Areas of expertise
Microbiology and immunology , Identification and characterization of bacterial genes affecting humans, poultry and pigs
- Professor agrégé
Armand-Frappier Santé Biotechnologie Research Centre
531 des Prairies Blvd.
Laval, Quebec H7V 1B7
CANADA
Research interests
- Bacterial gene regulation and expression during infection
- Vaccine development
- Enterobacterial pathogens causing diseases of importance to human and animal health
- Microbial metal transport in pathogenic bacteria including Escherichia coli, Salmonella, and Klebsiella
- Bacterial comparative and functional genomics
International Innovation, octobre 2013, page 48, INRS-Institut Armand-Frappier Research Centre
Dr. Charles M. Dozois received a B.Sc. (Agr.) in Biological Sciences from the Faculty of Agriculture of McGill University (1990), an M.Sc. (1993) in Veterinary Microbiology from the Faculty of Veterinary Medicine of the University of Montreal, and a Ph. D.(1995) in Microbiology-Immunology from the Faculty of Medicine of the University of Montreal.
Following work as a postdoctoral fellow in immunology at INRA (Toulouse, France) and a research associateship at the Dept. of Biology of Washington University (Saint-Louis, MO, USA), he joined the INRS – Institut Armand-Frappier as a professor in 2001.
His research centres on further understanding the mechanisms of host-pathogen interactions. In particular, Dr. Dozois is interested in the identification and characterisation of bacterial genes that are expressed in vivo during infection of the host and the discovery of new microbial systems that contribute to pathogenesis.
Publications
List of theses and master in direction
O’Dowd, Kelsey; Isham, Ishara M; Vatandour, Safieh; Boulianne, Martine; Dozois, Charles M. ; Gagnon, Carl A; Barjesteh, Neda et Abdul-Careem, Mohamed Faizal (2024). Host Immune Response Modulation in Avian Coronavirus Infection: Tracheal Transcriptome Profiling In Vitro and In Vivo Viruses , vol. 16 , nº 4:605. pp. 1-31. DOI: 10.3390/v16040605.
Winter, Kaitlin; Houle, Sébastien; Dozois, Charles M. et Ward, Brian J. (2024). Multimodal vaccination targeting the receptor binding domains of Clostridioides difficile toxins A and B with an attenuated Salmonella Typhimurium vector (YS1646) protects mice from lethal challenge Microbiology Spectrum , nº e0310922. DOI: 10.1128/spectrum.03109-22.
Jamali, Hossein; Akrami, Fariba; Bouakkaz, Souhaib et Dozois, Charles M. (2024). Prevalence of specific serogroups, antibiotic resistance and virulence factors of avian pathogenic Escherichia coli (APEC) isolated from clinical cases: A systematic review and meta-analysis Microbial Pathogenesis , vol. 194 , nº 106843. pp. 1-17. DOI: 10.1016/j.micpath.2024.106843.
Klemberg, Vivian Souza; Pavanelo, Daniel Brisotto; Houle, Sébastien; Dhakal, Sabin; Pokharel, Parvil; Iahnig-Jacques, Simone; Dozois, Charles M. et Horn, Fabiana (2024). The osmoregulated metabolism of trehalose contributes to production of type 1 fimbriae and bladder colonization by extraintestinal Escherichia coli strain BEN2908 Frontiers in Cellular and Infection Microbiology , vol. 14 , nº 1414188. pp. 1-13. DOI: 10.3389/fcimb.2024.1414188.
Gaougaou, Ghizlane; Vincent, Antony T.; Krylova, Kateryna; Habouria, Hajer; Bessaiah, Hicham; Baraketi, Amina; Veyrier, Frédéric ; Dozois, Charles M. ; Déziel, Éric et Lacroix, Monique (2023). Adaptive Radioresistance of Enterohemorrhagic Escherichia coli O157:H7 Results in Genomic Loss of Shiga Toxin-Encoding Prophages Applied and Environmental Microbiology , vol. 89 , nº 4:e01306. pp. 1-10. DOI: 10.1128/aem.01306-22.
Ou, Camille; Dozois, Charles M. et Daigle, France (2023). Differential regulatory control of curli (csg) gene expression in Salmonella enterica serovar Typhi requires more than a functional CsgD regulator Scientific reports , vol. 13 , nº 14905. pp. 1-14. DOI: 10.1038/s41598-023-42027-y.
Hassan, Adam S; Houle, Sébastien; Labrie, Lydia; Perera, Dilhan J; Dozois, Charles M. ; Ward, Brian J. et Ndao, Momar (2023). Salmonella Typhimurium expressing chromosomally integrated Schistosoma mansoni Cathepsin B protects against schistosomiasis in mice NPJ Vaccines , vol. 8 , nº 1:27. pp. 1-13. DOI: 10.1038/s41541-023-00599-w.
Pokharel, Parvil; Dhakal, Sabin et Dozois, Charles M. (2023). The Diversity of Escherichia coli Pathotypes and Vaccination Strategies against This Versatile Bacterial Pathogen Microorganisms , vol. 11 , nº 2:344. pp. 1-54. DOI: 10.3390/microorganisms11020344.
Habouria, Hajer; Bessaiah, Hicham; Pokharel, Parvil; Dhakal, Sabin; Maris, Ségolène; Buron, Jukie; Houle, Sébastien et Dozois, Charles M. (2022). A Newly Identified Group of P-like (PL) Fimbria Genes from Extraintestinal Pathogenic Escherichia coli (ExPEC) Encode Distinct Adhesin Subunits and Mediate Adherence to Host Cells Applied and Environmental Microbiology , vol. [ahead of . e0142121. DOI: 10.1128/aem.01421-21.
Habouria, Hajer; Bessaiah, Hicham; Pokharel, Pravil; Dhakal, Sabin; Maris, Ségolène; Buron, Julie; Houle, Sébastien et Dozois, Charles M. (2022). A Newly Identified Group of P-like (PL) Fimbria Genes from Extraintestinal Pathogenic Escherichia coli (ExPEC) Encode Distinct Adhesin Subunits and Mediate Adherence to Host Cells Applied and Environmental Microbiology , vol. 88 , nº 13. e0142121. DOI: 10.1128/aem.01421-21.
Bessaiah, Hicham; Pokharel, Parvil; Loucif, Hamza; Kulbay, Merve; Sasseville, Charles; Habouria, Hajer; Houle, Sébastien; Bernier, Jacques ; Massé, Éric; van Grevenynghe, Julien et Dozois, Charles M. (2021). The RyfA small RNA regulates oxidative and osmotic stress responses and virulence in uropathogenic Escherichia coli PLoS Pathogens , vol. 17 , nº 5. pp. 1-31. DOI: 10.1371/journal.ppat.1009617.
Bessaiah, Hicham; Anamalé, Carole; Sung, Jacqueline et Dozois, Charles M. (2021). What Flips the Switch? Signals and Stress Regulating Extraintestinal Pathogenic Escherichia coli Type 1 Fimbriae (Pili) Microorganisms , vol. 10 , nº 5. pp. 1-26. DOI: 10.3390/microorganisms10010005.
Pokharel, Parvil; Diaz, Jérémy; Bessaiah, Hicham; Houle, Sébastien; Guerrero-Barrera, a et Dozois, Charles M. (2020). The Serine Protease Autotransporters TagB, TagC, and Sha from Extraintestinal Pathogenic Escherichia coli Are Internalized by Human Bladder Epithelial Cells and Cause Actin Cytoskeletal Disruption International Journal of Molecular Sciences , vol. 21 , nº 9:e3047. pp. 1-23. DOI: 10.3390/ijms21093047.