Areas of expertise
Epidemiology, Inflammatory and autoimmune diseases , Asthma , Cancer , COVID-19 , Diabetes , Inflammatory bowel disease , Multiple sclerosis
- Full Professor
- Scientific Manager, Québec BCG Vaccination Registry
Armand-Frappier Santé Biotechnologie Research Centre
531 des Prairies Blvd.
Laval, Quebec H7V 1B7
Canada
Research interests
The research activities of Dr. Marie-Claude Rousseau are carried in the field of epidemiology and they are focused on inflammatory, auto-immune and infectious diseases. Her work focuses on three main themes related to these diseases:
- the study of factors influencing the immune response and their role in etiology;
- the study of lifestyle and environmental exposures as potential risk or protective factors;
- the evaluation of health services utilization among persons suffering from these diseases.
Future students
Master’s and PhD students, and post-doctoral fellows interested in joining Dr. Rousseau’s research team may communicate with her by email.
Dr. Marie-Claude Rousseau obtained a bachelor’s degree (B.Sc.) in biochemistry from Université du Québec a Montréal in 1991. Her graduate studies were conducted at McGill University, where she earned a M.Sc. (1998) and Ph.D. (2003) in Epidemiology & Biostatistics.
With a postdoctoral fellowship from the National Cancer Institute of Canada, she joined Dr Jack Siemiatycki ‘s research chair in Environmental Epidemiology and Population Health at Université de Montréal’s Department of social and preventive medicine (2003-2004). In 2005, she joined INRS-Institut Armand-Frappier as a Professor.
Her research activities, funded by the Canadian Institutes for Health Research (CIHR), the Canadian Cancer Society, the Multiple Sclerosis Society of Canada, and the Fonds de recherche du Québec – Santé (FRQS), consist in epidemiological studies on the etiology of inflammatory, autoimmune and infectious diseases (asthma, diabetes, multiple sclerosis, inflammatory bowel disease, cancer, and COVID-19).
Can anti-tuberculosis vaccination help decrease mortality and infections?
Research Team
- Marie-Claude Rousseau, INRS (Principal investigator)
- Andrea Benedetti, McGill University
- Dick Menzies, McGill University
- Marie-Élise Parent, INRS
- Jacques Pépin, Université de Sherbrooke
- Philippe De Wals, Université Laval
- Maziar Divangahi, McGill University
The bacillus Calmette-Guerin (BCG) vaccine used in tuberculosis prevention may lower mortality in babies and children, and prevent infectious diseases other than tuberculosis. Recent studies have suggested that it may also protect against COVID-19 and prevent mortality from this disease. These recent investigations were limited because they only looked at correlations between having a BCG vaccination program and COVID-19 mortality rates. Studies need to be conducted in populations where there are vaccination, disease and mortality registries, so that we know exactly who was vaccinated, who had the disease and who died. In the Province of Quebec, a BCG vaccination campaign took place between 1949 and the mid-1970s. The vaccine was offered for free to newborns and schoolchildren, and vaccination information is compiled in a registry.
The goal of our study is to determine if BCG vaccination in early life is associated with decreased mortality and with risk of infections over the life course. We will study selected bacterial and viral infections, and also infections with SARS-CoV-2, the virus causing COVID-19.
The study population consists of 400,000 persons. This is almost all individuals born in Quebec between 1970 and 1974. They are now aged 47 to 51 years old. Data was already obtained from provincial administrative databases until 2014, including BCG vaccination status, sociodemographic factors, and death if applicable. We will obtain data on mortality and on use of health services for infections from provincial databases until 2021. We will compare the rates of mortality and of infections (with bacterial and viral infections and with COVID-19 separately) among persons who received the BCG vaccine and those who did not.
There are few places in the world where this type of study can be done. Our unique setting will allow us to answer several important questions on BCG vaccination, helping us understand its effects beyond tuberculosis prevention.
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Studying inflammatory bowel disease etiology: a life course approach
Research Team
- Marie-Claude Rousseau, INRS (Principal investigator)
- Prévost Jantchou, CHU Sainte-Justine (Co-principal investigator)
- Andrea Benedetti, McGill University
- Sylvie Girard, CHU Sainte-Justine
- Sreenath Madathil, McGill University
- Belinda Nicolau, McGill University
- Shu Qin Wei, CHU Sainte-Justine
Inflammatory bowel disease is a chronic disease of the gut. It affects digestion and absorption of food, and elimination of waste. Its causes are unknown. After many studies, researchers have only been able to identify a few risk factors with certainty. They include family history of the disease and cigarette smoking. The causes of this disease are still unknown, but some researchers think that certain times in life could be more critical for the development of the disease.
