Project title : Unlocking the Potential of Electrochemistry to Assess Neurochemical Changes in Brain: Development of New Electrodes for Enhanced Neurotransmitter Measurement
Project description
The human brain, composed of about 100 billion neurons, relies on electrochemical processes for neuronal communication. Axonal action potentials, essential for information transmission between neurons, depend on the regulated flow of ionic currents across neuronal membranes. Understanding these electrochemical dynamics is fundamental to neuroscience, as they reveal how brain function and communication are regulated. Neurotransmitters—small molecules and neuropeptides—are vital for synaptic communication, but their roles and interactions are not fully understood. This gap contributes to brain diseases and psychiatric disorders, highlighting the need for advanced tools to detect neurotransmitters with high sensitivity.
Our proposed project aims to develop next-generation electrochemical sensors using simple carbon fibers integrated with carbon nanotubes or chains of carbon spheres. These sensors will offer increased sensitivity, selectivity, and reproducibility. By integrating fast cyclic voltammetry (FSCV) with these innovative electrodes and testing them both in the laboratory and in live environments, we aim to detect neurotransmitter fluctuations in real time. This approach will provide crucial insights into neurotransmitter dynamics and improve diagnostic and treatment methods for related disorders.
Achieving the project’s goals could significantly advance our understanding of brain function, stimulate technological innovation, and offer substantial social and economic benefits. Specifically, the project holds potential for significant impact in Quebec by fostering valuable research partnerships and strengthening public engagement. The development of cutting-edge technologies and interdisciplinary collaborations could position Canada and Quebec as leaders in neuroscience research and innovation.
This project is a collaboration with the Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University. The Energy Materials Telecommunications (EMT) Centre of INRS provides a bilingual French/English environment.
The INRS Energy Materials Telecommunications Center (EMT) offers a bilingual French/English environment.
Start date
Summer 2025
Supervision
Mohamed Mohamedi
Programs of study
PhD in energy and materials sciences
Required qualifications
- Master’s degree in electrochemistry, neuroscience, neurochemistry or a related field
- Experience in microelectrode fabrication will be considered an asset
Only candidates with excellent academic records will be considered. We thank all applicants for their interest; however, only those who are qualified will be contacted for an interview. The application will remain open until the position is filled.
Scholarship
INRS offers many scholarship programs. Every student-researcher benefits from a grant during their graduate studies.
Location
Énergie Matériaux Télécommunications Research Center
1650, Boulevard Lionel-Boulet
Varennes (Québec) J3X 1P7
Canada
How to Apply
If you are interested in the position, you can apply to Mohamed Mohamedi by using the online form. Please include:
- Detailed CV with the list of scientific publications
- Cover letter clearly stating the interests and relevance of the research experience with the proposed topics (two pages maximum)
- The names and contact details of three people who can provide professional references
- A copy of your most recent transcripts