Yves St-Pierre

Professeur INRS

Training openings for students or interns

Areas of expertise

Breast cancer , Cancer and metastases , Galectin MMP , Galectins , Haematological cancers

  • INRS Professor

Phone
450 686-5354

Fax
450 686-5501

E-mail
yves.st-pierre@iaf.inrs.ca

Armand-Frappier Santé Biotechnologie Research Centre

531, boulevard des Prairies
Laval (Québec)  H7V 1B7
CANADA

See research centre

Interested research topics

The roles of galectins in cancer.

Our research focuses on the role of galectins in cancer. Galectins represent a family of evolutionarily conserved animal lectins that are widely distributed from lower invertebrates to higher vertebrates. They were initially described in 1975 in the electric eel, Electrophorus electricus, as low molecular weight, β-galactoside binding proteins. Since then, galectins have been numbered according to the order of their discovery. The 15 family members are now classified according to their structure and number of carbohydrate recognition domains (CRDs). The prototype subfamily of galectins (galectin-1, -2, -5, -7, -10, -11, -13, -14, and -15) consists of a single CRD with a short N-terminal sequence. In this subfamily, the CRD exists as a monomer that noncovalently dimerizes in solution. The tandem-repeat type subfamily members (galectin-4, -6, -8, -9, and -12) are constitutively bivalent since their gene encodes one single protein displaying two non-identical CRDs joined by a short linker peptide sequence. There is also a chimeric form of galectin (galectin-3) that contains one CRD connected to a non-lectin domain, which helps in the formation of multimers that form disorganized heterogeneous cross-linked complexes. Sequencing of galectins isolated from amphibians, birds, fish, and mammals has revealed extensive sequence similarity. In addition to the presence of a CRD, all galectins harbour a highly conserved three-dimensional structure characterized by a jelly-roll topology composed of an 11- or 12-strand anti-parallel b-sandwich of approximately 135-140 amino acid residues. The main structural differences among galectins are located in the loop regions, which contain the main flexible areas of galectins. These structural differences between galectins are believed to be responsible for variations in their carbohydrate ligand specificity and their divergent function.

It is now well established that galectins are expressed at abnormally high levels in both tumour cells and peritumoral cells. Once released in the extracellular space, galectins binds to repeating units of high density O-glycans on the peptide backbone of membrane receptors, facilitating the packing of glycosylated receptors into an ordered cross-linked lattice at the cell surface. Such cross-linking of glycosylated receptors triggers cell death or activation of other signals that regulate cell fate. On immune cells, this cascade of events has been shown to regulate both innate and acquired immune responses by killing immune cells, helping tumors escape the anti-tumoral immune response. Overexpression of galectins by cancer cells thus contributes to local and systemic immunosuppression in cancer patients. Another means by which prototypic galectins contribute to cancer is via their binding to cell surface glycoreceptors expressed on cancer cells, protecting them from negative regulation via constitutive endocytosis. By doing so, sensitivity of tumour cells to growth factors is increased, promoting growth of cancer cells. Binding of galectins on cancer cells will also promote their invasive behavior by increasing cell motility and/or by metastatic genes, such as mmp-9.

Most studies on galectins have focused on galectin-1 and -3. Our lab got interested on galectin-7 many years ago while comparing the transcriptome of highly metastatic and non-metastatic cancer cells. We were among the first research group to show that galectin-7 plays a central role in promoting cancer progression, at least for certain types of cancer, such as lymphoma, triple-negative breast cancer and high grade serous ovarian carcinoma. We are now exploring novel means by which we could inhibit the protumorigenic activity of galecitn-7. We are also exploring the relevance of less well known galectins in cancer, such as galectin-8, galectin-14 and others. We use in vitro cell models combined to genetic engineering to understand how they work. We are also using tissue microarrays constructed from tumour samples of patients with aggressive forms of cancer, most notably patients with high fatality cancers for which there is no effective treatments.

 

The development of biomarkers for monitoring climate change.

