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Charles Calmettes

Looking for students or interns

Areas of expertise

Biochemistry , Structural biology, Nanobiology

  • Associate Professor

450-687-5010, extension 8885


Armand-Frappier Santé Biotechnologie Research Centre

531, boulevard des Prairies
Laval (Québec)  H7V 1B7

See the research centre

– 2019 

17. El Bakkouri MKouidmi I, Wernimont A, Amani M, Hutchinson A, Loppnau P, Kim J, Flueck C, Walker J, Seitova A, Senisterra G, Kakihara Y, Kim C, Blackwell M, Calmettes C, Baker DA, Hui R (2019) Structures of Plasmodium PKG reveal a unique relay mechanism for allosteric and cooperativity. PNAS 10.1073/pnas.1905558116

16. Fegan JE, Calmettes C, Islam EA, Ahn SK, Chaudhuri S, Yu RH, Gray-Owen SD, Moraes TF, Schryvers AB (2019) Utility of Hybrid Transferrin Binding Protein Antigens for Protection Against Pathogenic Neisseria Species. Frontiers in Immunology 10.3389/fimmu.2019.00247

– 2018 

15. Babu M*, Bundalovic-Torma C*, Calmettes C*, Phanse S, Jiang Y, Deineko V, Mehla J, Vastermark A, Kagan O, Pogoutse O, Gagarinova A, Kumar A, Guo H, Minic Z, Aoki H, Holtzapple E, Zhang Z, Pandya Y, Lai CCL, Leung E, El Bakkouri M, Hooda Y, Shah M, Vlasblom J, Greenblatt JF, Rajagopala SV, Wutchy S, Houry W, Saier M, Uetz P, Moraes TF, Parkinson J, Emili A (2017) Global landscape of membrane protein complexes in Escherichia coli. Nature Biotechnology 10.1038/nbt.4024 (* equal contribution)

– 2017

14. Pawluk A, Shah M., Mejdani M, Calmettes C, Moraes TF, Davidson A, Maxwell K (2017) Disabling a type I-E CRISPR-Cas nuclease with a bacteriophage-encoded anti-CRISPR protein. mBio, 10.1128/mBio.01751-17

– 2016

13. McCallum M, Tammam S, Little DJ, Robinson H, Koo J, Shah M, Calmettes C, Moraes TF, Burrows LL, Howell PL (2016) PilN Binding Modulates the Structure and Binding Partners of the Pseudomonas aeruginosa Type IVa Pilus Protein PilM. J Biol Chem. 291:11003-15


12. Calmettes C, Judd A, Moraes TF (2015) Structural Aspects of Bacterial Outer Membrane Protein Assembly. Adv Exp Med Biol. 883:255-70

11. Sit B, Crowley SM, Bhullar K, Lai CC, Tang C, Hooda Y, Calmettes C, Khambati H, Ma C, Brumell JH, Schryvers AB, Vallance BA, Moraes TF (2015) Active Transport of Phosphorylated Carbohydrates Promotes Intestinal Colonization and Transmission of a Bacterial Pathogen. Plos Pathog. 11:e1005107

10. Calmettes C, Ing C, Buckwalter CM, El Bakkouri M, Chieh-Lin Lai C, Pogoutse A, Gray-Owen SD, Pomès R, Moraes TF (2015) The molecular mechanism of Zinc acquisition by the neisserial outer-membrane transporter ZnuD. Nature Communications 6:7996

09. Adamiak P*, Calmettes C*, Moraes TF, Schryvers AB (2015) Patterns of structural and sequence variation within isotype lineages of the Neisseria meningitidis transferrin receptor system. Microbiologyopen 4:491-504 (* equal contribution)

08. Frandoloso R*, Martínez-Martínez S*, Calmettes C*, Fegan J, Costa E, Curran D, Yu RH, Gutiérrez-Martín CB, Rodríguez-Ferri EF, Moraes TF, Schryvers AB (2015) Nonbinding site-directed mutants of transferrin binding protein B exhibit enhanced immunogenicity and protective capabilities. Infect Immun. 83:1030-8 (* equal contribution)


07. Shnitsar V, Li J, Li X, Calmettes C, Basu A, Casey JR, Moraes TF, Reithmeier RA (2013) A substrate access tunnel in the cytosolic domain is not an essential feature of the solute carrier 4 (SLC4) family of bicarbonate transporters. J Biol Chem. 288:33848-60

06. El Bakkouri M, Rathore S, Calmettes C, Wernimont AK, Liu K, Sinha D, Asad M, Jung P, Hui R, Mohmmed A, Houry WA (2013) Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum. J Biol Chem. 288:1022-31


05. Silva LP, Yu RH, Calmettes C, Yang X, Moraes TF, Schriemer DC, Schryvers AB (2012) Steric and allosteric factors prevent simultaneous binding of transferrin-binding proteins A and B to transferrin. Biochem J. 444:189-97

04. Calmettes C, Alcantara J, Yu RH, Schryvers AB, Moraes TF (2012) The structural basis of transferrin sequestration by transferrin-binding protein B. Nature Stuctural & Molecular Biology. 19:358-60


03. Yang X, Yu RH, Calmettes C, Moraes TF, Schryvers AB (2011) Anchor peptide of transferrin-binding protein B is required for interaction with transferrin-binding protein A. J Biol Chem. 286:45165-73

02. Silva LP, Yu R, Calmettes C, Yang X, Moraes TF, Schryvers AB, Schriemer DC (2011) Conserved interaction between transferrin and transferrin-binding proteins from porcine pathogens. J Biol Chem. 286:21353-60

01. Calmettes C, Yu RH, Silva LP, Curran D, Schriemer DC, Schryvers AB, Moraes TF (2011) Structural variations within the transferrin binding site on transferrin-binding protein B, TbpB. J Biol Chem. 286:12683-92