Our goal is to clarify the causes of disease, and identify which ones could be targeted by prevention program. We are studying medical, environmental, lifestyle, and psychosocial factors from the time of birth until adult years to determine if they are linked to the development of the disease. These factors are for example: prematurity, breastfeeding, antibiotic use, diet, smoking, stress. We also study carefully when these factors occur during a person’s life. For this research, we are using a cohort of about 400,000 persons born between 1970 and 1974, in the province of Quebec. We created this cohort by linking together some provincial administrative databases. Data on medical services and hospitalizations for inflammatory bowel disease were obtained until 2014 and have been used to determine who is affected by the disease. We will ask about 2600 persons of the cohort to complete a web survey to collect information on the factors of interest. Among the participants, we will compare persons who have the disease to those who do not, and evaluate what are the key moments throughout their lives when these factors could affect the risk of the disease.
This research will help understanding which factors increase the risk of inflammatory bowel disease by detecting if there are certain times in a person’s life that are especially important for etiology. This will allow us to generate crucial information to establish prevention programs.
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Does BCG protect against SARS-CoV-2 infection: a multicenter case-control study
Research team
- Alex Carignan, Université de Sherbrooke (Principal investigator)
- Jacques Pépin, Université de Sherbrooke
- Marie-Claude Rousseau, INRS
- Marie-Élise Parent, INRS
- Louis Valiquette, Université de Sherbrooke
- Annie-Claude Labbé, Université de Montréal
- Philippe De Walls, Université Laval
The Bacillus Calmette-Guérin vaccine (BCG), administered to prevent tuberculosis and its complications, stimulates innate immunity, which then becomes ‘trained’, leading to non-specific effects against a broad range of bacteria and viruses. Some innate immune cells display intrinsic long-term memory. For tuberculosis, the protection conferred by BCG lasts for at least 30 years, and perhaps as long as 50 years. Non-specific, ‘off-target’, effects of BCG may also persist for many years after vaccination. At the beginning of the COVID-19 pandemic caused by the SARS-CoV-2 virus and for which no vaccine was yet available, the hypothesis of a protection by the BCG was formulated. Multiple ecological studies reported a decrease in COVID-19 incidence in countries with a universal vaccination program to BCG. These studies, however, presented important methodological limitations.
The aim of our study was to determine whether BCG administered at least 40 years ago decreases the risk of SARS-CoV-2 infection.
We used a case-control study design, in which cases were persons who tested positive for SARS-CoV-2, and controls were individuals who had a laboratory test done, other than for a respiratory illness or SARS-CoV-2, during the same period. Two institutions took part in the study: the CIUSSS Estrie (Centre Hospitalier Universitaire de Sherbrooke) and the CIUSSS de l’Est de l’Île de Montréal (Maisonneuve-Rosemont Hospital), where approximately 900 cases and 2100 controls were recruited. Included participants were limited to individuals born in Quebec and aged between 45 and 64 years old. This study took advantage of different factors unique to the province of Quebec: i) a BCG vaccination program, through which about half of the children in Quebec received the vaccine from 1956 to 1976; ii) a computerized vaccination registry of all persons who received the BCG in Quebec since 1956, available at the Institut National de la Recherche Scientifique; and iii) a high incidence of SARS-CoV-2 infections in the province of Quebec, especially in Montreal. We linked data obtained from the participants to the vaccination registry to determine who received the BCG vaccine. Then we determined with statistical analyses whether the risk of infection to SARS-CoV-2 was reduced among vaccinees.
Our study is the first ever specifically designed to investigate this question using individual data. Access to COVID-19 vaccines varies greatly from country to country, making it useful to identify all potential prevention tools and measures. The results of this research will be shared shortly.
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Potential health effects from non-specific stimulation of the immune system in early age through vaccination with Bacille Calmette-Guérin (BCG)
PROJECT ON LYMPHOMA
Research Team
- Marie-Claude Rousseau, INRS (Principal investigator)
- Andrea Benedetti, McGill University
- Marie-Élise Parent, INRS
PROJECT ON MULTIPLE SCLEROSIS
Research Team
- Marie-Claude Rousseau, INRS (Principal investigator)
- Christina Wolfson, McGill University
- Andrea Benedetti, McGill University
- Nathalie Arbour, CHUM, Université de Montréal
- Pierre Duquette, CHUM, Université de Montréal
- Marie-Élise Parent, INRS
Several studies have suggested a possible link between vaccination, childhood infections and the development of the immune system. The BCG vaccine stimulates macrophages, which in turn induce the production of cytokines by TH1 lymphocytes. Epidemiological results on the health effects of BCG vaccination are contradictory. Some studies have suggested a decreased incidence of asthma, allergies, and type-1 diabetes among vaccinated individuals. The BCG vaccine has been suggested as a potential preventive factor against leukemia and melanoma, but as a risk factor for non-Hodgkin’s lymphoma and Hodgkin’s disease.
