Project Description:
This project is part of a large interdisciplinary and inter-university (Institut National de la Recherche Scientifique, McGill university, Montreal Heart Institute) study aimed at understanding the molecular and cellular pharmacology of the urotensinergic system and its roles in the development and progression of cardiovascular diseases. The urotensinergic system consists of a G protein-coupled receptor (GPCR), known as UT, and two endogenous peptide ligands. Several studies on animal models have demonstrated the therapeutic potential of this system. In order to continue the development of effective ligands in vivo, it is important to better understand the cellular and molecular mechanisms involved in the interaction and activation of the UT receptor by its ligands. Traditionally used to measure the binding affinity of a ligand for its receptor, binding studies using radiolabeled peptides have several drawbacks, including health risks associated with handling radioactive chemicals, the cost of radioactive sources and waste management. This master’s project aims to develop and validate a new method to assess the binding affinity of peptide ligands using a cutting-edge biophysical technique based on microscale thermophoresis.
Research Areas
- Medicinal Chemistry
- Pharmacology
- Cellular and Molecular Biology
Research Supervisors
David Chatenet, Professor
Juliana Dallagnol, Research Associate
Study Programs
This study project will be carried out under the following program: Master’s degree in Experimental Health Sciences.
Desired Profile
- Hold a bachelor’s degree in biology, biochemistry, pharmacology, chemistry, or a related field
- Be open to collaborating with an interdisciplinary team working in different research area
- Have a curious, resourceful, and autonomous mindset
- Have a good fluency on both French and English
Applicants with knowledge or experience in some or all of the following areas are encouraged to apply:
- GPCR pharmacology
- Organic/peptidic synthesis
- Cell biology
Financial Support
INRS offers many scholarship programs. Every student will benefit from a scholarship during their higher education studies.
Location
Centre Armand-Frappier Santé Biotechnologie
531, boulevard des Prairies
Laval (Québec) H7V 1B7
Canada
How to apply
Interested persons can submit their application in a single PDF file by using the online form. The application must include:
- Motivation letter describing their research interests
- Complete CV
- A statement of all your academic transcripts
- The name of two contact information for further reference.
We encourage women, visible minorities, ethnic minorities, aboriginals and people with disabilities to apply.