Christiane Ayotte

Areas of expertise

Doping control

Phone
450-686-5442

Fax
450-686-5614

E-mail
christiane.ayotte@iaf.inrs.ca

Armand-Frappier Santé Biotechnologie Research Centre

531, boulevard des Prairies
Laval (Québec)  H7V 1B7
Canada

See research centre

Interested research topics

Pr. Ayotte obtained her M.Sc. (1978) and Ph.D. (1983) degrees in Organic Chemistry (Photochemistry) from the Université de Montréal. Following two years of postdoctoral studies in mass spectrometry at the “INRS-Santé”, she joined as a research associate its Doping Control Laboratory.

Her main research interests were then the characterization of the urinary metabolites of anabolic steroids and this lead to the development of a comprehensive gas chromatographic/mass spectrometric method for the detection and identification of anabolic agents.

She is responsible for the Doping Control Laboratory since 1991 and was research associate professor since 1992. She is a member of the IAAF doping Commission since 1995, of the IOC Working Group on Harmonization of Laboratory protocols (1996-…) and was elected representative of the Heads of IOC Accredited Laboratories in 1995-1996.

She is often requested to act as an expert for sport administrative, civil or criminal court hearings and arbitration in Canada, USA and Europe.

Pr. Ayotte obtained her M.Sc. (1978) and Ph.D. (1983) degrees in Organic Chemistry (Photochemistry) from the Université de Montréal. Following two years of postdoctoral studies in mass spectrometry at the “INRS-Santé”, she joined as a research associate its Doping Control Laboratory. Her main research interests were then the characterization of the urinary metabolites of anabolic steroids and this lead to the development of a comprehensive gas chromatographic/mass spectrometric method for the detection and identification of anabolic agents.She is responsible for the Doping Control Laboratory since 1991 and was research associate professor since 1992. She is a member of the IAAF doping Commission since 1995, of the IOC Working Group on Harmonization of Laboratory protocols (1996-…) and was elected representative of the Heads of IOC Accredited Laboratories in 1995-1996. She is often requested to act as an expert for sport administrative, civil or criminal court hearings and arbitration in Canada, USA and Europe.

Publications

Publications

Gauthier J, Goudreault D, Poirier D, Ayotte C. Identification of drostanolone and 17-methyldrostanolone metabolites produced by cryopreserved human hepatocytes.  Steroids. 2008 Nov 13. [Epub ahead of print]

Guay C, Goudreault D, Schänzer W, Flenker U, Ayotte C.  Excretion of norsteroids’ phase II metabolites of different origin in human. Steroids. 2008 Nov 5. [Epub ahead of print]

Groleau PE, Desharnais P, Coté L, Ayotte C. Low LC-MS/MS detection of glycopeptides released from pmol levels of recombinant erythropoietin using nanoflow HPLC-chip electrospray ionization. J Mass Spectrom. 2008 Jul;43(7):924-35.

Kohler, M., Ayotte C., Desharnais P., Flenker, U., Ludke, S., Thevis, M., Folker-Schanzer, E., et Schanzer, W., Discrimination of recombinant and endogenous urinary erythropoietin by calculating relative mobility values from SDS Gels, Int. J. Sports Med., 2007.

Hebestreit M, Flenker U, FuBhöller G., Geyer H, Güntner U, Mareck U, Piper T, Thevis M., Ayotte, C. and Schänzer W. Determination of the Origin of Urinary Norandrosterone Traces by Gas Chromatography Combustion Isotope Ratio Mass Spectrometry.  Analyst, 2006, 131 1021-1026.

AYOTTE, C.: The significance of 19-norandrosterone findings in athletes’ urine samples, (review), Br J Sport Med 2006; 40 (Suppl.): i25-i29.

AYOTTE, C.: Suivi des profils de stéroïdes urinaires dans le contrôle du dopage des sportifs, Revue francophone des laboratoires, no. 401 (avril 2008), 39-46.

Pipe, A., and C. Ayotte (2002) Nutritional supplements and doping. Clin. J. Sport Med. 12(4):245-249.

Ayotte, C., J.F. Lévesque, M. Cléroux, A. Lajeunesse, D. Goudreault, and A. Fakirian (2001) Sport nutritional supplements: quality and doping controls.Can.J. Appl. Physiol. 26 Suppl: S120-9.

Robinson, N., F. Taroni, M. Saugy, C. Ayotte, P. Mangin, and J. Dvorak (2001) Detection of nandrolone metabolites in urine after a football game in professional and amateur players: a Bayesian comparison.Forensic. Sci. Int. 122(2-3): 130-135.

