Areas of expertise
Virus-host interactions
- Associate Professor
Armand-Frappier Santé Biotechnologie Research Centre
531 des Prairies Blvd.
Laval, Quebec H7V 1B7
Canada
Dr Rodrigue-Gervais obtained his B.Sc. in Biology (2000) from the Faculté des Sciences de l’Université du Québec à Montréal and his M.Sc. (2005) and Ph.D. in Virology and Immunology (2008) from Université de Montréal. As a grad student in the labs of Rafick-Pierre Sékaly and Daniel Lamarre, he showed that dendritic cells (through cytokine signals) act as rheostat to control cell death by enabling CD8+ T-cell exhaustion using the Hepatis C virus infection model. He later did his postdoctoral training in biochemistry and genetics with Maya Saleh at McGill University (2010-2016). There, Dr Rodrigue-Gervais continued to study the control of cell death in infection and demonstrated how the inhibitor of apoptosis protein CIAP2 shapes the cell death defense to influenza A virus, dictating disease outcome.
Dr Rodrigue-Gervais started his own lab after joining the faculty of INRS-Institut Armand-Frappier (INRS-IAF) in the Sumer of 2016. Studies in his lab are principally designed to understand at a systems level the regulation of cell survival and adaptation to stress during respiratory viral infections.
Publications
14. Dupaul-Chicoine J, Arabzadeh A, Dagenais M, Douglas T, Champagne C, Morizot A, Rodrigue-Gervais IG, Breton V, Colpitts SL, Beauchemin N, Saleh M. The Nlrp3 inflammasome suppresses colorectal cancer metastatic growth in the viver by promoting natural killer cell tumoricidal activity. Immunity. 2015. 43(4):751-63. PMID:26384545
13. Rodrigue-GervaisIG, Rigsby H, Jouan L, Willems B, Lamarre D. Intact dendritic cell pathogen-recognition receptor functions associate with chronic hepatitis C treatment-induced viral clearance. PLoS One. 2014. 9(7):e102605. PMID: 25033043
12. Rodrigue-Gervais IG*, Labbé K*, Dagenais M, Dupaul-Chicoine J, Champagne C, Morizot A, Skeldon A, Brincks EL, Vidal SM, Griffith TS, Saleh M. Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival. Cell Host Microbe. 2014. 15(1):23-35. PMID:24439895 (*Equal contributions)
11. Rodrigue-Gervais IG, Saleh M. Caspases and immunity in a deadly grip. Trends Immunol. 2013. 34(2):41-9. PMID:23069594
10. Jouan L, Chatel-Chaix L, Melançon P, Rodrigue-Gervais IG, Raymond VA, Selliah S, Bilodeau M, Grandvaux N, Lamarre D. Targeted impairment of innate antiviral responses in liver of chronic Hepatitis C patients. J Hepatol. 2012. 56(1):70-7. PMID:21835140
9. Bongfen SE, Rodrigue-Gervais IG, Berghout J, Torre S, Cingolani P, Wiltshire SA, Leiva-Torres GA, Letourneau L, Sladek R, Blanchette M, Lathrop M, Behr MA, Gruenheid S, Vidal SM, Saleh M, Gros P. An N-ethyl-N-nitrosourea (ENU)-induced mutation in JAK3 protects against cerebral malaria but causes susceptibility to mycobacteriaPLoS One. 2012. 7(2):e31012. PMID:22363534
8. Liu X, Nugoli M, Laferrière J, Saleh SM, Rodrigue-Gervais IG, Saleh M, Park M, Hallett MT, Muller WJ, Giguère V. Stromal retinoic acid receptor beta promotes mammary gland tumorigenesis. Proc Natl Acad Sci U S A. 2011. 108(2):774-9. PMID:21187396
7. Rodrigue-Gervais IG, Lamarre D. Hepatitis C virus subverts PRR-mediated control of adaptive immunity orchestrated by DCs. 2010. Med Sci (Paris). 26(10):869-74. PMID:20929679
6. Rodrigue-Gervais IG, Rigsby H, Jouan L, Sauvé D, Sékaly RP, Willems B, Lamarre D. Dendritic cell inhibition is connected to exhaustion of CD8+ T cell polyfunctionality during chronic hepatitis C virus infection. J Immunol. 2010. 184(6):3134-44. PMID:20173023
5. Rodrigue-Gervais IG, Saleh M. Genetics of inflammasome-associated disorders: a lesson in the guiding principles of inflammasome function. Eur J Immunol. 2010. 40(3):643-8. PMID:20201021
4. Jouan L, Melançon P, Rodrigue-Gervais IG, Raymond VA, Selliah S, Boucher G, Bilodeau M, Grandvaux N, Lamarre D. Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease. J Hepatol. 2010. 52(2):167-75. PMID:20006398
3. Voisin L, Julien C, Duhamel S, Gopalbhai K, Claveau I, Saba-El-Leil MK, Rodrigue-Gervais IG, Gaboury L, Lamarre D, Basik M, Meloche S. . Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors. BMC Cancer. 2008. 8:337. PMID:19014680
2. Rodrigue-Gervais IG, Jouan L, Beaulé G, Sauvé D, Bruneau J, Willems B, Sékaly RP, Lamarre D.Poly(I:C) and LPS innate sensing functions of circulating human myeloid dendritic cells are affected in vivo in Hepatitis C virus-infected patients.J Virol. 2007 Jun;81(11):5537-46. PMID:17376921
1. Wilson JA, Jayasena S, Khvorova A, Sabatinos S, Rodrigue-Gervais IG, Arya S, Sarangi F, Harris-Brandts M, Beaulieu S, Richardson CD. RNA interference blocks gene expression and RNA synthesis from Hepatitis C replicons propagated in human liver cells.Proc Natl Acad Sci USA. 2003.100(5):2783-8. PMID:12594341