In recent years, our team has used its expertise in molecular immunology and in the development of biomarkers in humans to develop new molecular biomarkers to monitor the medium and long-term impacts of climate change and pollution on aquatic environments. For this purpose, we study cells of the immune system (hemocytes) of the blue mussel, an ideal sentinel species for studying the quality of marine environments. Our team is also interested in studying the role of galectins found in invertebrates (such as the blue mussels) to better understand how the functions of these proteins have developed through evolution. These activities are taking place in collaboration with Dr. Stéphane Betoulle (University of Reims) and the Institut Polaire Paul-Émile Victor (IPEV).

Dr. Yves St-Pierre obtained his B.Sc in Biology from the Université of Québec at Montréal in 1985, and his M.Sc. in Virology from the Institut Armand-Frappier in 1987.  He obtained his Ph.D. in Immunology from the University of Toronto, in 1991. He has completed his postdoctoral training in the Department of Pathology at Harvard University. He is currently Professor at INRS-Institut Armand-Frappier. Dr. St-Pierre is interested in the role of the galectins and extracellular proteases in cancer and inflammatory disorders.

Publications

DUBE-DELAROSBIL, C. & ST-PIERRE, Y. (2018)
The emerging role of galectins in high-fatality cancers,
Cellular and Molecular Life Sciences,
75, 7, 1215-1226z

 

BIBENS-LAULAN, N. & ST-PIERRE, Y. (2017)
Intracellular galectin-7 expression in cancer cells results from an autocrine transcriptional mechanism and endocytosis of extracellular galectin-7,
PloS One, 12, 11,  e0187194-1-13

 

EL-HAWIET, A., CHEN, Y., SHAMS-UD-DOHA, K., KITOVA, E. N., ST-PIERRE, Y. & KLASSEN, J. S. (2017)
High-Throughput Label- and Immobilization-Free Screening of Human Milk Oligosaccharides Against Lectins,
Analytical Chemistry, 89, 17,  8713-8722

 

LABRIE, M., DE ARAUJO, L. O. F., COMMUNAL, L., MES-MASSON, A. M. & ST-PIERRE, Y. (2017)
Tissue and plasma levels of galectins in patients with high grade serous ovarian carcinoma as new predictive biomarkers, Scientific Reports, 7, 1,  13244-1-13

 

SHAMS-UD-DOHA, K., KITOVA, E. N., KITOV, P. I., ST-PIERRE, Y. & KLASSEN, J. S. (2017)
Human Milk Oligosaccharide Specificities of Human Galectins. Comparison of Electrospray Ionization Mass Spectrometry and Glycan Microarray Screening Results, Analytical Chemistry, 89, 9,  4914-4921

 

WILLIAMS, V., GROSSET, A. A., ZAMORANO CUERVO, N., ST-PIERRE, Y., SYLVESTRE, M. P., GABOURY, L. & GRANDVAUX, N. (2017)
Detection of IKK
ε by immunohistochemistry in primary breast cancer: Association with EGFR expression and absence of lymph node metastasis,
BMC Cancer, 17, 1,

 

GROSSET, A. A., POIRIER, F., GABOURY, L. & ST-PIERRE, Y. (2016)
Galectin-7 Expression Potentiates HER-2-Positive Phenotype in Breast Cancer,
PloS One, 11, 11,
e0166731-1-12

 

GROSSET, A. A., LABRIE, M., VLADOIU, M. C., YOUSEF, E. M., GABOURY, L. & ST-PIERRE, Y. (2016)
Galectin signatures contribute to the heterogeneity of breast cancer and provide new prognostic information and therapeutic targets
Oncotarget, 7, 14,  18183-18203

 

VLADOIU, M. C., LABRIE, M., LÉTOURNEAU, M., EGESBORG, P., GAGNE, D., BILLARD, E., GROSSET, A. A., DOUCET, N., CHATENET, D. & ST-PIERRE, Y. (2015)
Design of a peptidic inhibitor that targets the dimer interface of a prototypic galectin
Oncotarget,6, 38,  40970-40980