A BCG vaccination program took place in Quebec from 1949 to 1974, initiated by Dr Armand Frappier himself. The vaccination certificates for the entire province were sent to the central registry, still kept at Centre Armand-Frappier Santé Biotechnologie within INRS. The registry was computerized through a grant from the Canada Foundation for Innovation (Leaders Opportunity Fund). The overall objective of these projects is to determine whether a non-specific stimulation of the immune system in early life, as resulting from BCG vaccination, is associated with beneficial or adverse health effects. The BCG vaccination registry is a unique resource with enormous potential to answer questions about the potential off-target effects of this vaccine. We have demonstrated the feasibility and validity of linking this data source to administrative databases available in Quebec [birth and death registries, Med-Écho (hospitalizations), RAMQ (medical services)].
Our current work will open the door to studies focusing on the link between immunity, infections, and several chronic diseases. The information acquired thereof will go way beyond the BCG vaccination itself. It has the potential to provide leads into a better understanding of the role of immunostimulation early in life and of mechanistic processes involved in the development of chronic diseases characterized by an inflammatory or autoimmune process.
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Workplace exposures and prostate cancer: analysis and reporting on a Canadian population-based study
Research Team
- Marie-Elise Parent, INRS (Principal Investigator)
- Paul Demers, Occupational Cancer Research Center
- Jérôme Lavoué, Université de Montréal
- Marie-Claude Rousseau, INRS
- Andrea Benedetti, McGill University
- Cheryl Peters, Alberta Health Services
Rationale: Each year, 21,000 Canadian men are diagnosed with prostate cancer (PCa). About 30% of these are aggressive but diagnosis and treatment of non-aggressive ones seriously impact quality of life. Age, ancestry and family history are the only established risk factors while genetics explain only a proportion of familial cases. There is compelling evidence that environmental factors play a role, but modifiable risk factors have yet to be identified so prevention has not been possible. Other than for pesticides, very little research has been conducted on environmental chemicals in PCa etiology. Several chemicals are themselves carcinogens or act as hormone modulators, and could be implicated. The workplace represents a preferential window to study these since many are encountered there at higher levels, facilitating their measurement. Since most workplace chemicals eventually make their way into the general environment, such exposures are not only relevant to workers but also to the entire population. The absence of large occupational studies benefiting from strong exposure assessment has been the major drawback to advancing knowledge in this area. In 2002-2015, Canadian funding agencies funded what is to our knowledge the largest and most comprehensive population-based study of PCa, to assess the etiological role of workplace exposures. The occupational assessment was completed, as planned, in late 2015, coinciding with the end of funding, and it was anticipated that new funding would need to be secured for primary analyses.
Broad goal: To investigate whether different exposures measured in the workplace increase the risk of developing PCa.
Methods: 1,933 cases, including 538 aggressive cancers, were ascertained from Montreal metropolitan area hospitals. Concomitantly, 1,994 population controls were selected from electoral lists. Face-to-face interviews collected information on socio-demographic, lifestyle and medical factors, including screening. We documented each job held by each subject over his lifetime, eliciting details on specific tasks, equipment used, etc. This wealth of occupational information (15,724 job descriptions) has been coded by a team of chemists/industrial hygienists into lifetime exposure to hundreds of chemicals.
Aims: This protocol outlines 19 analytical subprojects to be undertaken over the course of the grant. It focuses on suspected exposures with hormone-modulating properties and/or previous evidence such as polycyclic aromatic hydrocarbons, petroleum-derived liquids, engine emissions and combustion products, solvents, welding fumes, resins and polymers, metals, painting-related chemicals, and pesticides. Other projects focus on night work and on physical activity/inactivity at work. Exposures will be analysed individually and combined, taking into account co-exposures, confounding and interactions.
Significance/application: This project, representing a major advance in the field, will generate important new knowledge towards the establishment of preventive measures against PCa.
Publications
ROUSSEAU M.-C., CONUS F., EL-ZEIN M., BENEDETTI A., PARENT M.-É (2023)
Ascertaining asthma in epidemiologic studies: a comparison between administrative health data and self-report
BMC Medical Research Methodology In Press
FANTODJI C.*, JANTCHOU P., PARENT M.-É., ROUSSEAU M.-C. (2022)
Appendectomy and risk for inflammatory bowel disease: effect of age and time post-appendectomy, a cohort study
BMJ Open Gastroenterology 9(1):e000925
MÉSIDOR M., ROUSSEAU M.-C., O’LOUGHLIN J., SYLVESTRE M.-P. (2022)
Does group-based trajectory modeling estimate spurious trajectories?
BMC Medical Research Methodology 22(1):194
PÉPIN J., FOX A., LEBLANC L.,DE WALS P., ROUSSEAU M.-C. (2022)
In the footsteps of Albert Calmette: an ecological study of tuberculosis, leprosy, and production of raw milk as a proxy for exposure to wild-type Mycobacterium bovis.
