Organometallic Chemistry Laboratory for the Design of Catalysts and Therapeutics

The Organometallic Chemistry Laboratory for the Design of Catalysts and Therapeutics operates in the field of medicinal chemistry, particularly the development of multitasking organometallic therapeutics

At the interface of chemistry and biology, work at the Organometallic Chemistry Laboratory for the Design of Catalysts and Therapeutics also includes research on targeted thermoresponsive drug delivery systems, the development of C-H bond activation catalysts, and the isolation of antibiotics.

The facility boasts state-of-the-art equipment and provides services such as proteomic analysis (identification of proteins) and mass spectrometry (identification of organic molecules, analysis of natural products, and quantification of pharmaceutical metabolites).

The Organometallic Chemistry Laboratory for the Design of Catalysts and Therapeutics is equipped with:

 

A mass spectrometer

This instrument features a Micromass Quattro II triple quadrupole equipped with gas and liquid chromatography interfaces. It can operate in positive and negative mode and can perform mass scans up to 4000 m/z.
It also has a gas chromatography interface with an HP 6890 gas chromatograph and a liquid chromatography interface with an HP 1100 HPLC system equipped with an auto injector and UV detector.

 

Peptide and protein analysis software

Information will be coming soon

 

Applied Biosystems Q-Trap 2000

This is coupled to an Agilent nanopump to perform capillary liquid chromatography and can operate in direct infusion mode as well as in positive and negative modes.

The laboratory has state-of-the-art equipment and provides services such as proteomic analysis (identification of proteins) and mass spectrometry (identification of organic molecules, analysis of natural products, and quantification of pharmaceutical metabolites).

 

Proteomic analysis

The proteomic analysis service is available to the scientific community for identifying proteins isolated from microorganisms or tissues of higher organisms.

Analyses can be done at scan ranges up to 1700 m/z, and a variety of MS/MS experiments can also be performed, including daughter ion, parent ion, and neutral fragment loss analysis. The instrument uses various ionization modes such as electrospray and nanospray. It can also provide information on the mass of triptych peptides and their amino acid sequences and can be used to determine post-translational changes such as phosphorylation, the addition of sugars to proteins, and more.

Proteomic analysis is overseen by Professor Annie Castonguay, with analyses carried out by A. Nikolakakis (M.Sc. Microbiology).

 

Fees

  • University community: $60 per analysis
  • Industry: $120 per analysis

Fees include sample preparation such as the bleaching of electrophoresis gel sections, triptych digestion, and the extraction of peptides from gel.

 

Mass spectrometry

The mass spectrometry service is available to the scientific community. It can be used to identify organic molecules, analyze natural products, quantify pharmaceutical metabolites, analyze trace pollutants, determine the molecular weight of proteins, sequence peptides, and more.

A variety of MS/MS experiments can be performed, such as daughter ion, parent ion, and neutral fragment loss analysis. Various ionization modes are used, including electron impact (EI), chemical ionization (CI), atmospheric pressure chemical ionization (APCI), electrospray, and nanospray.

Peptide and protein analysis software is also available as part of the service.

 

Fees

  • University community: $60 per analysis
  • Industry: $120 per analysis

 

An hourly rate can also be negotiated for projects involving multiple analyses using the same method. Feel free to contact us to discuss your needs.

The Organometallic Chemistry Laboratory for the Design of Catalysts and Therapeutics is funded by the Canada Foundation for Innovation (CFI) and the Government of Quebec.

Contacts

Annie Castonguay
Professor and Scientific leader
Phone: 450-687-5010, ext. 8850
Email: annie.castonguay@inrs.ca

Organometallic Chemistry Laboratory for the Design of Catalysts and Therapeutics

Institut national de la recherche scientifique

Armand-Frappier Santé Biotechnologie Research Centre

531 boul. des Prairies

Laval, Quebec  H7V 1B7

Canada

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Castonguay Research Group