 

CAZA, F., BETOULLE, S., AUFFRET, M., BROUSSEAU, P., FOURNIER, M. & ST-PIERRE, Y. (2015)
Comparative analysis of hemocyte properties from Mytilus edulis desolationis and Aulacomya ater in the Kerguelen Islands,
Marine Environmental Research, 110, 174-82

 

LABRIE, M., VLADOIU, M., LECLERC, B. G., GROSSET, A. A., GABOURY, L., STAGG, J. & ST-PIERRE, Y. (2015)
A Mutation in the Carbohydrate Recognition Domain Drives a Phenotypic Switch in the Role of Galectin-7 in Prostate Cancer,
PLoS ONE, 10, 7, e0131307

 

GROSSET, A. A., LABRIE, M., GAGNE, D., VLADOIU, M. C., GABOURY, L., DOUCET, N. & ST-PIERRE, Y. (2014)
Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells,
BMC Cancer, 14, 801

 

LABRIE, M., VLADOIU, M. C., GROSSET, A. A., GABOURY, L. & ST-PIERRE, Y. (2014)
Expression and functions of galectin-7 in ovarian cancer
Oncotarget, 5, 17, 7705-7721

 

YOUSEF, E. M., TAHIR, M. R., ST-PIERRE, Y. & GABOURY, L. A. (2014)
MMP-9 expression varies according to molecular subtypes of breast cancer,
BMC Cancer, 14, 609

 

CAMPION, C. G., LABRIE, M., GROSSET, A. A. & ST-PIERRE, Y. (2014)
The CCAAT/Enhancer-Binding Protein Beta-2 Isoform (CEBPbeta-2) Upregulates Galectin-7 Expression in Human Breast Cancer Cells,
PLoS ONE, 9, 5, e95087

 

VLADOIU, M. C., LABRIE, M. & ST-PIERRE, Y. (2014)
Intracellular galectins in cancer cells: Potential new targets for therapy (Review),
International Journal of Oncology, 44, 4, 1001-14

 

KABRO, A., LACHANCE, H., MARCOUX-ARCHAMBAULT, I., PERRIER, V., DORÉ, V., GROS, C., MASSON, V., GREGOIRE, J. M., AUSSEIL, F., CHEISHVILI, D., LAULAN, N. B., ST-PIERRE, Y., SZYF, M., ARIMONDO, P. B. & GAGNON, A. (2013)
Preparation of phenylethylbenzamide derivatives as modulators of DNMT3 activity,
MedChemComm, 4, 12, 1562-1570

 

LABRIE, M. & ST-PIERRE, Y. (2013)
Epigenetic regulation of mmp-9 gene expression,
Cellular and Molecular Life Sciences, 70, 17, 3109-3124

 

CAMPION, C. G., LABRIE, M., LAVOIE, G. & ST-PIERRE, Y. (2013)
Expression of Galectin-7 Is Induced in Breast Cancer Cells by Mutant p53,
PLoS ONE, 8, 8, e72468

 

BIRON-PAIN, K., GROSSET, A. A., POIRIER, F., GABOURY, L. & ST-PIERRE, Y. (2013)
Expression and functions of galectin-7 in human and murine melanomas,
PLoS ONE, 8, 5, e63307

 

ST-PIERRE, Y., CAMPION, C. G. & GROSSET, A.-A. (2012)
A distinctive role for galectin-7 in cancer?
Frontiers in Bioscience , 17, 2, 438-450

 

BIRON-PAIN, K. & ST-PIERRE, Y. (2012)
Monitoring mmp-9 gene expression in stromal cells using a novel transgenic mouse model
Cellular and Molecular Life Sciences , 69, 5, 783-791

 

ST-PIERRE, Y. (2011)
Galectins in hematological malignancies
American Journal of Blood Research. , 1, 2, 119-129

 

