. (2005)
Sex-specific effects of neonatal exposures to low levels of cadmium through maternal milk on development and immune functions of juvenile and adult rats
Toxicology , 209, 3, 289-301.

HADDAD, S., D’ELIA, M., BERNIER, J., FOURNIER, A. & CYR, D. G. (2005)
Applications of genomics in immunotoxicology
Investigative Immunotoxicology , 363-385.

GROVER, A., SMITH, C. E., GREGORY, M., CYR, D. G., SAIRAM, M. R. & HERMO, L. (2005)
Effects of FSH receptor deletion on epididymal tubules and sperm morphology, numbers, and motility
Molecular Reproduction and Development , 72, 2, 135-144.

DUFRESNE, J., ST-PIERRE, N., VIGER, R. S., HERMO, L. & CYR, D. G. (2005)
Characterization of a novel rat epididymal cell line to study epididymal function
Endocrinology , 146, 11, 4710-4720.

BEDARD, N., HINGAMP, P., PANG, Z., KARAPLIS, A., MORALES, C., TRASLER, J., CYR, D., GAGNON, C. & WING, S. S. (2005)
Mice lacking the UBC4-testis gene have a delay in postnatal testis development but normal spermatogenesis and fertility
Molecular and Cellular Biology , 25, 15, 6346-54.

ARAVINDAKSHAN, J. & CYR, D. G. (2005)
Nonylphenol alters connexin 43 levels and connexin 43 phosphorylation via an inhibition of the p38-mitogen-activated protein kinase pathway
Biology of Reproduction , 72, 5, 1232-1240.

CYR, D. G., PILLET, S. & NICOLAS, J. M. (2004)
Interactions cellule-cellule: cible des contaminants environnementaux. .
Écotoxicologie Moléculaire: Principes fondamentaux et perspectives de développement., Presse de l’Univ Québec, Québec, 301-348.

CHRISTIN, M. S., MÉNARD, L., GENDRON, A. D., RUBY, S., CYR, D., MARCOGLIESE, D. J., ROLLINS-SMITH, L. & FOURNIER, M. (2004)
Effects of agricultural pesticides on the immune system of Xenopus laevis and Rana pipiens
Aquatic Toxicology , 67, 1, 33-43.

BROWN, S. B., ADAMS, B. A., CYR, D. G. & EALES, J. G. (2004)
Contaminant effects on the teleost fish thyroid
Environmental Toxicology and Chemistry , 23, 7, 1680-1701.

ARAVINDAKSHAN, J., PAQUET, V., GREGORY, M., DUFRESNE, J., FOURNIER, M., MACROGLIESE, D. J. & CYR, D. G. (2004)
Consequences of xenoestrogen exposure on male reproductive function in spottail shiners (Notropis hudsonius)
Toxicological Sciences , 78, 1, 156-165.

ARAVINDAKSHAN, J., GREGORY, M., MARCOGLIESE, D. J., FOURNIER, M. & CYR, D. G. (2004)
Consumption of xenoestrogen-contaminated fish during lactation alters adult male reproductive function
Toxicological Sciences , 81, 1, 179-189.