Transactions of the Royal Society of Tropical Medicine and Hygiene 116(12):1112-1122
CORSENAC P., PARENT M.-É., MANSARAY H., BENEDETTI A., RICHARD H., STÄGER S., ROUSSEAU, M.-C. (2022)
Early life Bacillus Calmette-Guerin vaccination and incidence of type 1, type 2, and latent autoimmune diabetes in adulthood.
Diabetes & Metabolism 48(3):101337
MADATHIL S.A., ROUSSEAU M.-C., DURÁN D., ALLI B., JOSEPH L., NICOLAU B. (2022)
Life course tobacco smoking and risk of HPV-negative oral cancers in two countries.
Frontiers Oral Health 3:844230
CORSENAC P., PARENT M.-É., WOLFSON C., ARBOUR N., DUQUETTE P., BENEDETTI A., RICHARD H., STÄGER S., ROUSSEAU, M.-C. (2022)
Bacillus Calmette-Guerin vaccination and multiple sclerosis: a population-based birth cohort study in Quebec, Canada.
European Journal of Neurology 29(6):1791-1804
CORSENAC P., PARENT M.-É., BENEDETTI A., RICHARD H., STÄGER S., ROUSSEAU M.-C. (2022)
Association between Bacillus Calmette-Guerin vaccination and type 1 diabetes in adolescence: a population-based birth cohort study in Quebec, Canada.
Preventive Medicine 154:106893
PÉPIN J., LABBÉ A.-C., CARIGNAN A., PARENT M.-É., YU J., GRENIER C., BEAUCHEMIN S., DE WALS P., VALIQUETTE L., ROUSSEAU, M.-C. (2021)
Does BCG provide long-term protection against SARS-CoV-2 infection? a case-control study in the province of Quebec, Canada.
Vaccine. 39(50):7300-7307
PÉPIN J., DE WALS P., LABBÉ A.-C., CARIGNAN A., PARENT M.-É., YU J., VALIQUETTE L., ROUSSEAU, M.-C. (2021)
Influenza vaccine during the 2019-2020 season and COVID-19 risk: a case-control study in Quebec.
Canada Communicable Disease Report. 47(10):430-434
MÉSIDOR M., ROUSSEAU M.-C., DUQUETTE P., SYLVESTRE M.-P. (2021)
Classification and visualization of longitudinal patterns of medication dose: an application to interferon-beta-1a and amitriptyline in patients with multiple sclerosis.
Pharmacoepidemiology and Drug Safety. 30(9):1214-1223
MÉSIDOR M., SYLVESTRE M.-P., ROUSSEAU M.-C., ROGER E., DUQUETTE P. (2021)
A non-parametric propensity score for estimating the effect of interferon-beta or glatiramer acetate on long-term outcomes of multiple sclerosis.
Multiple Sclerosis and Related Disorders. 53:103050
MÉSIDOR M., SYLVESTRE M.-P., MARRIE R.A., ROUSSEAU M.-C. (2020)
Does age at diagnosis influence the use of health services for multiple sclerosis?
Multiple Sclerosis and Related Disorders. 46:102555
TRUDEAU K., ROUSSEAU M.-C., BARUL C., CSIZMADI I., PARENT M.-É. (2020)
Dietary patterns are associated with risk of prostate cancer in a population-based case-control study in Montreal, Canada,
Nutrients. 12(7):1907
ALLI B.Y., BURK R.D., FATAHZADEH M., KAZIMIROFF J., GROSSBERG R.M., SMITH R.V., OW T.J., WILTZ M., POLANCO J., ROUSSEAU M.-C., NICOLAU B., SCHLECHT N.F. (2020)
HIV modifies the effect of tobacco smoking on oral human papillomavirus infection,
Journal of Infectious Diseases. 222(14):646-654
SALMON C., CONUS F., PARENT M.-É., BENEDETTI A., ROUSSEAU M.-C. (2020)
Association between Bacillus Calmette-Guerin (BCG) vaccination and lymphoma risk: a systematic review and meta-analysis,
Cancer Epidemiology. 65(2020):101696
TRUDEAU K., ROUSSEAU M.-C., PARENT M.-É. (2020)
Extent of food processing and risk of prostate cancer: the PROtEuS study in Montreal, Canada,
Nutrients. 12(3):637
BEAUD H., ALBERT O., ROBAIRE B., ROUSSEAU M.-C., CHAN P.T., DELBES G. (2019)
Sperm DNA integrity in adult survivors of paediatric leukemia and lymphoma: a pilot study on the impact of age and type of treatment,
PLOS One. 14(12):e0226262
MADATHIL S., ROUSSEAU M.-C., JOSEPH L., COUTLÉE F., CASTONGUAY G., FRANCO E., NICOLAU B. (2020)