RIVARD, M., LALIBERTÉ, M., BERTRAND-GRENIER, A., HARNAGEA, C., PFEFFER, C. P., VALLIÈRES, M., ST-PIERRE, Y., PIGNOLET, A., EL KHAKANI, M. A. & LÉGARÉ, F. (2011)
The structural origin of second harmonic generation in fascia
Biomedical Optics Express , 2, 1, 26-36

 

LAVOIE, G. & ST-PIERRE, Y. (2011)
Phosphorylation of human DNMT1: Implication of cyclin-dependent kinases
Biochemical and Biophysical Research Communications , 409, 2, 187-92

 

LAVOIE, G., ESTÈVE, P.-O., LAULAN, N. B., PRADHAN, S. & ST-PIERRE, Y. (2011)
PKC isoforms interact with and phosphorylate DNMT1
BMC Biology , 9, 1, 31

 

DESPARS, G. & ST-PIERRE, Y. (2011)
Bidirectional interactions between bone metabolism and hematopoiesis
Experimental Hematology , 39, 8, 809-16

 

COUILLARD, J., ESTEVE, P.-O., PRADHAN, S. & ST-PIERRE, Y. (2011)
5-Aza-2′-deoxycytidine and interleukin-1 cooperate to regulate matrix metalloproteinase-3 gene expression
International Journal of Cancer , 129, 9, 2083-2092

 

BIRON-PAIN, K. & ST-PIERRE, Y. (2011)
Monitoring mmp-9 gene expression in stromal cells using a novel transgenic mouse model
Cellular and Molecular Life Sciences , [Epub ahead of print]

 

ROSE, A. A., GROSSET, A. A., DONG, Z., RUSSO, C., MACDONALD, P. A., BERTOS, N. R., ST-PIERRE, Y., SIMANTOV, R., HALLETT, M., PARK, M., GABOURY, L. & SIEGEL, P. M. (2010)
Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer
Clinical Cancer Research , 16, 7, 2147-56

 

EL-ZEIN, M., PARENT, M. E., KA, K., SIEMIATYCKI, J., ST-PIERRE, Y. & ROUSSEAU, M. C. (2010)
History of asthma or eczema and cancer risk among men: a population-based case-control study in Montreal, Quebec, Canada
Annals of Allergy, Asthma, and Immunology , 104, 5, 378-84

 

DEMERS, M., ROSE, A. A. N., GROSSET, A. A., BIRON-PAIN, K., GABOURY, L., SIEGEL, P. M. & ST-PIERRE, Y. (2010)
Overexpression of galectin-7, a myoepithelial cell marker, enhances spontaneous metastasis of breast cancer cells
American Journal of Pathology , 176, 6, 3023-3031

 

BOUCHARD, F., BÉLANGER, S. D., BIRON-PAIN, K. & ST-PIERRE, Y. (2010)
EGR-1 activation by EGF inhibits MMP-9 expression and lymphoma growth
Blood , 116, 5, 759-66

 

AUBÉ, C., BÉLANGER SIMON, D. & ST-PIERRE, Y. (2010)
Lymphoma cells contribute to the augmentation of plasma sL-selectins in the serum of lymphoma-bearing mice Leukemia and Lymphoma , 51, 1, 125-31

 

ST-PIERRE, Y., BIRON-PAIN, K., CAMPION, C., LAVOIE, G., BOUCHARD, F. & COUILLARD, J. (2009)
Potential directions for drug development against galectin-7 in cancer
Expert Opinion on Drug Discovery , 4, 6, 611-620

 

DEMERS, M., COUILLARD, J., GIGLIA-MARI, G., MAGNALDO, T. & ST-PIERRE, Y. (2009)
Increased galectin-7 gene expression in lymphoma cells is under the control of DNA methylation
Biochemical and Biophysical Research Communications , 387, 3, 425-429

 

ROUSSEAU, M. C., PARENT, M. É. & ST-PIERRE, Y. (2008)
Potential health effects from non-specific stimulation of the immune function in early age: The example of BCG vaccination
Pediatric Allergy and Immunology , 19, 5, 438-448

