Project Description
A growing number of studies showed that G protein-coupled receptors (GPCR) not only exist as isolated entities but also interact within the plasma membrane by forming receptor dimers or higher-order oligomers. Besides enabling cross-talk between individual signaling networks, receptor dimerization can induce activation of alternative signaling pathways and influence ligand pharmacology. Moreover, GPCR heterodimer distribution is expected to be much more restricted than GPCR monomers, which suggests that targeting specific dimers linked to pathophysiological signaling properties may constitute an appealing strategy for the development of drugs with improved efficacy and specificity. Known as a critical therapeutic target in heart failure, the angiotensinergic system interacts with the urotensinergic system, this interplay allosterically modulating their respective signaling signature and thus potentially defining a potentially unique role for this GPCR complexes in cardiovascular physiology and pathophysiology. Further knowledge and tools are however mandatory to validate such complexes as potential therapeutic targets. The objectives of this project are to:
- Develop innovative tools to reveal these complexes in native environment;
- Define allosteric interactions, signaling profiles and phenotypic responses associated with these complexes;
- Design bivalent ligands to study the pharmacology and biology of these complexes.
Research Areas
- Medicinal Chemistry
- Pharmacology
- Cellular and Molecular Biology
Research Supervisors
- David Chatenet, Professor
- Terence E. Hébert, Professor (McGill university)
- Juliana Dallagnol, Research Associate
Study Programs
This study project will be carried out under the following program: Ph.D. in Biology (French description)
Desired Profile
- Hold a master’s degree in biology, biochemistry, pharmacology, chemistry, or a related research field;
- Be open to collaborating with an interdisciplinary team working in different research areas;
- Have a curious, resourceful, and autonomous mindset;
- Have a good fluency on both French and English.
Applicants with knowledge or experience in some or all of the following areas are encouraged to apply:
- GPCR pharmacology
- Organic/peptidic synthesis
- Compounds purification using various chromatographic methods
- Cell biology
Financial Support
INRS offers many scholarship programs. Every student will benefit from a scholarship during their higher education studies.
Location
Armand-Frappier Santé Biotechnologie Research Centre
531, boulevard des Prairies
Laval (Québec) H7V 1B7
How to apply
Interested persons can submit their application in a single PDF file by using the online form. The application must include:
- Motivation letter (maximum 1 page) describing their research interests
- Complete CV
- A statement of all your academic transcripts
- The name of three contact information for further reference.
We encourage women, visible minorities, ethnic minorities, aboriginals and people with disabilities to apply.