Latency of tobacco smoking for head and neck cancer among HPV-positive and HPV-negative individuals,
International Journal of Cancer. 147(1):56-64
SALMON C., CONUS F., PARENT M.-É., BENEDETTI A., ROUSSEAU M.-C. (2019)
Association between Bacillus Calmette-Guérin vaccination and lymphoma: a population-based birth cohort study,
Journal of Internal Medicine. 286(5):583-595
HONG Q.N., PLUYE P., FÀBREGUES S., BARTLETT G., BOARDMAN F., CARGO M., DAGENAIS P., GAGNON M.-P., GRIFFITHS F., NICOLAU B., O’CATHAIN A., ROUSSEAU M.-C., VEDEL I. (2019)
Improving the content validity of the Mixed Methods Appraisal Tool (MMAT): a modified e-Delphi study,
Journal of Clinical Epidemiology. 111(7):49-59
TRUDEAU K., ROUSSEAU M.-C., CSIZMADI I., PARENT M.-É. (2019)
Dietary patterns among French-speaking men residing in Montreal, Canada,
Preventive Medicine Reports. 13:205-213
HONG Q.N., FÀBREGUES S., BARTLETT G., BOARDMAN F., CARGO M., DAGENAIS P., GAGNON M.-P., GRIFFITHS F., NICOLAU B., O’CATHAIN A., ROUSSEAU M.-C., VEDEL I., PLUYE P. (2018)
The Mixed Methods Appraisal Tool (MMAT) version 2018 for information professionals and researchers,
Education for Information. 34(4):285-291
LAPRISE C., MADATHIL S.A., SCHLECHT N.F., CASTONGUAY G., SOULIÈRES D., NGUYEN-TAN P.F., ALLISON P., COUTLÉE F., HIER M., ROUSSEAU M.-C., FRANCO E.L., NICOLAU B. (2019)
Increased risk of oropharyngeal cancers is mediated by oral human papillomavirus infection: data from Canadian population,
Head & Neck. 41(3):678-685
MÉSIDOR M., BENEDETTI A., EL-ZEIN M., MENZIES R, PARENT M.-E., ROUSSEAU M.-C. (2019)
Asthma phenotypes based on health services utilization for allergic diseases in a province-wide birth cohort,
Annals of Allergy, Asthma & Immunology. 122(1): 50-57
NICOLAU B., MADATHIL S., CASTONGUAY G., PARENT M.-E., ROUSSEAU M.-C., SIEMIATYCKI J. (2019)
Shared social mechanisms underlying the risk of nine cancers: a life course study,
International Journal of Cancer. 144(1):59-67
PARENT M.-E., RICHARD H., ROUSSEAU M.-C., TRUDEAU K. (2018)
Vitamin C Intake and Risk of Prostate Cancer: the Montreal PROtEuS Study,
Frontiers in Physiology. 9:1218
SAUVÉ J.-F., SIEMIATYCKI J., LABRÈCHE F., RICHARDSON L., PINTOS J., SYLVESTRE M.-P., GÉRIN M., BÉGIN D., LACOURT A., KIRKHAM T.L., RÉMEN T., PASQUET R., GOLDBERG M.S., ROUSSEAU M.-C., PARENT M.-É., LAVOUÉ J. (2018)
Development of and selected performance characteristics of CANJEM, a general population job exposure matrix based on past expert assessments of exposure,
Annals of Work Exposures and Health. 62(7):783-795
MADATHIL S., JOSEPH L., HARDY R., ROUSSEAU M.-C., NICOLAU B. (2018)
A Bayesian approach to investigate life-course hypotheses involving continuous exposures,
International Journal of Epidemiology. 47(5):1623-1635
ROUSSEAU M.-C., EL-ZEIN M., CONUS F., BENEDETTI A., PARENT M.-É. (2018)
Cohort Profile: The Québec Birth Cohort on Immunity and Health (QBCIH),
International Journal of Epidemiology. 47(4):1040-1041h
XU M., SIEMIATYCKI J., LAVOUÉ J., PASQUET R., PINTOS J., ROUSSEAU M.-C., RICHARDSON L., HO V. (2018)
Occupational exposures to leaded and unleaded gasoline engine emissions and lung cancer risk,
Occupational and Environmental Medicine. 75(4):303-309
BLANC-LAPIERRE A., ROUSSEAU M.-C., PARENT M.-É. (2017)
Perceived workplace stress is associated with an increased risk of prostate cancer before age 65,
Frontiers Oncology. 7;269
KÂ K., ROUSSEAU M.‐C., TRAN S.D., HENDERSON M., NICOLAU B. (2018)
Association between metabolic syndrome and gingival inflammation in obese children,
International Journal of Dental Hygiene. 16(3):397-403
FARSI N.J., ROUSSEAU M.-C., SCHLECHT N., CASTONGUAY G., ALLISON P., NGUYEN-TAN P.F., SOULIÈRES D., COUTLÉE F., HIER M., MADATHIL S., FRANCO E.L., NICOLAU B. (2017)