 

ST-PIERRE, Y. (2007)
Drug discovery using the regulation of gene expression
Expert Opinion on Drug Discovery , 2, 7, 987-1000

 

ROY, J. S., VAN THEMSCHE, C., DEMERS, M., OPDENAKKER, G., ARNOLD, B. & ST-PIERRE, Y. (2007)
Triggering of T-cell leukemia and dissemination of T-cell lymphoma in MMP-9-deficient mice
Leukemia , 21, 12, 2506-2511

 

KILANI, R. T., MAKSYMOWYCH, W. P., AITKEN, A., BOIRE, G., ST-PIERRE, Y., LI, Y. & GHAHARY, A. (2007)
Detection of high levels of 2 specific isoforms of 14-3-3 proteins in synovial fluid from patients with joint inflammation
Journal of Rheumatology , 34, 8, 1650-1657

 

KATO, Y., OZAWA, S., TSUKUDA, M., KUBOTA, E., MIYAZAKI, K., ST-PIERRE, Y. & HATA, R. I. (2007)
Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma
ebs Journal , 274, 12, 3171-3183

 

DEMERS, M., BIRON-PAIN, K., HÉBERT, J., LAMARRE, A., MAGNALDO, T. & ST-PIERRE, Y. (2007)
Galectin-7 in lymphoma: Elevated expression in human lymphoid malignancies and decreased lymphoma dissemination by antisense strategies in experimental model
Cancer Research , 67, 6, 2824-2829

 

SIMARD, N., BOIRE, G., DE BRUM-FERNANDES, A. J. & ST-PIERRE, Y. (2006)
A novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis
Arthritis Research and Therapy , 8, 4,

 

COUILLARD, J., DEMERS, M., LAVOIE, G. & ST-PIERRE, Y. (2006)
The role of DNA hypomethylation in the control of stromelysin gene expression
Biochemical and Biophysical Research Communications , 342, 4, 1233-1239

 

ST-PIERRE, Y. (2005)
Organizing a tête-à-tête between cell adhesion molecules and extracellular proteases: a risky business that could lead to the survival of tumor cells.
Frontiers in Bioscience , 10, 1040-1049
GRUSLIN, E., MOISAN, S., ST-PIERRE, Y., DESFORGES, M. & TALBOT, P. J. (2005)
Transcriptome profile within the mouse central nervous system and activation of myelin-reactive T cells following murine coronavirus infection
Journal of Neuroimmunology , 162, 1-2, 60-70

 

DEMERS, M. & ST-PIERRE, Y. (2005)
[Galectin-7: a novel gene associated with metastasis]
M S-Medecine Sciences , 21, 10, 790-792

 

DEMERS, M., MAGNALDO, T. & ST-PIERRE, Y. (2005)
A novel function for galectin-7: Promoting tumorigenesis by up-regulating MMP-9 gene expression
Cancer Research , 65, 12, 5205-5210

 

DEMERS, M., COUILLARD, J., BELANGER, S. & ST-PIERRE, Y. (2005)
New roles for matrix metalloproteinases in metastasis
Critical Reviews in Immunology , 25, 6, 493-523

 

BÉLANGER, S. D. & ST-PIERRE, Y. (2005)
Role of selectins in the triggering, growth, and dissemination of T-lymphoma cells: Implication of L-selectin in the growth of thymic lymphoma
Blood , 105, 12, 4800-4806

 

VAN THEMSCHE, C., POTWOROWSKI, E. F. & ST-PIERRE, Y. (2004)
Stromelysin-1 (MMP-3) is inducible in T lymphoma cells and accelerates the growth of lymphoid tumors in vivo
Biochemical and Biophysical Research Communications , 315, 4, 884-891

 

VAN THEMSCHE, C., ALAIN, T., KOSSAKOWSKA, A. E., URBANSKI, S., POTWOROWSKI, E. F. & ST-PIERRE, Y. (2004)
Stromelysin-2 (matrix metalloproteinase 10) is inducible in lymphoma cells and accelerates the growth of lymphoid tumors in vivo
Journal of Immunology , 173, 6, 3605-3611