Ayotte, C., and D. Goudreault (1999) The detection of new synthetic drugs in athletes’ urine samples.

Journal of Toxicology, Toxin Reviews, Special Issue on Doping in Sports: Current Issues, 18 (2): 113-123.

Ayotte, C. (1999) Nutritional supplements and doping controls IAF New Studies in Athletics, 14, 37. (PDF)

Ayotte, C. (1998) Doping: Different conditions. Concerns and Dangers forWomen, Official proceedings, IAF International Seminar, From a Great Past toan Even Brighter Future Women’s Athletics on the Eve of the New Millennium Granada, p.47

Brisson, G.R., A. Guttierez Sainz, C. Ayotte, R. Gareau, L. Senecal, and M.J.Castillo (1997) Influence of a transscrotal testosterone propionate administration on the serum level of selected hormones of the hypophyso-gonadal axis.J. Steroid Biochem. Mol. Biol. 62(1): 65-71.

Brisson, G.R., A. Guttierez Sainz, C. Ayotte, R. Gareau, L. Senecal, M.J. Castillo (1997) Frequent serum sampling in healthy men discloses testosterone peaks exacerbated by testosterone propionate administration.Can.J. Appl. Physiol. 22(1): 58-65.

Ayotte, C. (1997) Evaluation of elevated testosterone/epitestosterone values inathletes’ urine samples IAF New Studies in Athletics, 13 (2/3), 87.

Ayotte, C., D. Goudreault, and A.Charlebois (1996) Testing for natural and synthetic an abolic agents in human urine. J. Chromatogr. B Biomed. Appl. 87(1): 3-25.

Chapitres de livres

Christiane Ayotte, Testing for Anabolic Agents Pharmacology, Doping and Sport: A Complete Guide for Athletes, Coaches, Physicians, Scientists and Administrators, Taylor and Francis publ., Jean Fourcroy ed, (2008) Chap 4, p.37-54

Compte rendus

AYOTTE, C., GUAY, C., CLÉROUX, M., GOUDREAULT, D. and FAKIRIAN, A. Origin of elevated levels of norandrosterone in human urine:  half-truths vs. facts Recent advances in doping analysis (10), Proceedings of the 20th Cologne Workshop on Dope analysis, Schanzer W. Geyer H., Gotzmann A., and Mareck-Engelke U. (eds). Sport & Buch Straub Cologne, (2002), p. 13.

AYOTTE, C. Litigation and Doping Controls: Defending positive findings of endogenous steroids

Recent Advances in Doping Analysis (10), Proceedings of the 21th Cologne Workshop on Dope Analysis, W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck-Engelke (editors) Sport and Buch Straub, Köln (2003) p. 239.

AYOTTE, C., GOUDREAULT, D., CYR, D., GAUTHIER, J., AYOTTE, P., C. LAROCHELLE and POIRIER, D.

Characterisation of chemical and hormonal properties of new steroids related to doping of athletes

Proceedings of the Manfred Donike Workshop, 24th Cologne Workshop on Dope Analysis, Cologne, June 2006, p. 151.

AYOTTE, C., ROMIGUIÈRE, C., FAKIRIAN, A., FLENKER, U., HEBESTREIT, M., PIPER, T. and SCHANZER, W.

The usefulness of GC/C/IRMS in determining the origin of low levels 19-NA: Application to routine analyses

Proceedings of the Manfred Donike Workshop, 24th Cologne Workshop on Dope Analysis, Cologne, June 2006, p. 277.

P. Desharnais, P.E. Groleau, C. Hamelin, and C. Ayotte Intermediate neuraminidase activity: a possible link toward suspicious or “effort-like” EPO isoelectric profiles Proceedings of the Manfred Donike Workshop, 24th Cologne Workshop on Dope Analysis, Cologne, June 2006, p. 435.

P.E. Groleau, P. Desharnais,  C. Hamelin, and C. Ayotte Purification of EPO from urine retentates prior to IEF

Proceedings of the Manfred Donike Workshop, 24th Cologne Workshop on Dope Analysis, Cologne, June 2006, p. 431.

C. AYOTTE Steroid profiling in anti-doping controls Proceedings of the 5th Annual USADA Symposium on Anti-Doping Science: “Intra-Individual Reference Ranges:  Implications for Doping Control”, Lausanne 2006.

C. AYOTTE Current Anti-Doping Realities.  Specific Scientific Issues: Anabolic Androgenic Steroids

Book of Proceedings of the 2006 IAAF World Anti-Doping Symposium, Effectiveness of the Anti-Doping Fight, Lausanne 2006.