Aetiological Heterogeneity of Head and Neck Squamous Cell Carcinomas: The Role of Human Papillomavirus Infections, Smoking, and Alcohol,
Carcinogenesis. 38(12):1188-1195
ROUSSEAU M.-C., CONUS F., KÂ K., EL-ZEIN M., PARENT M.-E., MENZIES D. (2017)
Bacillus Calmette-Guérin (BCG) vaccination patterns in the province of Québec, Canada (1956-1974),
Vaccine. 35:4777-4784
DA ROSA P., EDASSARI A., ROUSSEAU M.-C., NICOLAU B. (2017)
Investigating socioeconomic position in dental caries and traumatic dental injury among children in Quebec,
Community Dental Health. 34(4):226-233
LAPRISE C., MADATHIL S.A., SCHLECHT N.F., CASTONGUAY G., SOULIÈRES D., NGUYEN-TAN P.F., ALLISON P., COUTLÉE F., HIER M., ROUSSEAU M.-C., FRANCO E.L., NICOLAU B. (2017)
Human papillomavirus genotypes and risk of head and neck cancers: results from the HeNCe life case-control study,
Oral Oncology. 69:56-61
SHARECK M., ROUSSEAU M.-C., KOUSHIK A., SIEMIATYCKI J., PARENT M.-É. (2017)
Inverse association between dietary intake of selected carotenoids and vitamin C and risk of lung cancer,
Frontiers in Oncology. 7(23)
EL-ZEIN M., CONUS F., BENEDETTI A., MENZIES R., PARENT M.-É., ROUSSEAU M.-C. (2017)
Association between Bacillus Calmette-Guérin (BCG) vaccination and childhood asthma in the Québec Birth Cohort on Immunity and Health,
American Journal of Epidemiology. 186(3):344-355
BLANC-LAPIERRE A., ROUSSEAU M.-C., WEISS D., EL-ZEIN M., SIEMIATYCKI J., PARENT M.-É. (2016)
Lifetime report of perceived stress at work and cancer among men: a case-control study in Montreal, Canada,
Preventive Medicine. 96:28-35
MADATHIL S.A., ROUSSEAU M.-C., WYNANT W., SCHLECHT N., PURAKKAL A.S.T., NETUVELI G., NICOLAU B. (2016)
Nonlinear association between betel quid chewing and oral cancer: Implications for prevention,
Oral Oncology. 60:25-31
LAPRISE C., PUTHIYANNAL S.H.K., MATHADIL S.A., THEKKEPURAKKAL A.S., CASTONGUAY G., VARGHESE I., SHIRAZ S., SCHLECHT N.F., ROUSSEAU M.-C., FRANCO E.L., NICOLAU B. (2016)
Periodontal diseases and risk of oral cancer in Southern India: Results from the HeNCe Life study,
International Journal of Cancer. 139(7):1512-9
SHAW E., RAMANAKUMAR A.V., EL-ZEIN M., SILVA F.R., GALAN L., BAGGIO M.L., VILLA L.L., FRANCO E.L.; LUDWIG-MCGILL COHORT STUDY GROUP. (2016)
Reproductive and genital health and risk of cervical human papillomavirus infection: results from the Ludwig-McGill cohort study,
BMC Infectious Disease. 16:116
LAPRISE C., MATHADIL S.A., ALLISON P., ABRAHAM P., RAGHAVENDRAN A., PURAKKAL A.S.T., CASTONGUAY G., COUTLÉE F., SCHLECHT N., ROUSSEAU M.-C., FRANCO E.L., NICOLAU B. (2016)
No role for human papillomavirus infection in oral cancers in a region in Southern India,
International Journal of Cancer. 138(4)912-7
ROUSSEAU, M. C., EL-ZEIN, M., CONUS, F., LEGAULT, L. & PARENT, M. E. (2016)
Bacillus Calmette-Guerin (BCG) Vaccination in Infancy and Risk of Childhood Diabetes,
Paediatric and Perinatal Epidemiology. 30(2):141-8
EL-ZEIN, M., CONUS, F., BENEDETTI, A., PARENT, M. E. & ROUSSEAU, M. C. (2016)
Evaluating the validity of a two-stage sample in a birth cohort established from administrative databases,
Epidemiology.27(1):105-15
FARSI, N. J., EL-ZEIN, M., GAIED, H., LEE, Y. C., HASHIBE, M., NICOLAU, B. & ROUSSEAU, M. C. (2015)
Sexual behaviours and head and neck cancer: A systematic review and meta-analysis
Cancer Epidemiol.39(6):1036-46
CHRISTENSEN, K. Y., LAVOUÉ, J., ROUSSEAU, M. C. & SIEMIATYCKI, J. (2015)
Lack of a protective effect of cotton dust on risk of lung cancer: evidence from two population-based case-control studies,
BMC Cancer, 15, 212.