 

ST-PIERRE, Y., COUILLARD, J. & VAN THEMSCHE, C. (2004)
Regulation of MMP-9 gene expression for the development of novel molecular targets against cancer and inflammatory diseases
Expert Opinion on Therapeutic Targets , 8, 5, 473-489

 

ST-PIERRE, Y., VAN THEMSCHE, C. & ESTÈVE, P. O. (2003)
Emerging features in the regulation of MMP-9 gene expression for the development of novel molecular targets and therapeutic strategies
Current Drug Targets — Inflammation and Allergy , 2, 3, 206-215

 

ROBLEDO, O., PAPAIOANNOU, A., OCHIETTI, B., BEAUCHEMIN, C., LEGAULT, D., CANTIN, A., KING, P. D., DANIEL, C., ALAKHOV, V. Y., POTWOROWSKI, E. F. & ST-PIERRE, Y. (2003)
ICAM-1 isoforms: specific activity and sensitivity to cleavage by leukocyte elastase and cathepsin G
European Journal of Immunology , 33, 5, 1351-1360

 

MOISAN, S., DEMERS, M., MERCIER, J., MAGNALDO, T., POTWOROWSKI, E. F. & ST-PIERRE, Y. (2003)
Upregulation of galectin-7 in murine lymphoma cells is associated with progression toward an aggressive phenotype
Leukemia , 17, 4, 751-759

 

BÉLIZAIRE, A. K., TCHISTIAKOVA, L., ST-PIERRE, Y. & ALAKHOV, V. (2003)
Identification of a murine ICAM-1-specific peptide by subtractive phage library selection on cells
Biochemical and Biophysical Research Communications , 309, 3, 625-630

 

VAN VALCKENBORGH, E., BAKKUS, M., MUNAUT, C., NOEL, A., ST PIERRE, Y., ASOSINGH, K., VAN RIET, I., VAN CAMP, B. & VANDERKERKEN, K. (2002)
Upregulation of matrix metalloproteinase-9 in murine 5T33 multiple myeloma cells by interaction with bone marrow endothelial cells
International Journal of Cancer , 101, 6, 512-8
OCHIETTI, B., LEMIEUX, P., KABANOV, A. V., VINOGRADOV, S., ST-PIERRE, Y. & ALAKHOV, V. (2002)
Inducing neutrophil recruitment in the liver of ICAM-1-deficient mice using polyethyleneimine grafted with pluronic P123 as an organ-specific carrier for transgenic ICAM-1
Gene Therapy , 9, 14, 939-945

 

OCHIETTI, B., GUÉRIN, N., VINOGRADOV, S. V., ST-PIERRE, Y., LEMIEUX, P., KABANOV, A. V. & ALAKHOV, V. Y. (2002)
Altered organ accumulation of oligonucleotides using polyethyleneimine grafted with poly(ethylene oxide) or pluronic as carriers
Journal of Drug Targeting , 10, 2, 113-121

 

GAUTHIER, C., ST-PIERRE, Y. & VILLEMUR, R. (2002)
Rapid antimicrobial susceptibility testing of urinary tract isolates and samples by flow cytometry
Journal of Medical Microbiology , 51, 3, 192-200

 

ESTÈVE, P. O., ROBLEDO, O., POTWOROWSKI, E. F. & ST-PIERRE, Y. (2002)
Induced expression of MMP-9 in C6 glioma cells is inhibited by PDGF via a PI 3-kinase-dependent pathway
Biochemical and Biophysical Research Communications , 296, 4, 864-869

 

ESTÈVE, P. O., CHICOINE, E., ROBLEDO, O., AOUDJIT, F., DESCOTEAUX, A., POTWOROWSKI, E. F. & ST-PIERRE, Y. (2002)
Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B
Journal of Biological Chemistry , 277, 38, 35150-35155

 

CHICOINE, É., ESTÈVE, P. O., ROBLEDO, O., VAN THEMSCHE, C., POTWOROWSKI, E. F. & ST-PIERRE, Y. (2002)
Evidence for the role of promoter methylation in the regulation of MMP-9 gene expression
Biochemical and Biophysical Research Communications , 297, 4, 765-772

 

MISSÉ, D., ESTÈVE, P. O., RENNEBOOG, B., VIDAL, M., CERUTTI, M., ST-PIERRE, Y., YSSEL, H., PARMENTIER, M. & VEAS, F. (2001)
HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway
Blood , 98, 3, 541-7

 

GRAZIANO, M., ST-PIERRE, Y. & POTWOROWSKI, E. F. (2001)
UEA-I-binding to thymic medullary epithelial cells selectively reduces numbers of cortical TCR alpha beta(+) thymocytes in FTOCs
Immunology Letters , 77, 3, 143-150

 

GIRARD, M., CLÉROUX, P., TREMBLAY, P., DEA, S. & ST-PIERRE, Y. (2001)
Increased proteolytic activity and matrix metalloprotease expression in lungs during infection by porcine reproductive and respiratory syndrome virus
Journal of General Virology , 82, 6, 1253-1261

 

DE NONCOURT, P., ROBLEDO, O., ALAIN, T., KOSSAKOWSKA, A. E., URBANSKI, S. J., POTWOROWSKI, E. F. & ST-PIERRE, Y. (2001)
Leukocyte elastase in murine and human non-Hodgkin lymphomas
Journal of Leukocyte Biology , 70, 4, 585-591

 

CLARKE, A. E., ST-PIERRE, Y., JOSEPH, L., PENROD, J., SIBLEY, J. T., HAGA, M. & GENANT, H. K. (2001)
Radiographic damage in rheumatoid arthritis correlates with functional disability but not direct medical costs
Journal of Rheumatology , 28, 11, 2416-2424

 

THOMAS, J. C., ST-PIERRE, Y., BEAUDET, R. & VILLEMUR, R. (2000)
Monitoring by laser-flow-cytometry of the polycyclic aromatic hydrocarbon-degrading Sphingomonas sp strain 107 during biotreatment of a contaminated soil
Canadian Journal of Microbiology , 46, 5, 433-440

 

THOMAS, J. C., ST-PIERRE, Y., BEAUDET, R. & VILLEMUR, R. (2000)
Erratum: Monitoring by laser-flow-cytometry of the polycyclic aromatic hydrocarbon-degrading Sphingomonas sp. strain 107 during biotreatment of a contaminated soil (Canadian Journal of Microbiology (2000) 46 (433-440))
Canadian Journal of Microbiology , 46, 9, 866

 

THERRIEN, D., ST-PIERRE, Y. & DEA, S. (2000)
Preliminary characterization of protein binding factor for porcine reproductive and respiratory syndrome virus on the surface of permissive and non-permissive cells
Archives of Virology , 145, 6, 1099-1116

 

ST-PIERRE, Y. & POTWOROWSKI, E. F. (2000)
T cell control of extracellular matrix degradation
Developmental Immunology , 7, 2-4, 171-177

 

LEMIEUX, P., VINOGRADOV, S. V., GEBHART, C. L., GUÉRIN, N., PARADIS, G., NGUYEN, H. K., OCHIETTI, B., SUZDALTSEVA, Y. G., BARTAKOVA, E. V., BRONICH, T. K., ST-PIERRE, Y., ALAKHOV, V. Y. & KABANOV, A. V. (2000)
Block and graft copolymers and Nanogel (TM) copolymer networks for DNA delivery into cell
Journal of Drug Targeting , 8, 2, 91-105

 

LALANCETTE, M., AOUDJIT, F., POTWOROWSKI, E. F. & ST-PIERRE, Y. (2000)
Resistance of ICAM-1-deficient mice to metastasis overcome by increased aggressiveness of lymphoma cells
Blood , 95, 1, 314-319