MADATHIL, S. A., ROUSSEAU, M. C., ALLISON, P., NETUVELI, G., HUMPHRIS, G. M., VARGHESE, I., SHIRAZ, S., CASTONGUAY, G., THEKKEPURAKKAL, A. S., SHAHUL, H. P. & NICOLAU, B. (2015)
Maternal and paternal contribution to intergenerational psychosocial transmission of paan chewing,
Community Dentistry and Oral Epidemiology, 43, 4, 289-297.
WEISS, D., EL-ZEIN, M., ROUSSEAU, M. C., RICHARD, H., KARAKIEWICZ, P. I. & PARENT, M. E. (2014)
Asthma, allergy and the risk of prostate cancer: Results from the Montreal PROtEuS study,
Cancer Epidemiology, 38, 6, 695-699.
SPENCE, A. R., ROUSSEAU, M. C., KARAKIEWICZ, P. I. & PARENT, M. E. (2014)
Circumcision and prostate cancer: a population-based case-control study in Montreal, Canada
BJU International, 114, 6b, E90-8.
ROUSSEAU, M. C., PARENT, M. E., MENZIES, D., BENEDETTI, A., CONUS, F. & EL-ZEIN, M. (2014)
PD45 – BCG vaccination and childhood asthma: preliminary results from the Quebec Birth Cohort on Immunity and Health,
Clin Transl Allergy, 4, Suppl 1 3rd Pediatric Allergy and Asthma Meeting (PAAM)Publi, P45.
LI, J., MENZIES, D., LANDRY, J. S., BENEDETTI, A. & ROUSSEAU, M. C. (2014)
Determinants of Bacillus Calmette-Guerin (BCG) vaccination among Quebec children,
Preventive Medicine, 66C, 87-94.
KÂ, K., ROUSSEAU, M. C., TRAN, S. D., KAARTINEN, M. T., MYNENI, V. D., HENDERSON, M. & NICOLAU, B. (2014)
Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour necrosis factor-α in children
Journal of Clinical Periodontology, 41, 5, 467-472.
ROUSSEAU, M.-C., CONUS, F., LI, J., PARENT, M.-E. & EL-ZEIN, M. (2014)
The Quebec BCG Vaccination Registry (1956-1992): assessing data quality and linkage with administrative health databases,
BMC Medical Informatics and Decision Making, 14, 1, 2.
EL-ZEIN, M., PARENT, M. E., SIEMIATYCKI, J. & ROUSSEAU, M. C. (2014)
History of allergic diseases and lung cancer risk,
Annals of Allergy, Asthma, and Immunology, 112, 3, 230-6.
SPENCE, A. R., ROUSSEAU, M. C. & PARENT, M. E. (2014)
Sexual partners, sexually transmitted infections, and prostate cancer risk,
Cancer epidemiology, 38, 6, 700-7.
KÂ, K., ROUSSEAU, M. C., LAMBERT, M., O’LOUGHLIN, J., HENDERSON, M., TREMBLAY, A., ALOS, N. & NICOLAU, B. (2013)
Association between lean and fat mass and indicators of bone health in prepubertal caucasian children,
Hormone Research in Paediatrics, 80, 3, 154-162.
KÂ, K., ROUSSEAU, M. C., LAMBERT, M., TREMBLAY, A., TRAN, S. D., HENDERSON, M. & NICOLAU, B. (2013)
Metabolic syndrome and gingival inflammation in Caucasian children with a family history of obesity
Journal of Clinical Periodontology, 40, 11, 986-993.
WYNANT, W., SIEMIATYCKI, J., PARENT, M.-É. & ROUSSEAU, M.-C. (2013)
Occupational exposure to lead and lung cancer: results from two case-control studies in Montreal, Canada,
Occupational and Environmental Medicine, 70, 3, 164-70.
PARENT, M. E., EL-ZEIN, M., ROUSSEAU, M. C., PINTOS, J. & SIEMIATYCKI, J. (2013)
RE: “NIGHT WORK AND THE RISK OF CANCER AMONG MEN” REPLY,
American Journal of Epidemiology, 177, 10, 1166-1167.
MAHBOUBI, A., KOUSHIK, A., SIEMIATYCKI, J., LAVOUE, J. & ROUSSEAU, M. C. (2013)
Assessment of the effect of occupational exposure to formaldehyde on the risk of lung cancer in two Canadian population-based case-control studies,
Scandinavian Journal of Work, Environment and Health, 39, 4, 401-10.
EL-ZEIN, M., PARENT, M. É. & ROUSSEAU, M. C. (2013)
Comments on a recent meta-analysis: Obesity and lung cancer,
International Journal of Cancer, 132, 8, 1962-1963.
EL-ZEIN, M., PARENT, M. E., NICOLAU, B., KOUSHIK, A., SIEMIATYCKI, J. & ROUSSEAU, M. C. (2013)
Body mass index, lifetime smoking intensity, and lung cancer risk,
International Journal of Cancer, 133, 7, 1721-1731.
PARENT, M. É., EL-ZEIN, M., ROUSSEAU, M. C., PINTOS, J. & SIEMIATYCKI, J. (2012)
Night Work and the Risk of Cancer Among Men,
American Journal of Epidemiology, 176, 9, 751-759
PARENT, M. É., EL-ZEIN, M., ROUSSEAU, M. C., PINTOS, J. & SIEMIATYCKI, J. (2012)
Parent et Al. Respond to “shift work and cancer”,
American Journal of Epidemiology, 176, 9, 764-5.
MATUKALA NKOSI, T., PARENT, M. É., SIEMIATYCKI, J. & ROUSSEAU, M. C. (2012)
Socioeconomic Position and Lung Cancer Risk: How Important is the Modeling of Smoking?,
Epidemiology, 23, 3, 377-85.
PARENT, M. É., ROUSSEAU, M. C., EL-ZEIN, M., LATREILLE, B., DÉSY, M. & SIEMIATYCKI, J. (2011)
Occupational and recreational physical activity during adult life and the risk of cancer among men
Cancer Epidemiology , 35, 2, 151-159.
NKOSI, T. M., PARENT, M. É., SIEMIATYCKI, J., PINTOS, J. & ROUSSEAU, M. C. (2011)
Comparison of indicators of material circumstances in the context of an epidemiological study
BMC Medical Research Methodology , 11, 108.
EL-ZEIN, M., PARENT, M. É. & ROUSSEAU, M. C. (2011)
Comments on a recent meta-analysis: BCG vaccination and allergic conditions
Journal of Allergy and Clinical Immunology , 127, 4, 1081.
DA ROSA, P., NICOLAU, B., BRODEUR, J. M., BENIGERI, M., BEDOS, C. & ROUSSEAU, M. C. (2011)
Associations between school deprivation indices and oral health status
Community Dentistry and Oral Epidemiology , 39, 3, 213-220.
EL-ZEIN, M., PARENT, M. E., KA, K., SIEMIATYCKI, J., ST-PIERRE, Y. & ROUSSEAU, M. C. (2010)
History of asthma or eczema and cancer risk among men: a population-based case-control study in Montreal, Quebec, Canada
Annals of Allergy, Asthma, and Immunology , 104, 5, 378-84.
EL-ZEIN, M., PARENT, M. E., BENEDETTI, A. & ROUSSEAU, M. C. (2010)
Does BCG vaccination protect against the development of childhood asthma? A systematic review and meta-analysis of epidemiological studies
International Journal of Epidemiology , 39, 2, 469-86.
PINTOS, J., PARENT, M. E., CASE, B. W., ROUSSEAU, M. C. & SIEMIATYCKI, J. (2009)
Risk of mesothelioma and occupational exposure to asbestos and man-made vitreous fibers: evidence from two case-control studies in Montreal, Canada
Journal of Occupational and Environmental Medicine , 51, 10, 1177-84.
KA, K., ROUSSEAU, M. C. & NICOLAU, B. (2009)
Supportive periodontal care for patients with chronic periodontitis may produce better clinical outcomes when delivered by a specialist instead of a general practitioner, but at a higher cost
Journal of Evidence-Based Dental Practice , 9, 4, 231-3.
ROUSSEAU, M.-C., PARENT, M.-E., NADON, L., LATREILLE, B. & SIEMIATYCKI, J. (2008)
THE AUTHORS REPLY– RE: “Occupational exposure to lead compounds and risk of cancer among men: A population-based case-control study”.
American Journal of Epidemiology , 168, 10, 1217-1218.
ROUSSEAU, M. C., PARENT, M. É. & ST-PIERRE, Y. (2008)
Potential health effects from non-specific stimulation of the immune function in early age: The example of BCG vaccination
Pediatric Allergy and Immunology , 19, 5, 438-448.
PINTOS, J., PARENT, M. E., ROUSSEAU, M. C., CASE, B. W. & SIEMIATYCKI, J. (2008)
Occupational exposure to asbestos and man-made vitreous fibers, and risk of lung cancer: evidence from two case-control studies in Montreal, Canada
Journal of Occupational and Environmental Medicine , 50, 11, 1273-81.
NICOLAU, B. & ROUSSEAU, M. C. (2008)
Association of height with inflammation and periodontitis: the study of health in Pomerania
J Evid Based Dent Pract , 8, 2, 95-6.
ROUSSEAU, M. C., PARENT, M. É., NADON, L., LATREILLE, B. & SIEMIATYCKI, J. (2007)
Occupational exposure to lead compounds and risk of cancer among men: A population-based case-control study
American Journal of Epidemiology , 166, 9, 1005-1014.
PARENT, M. É., ROUSSEAU, M. C., BOFFETTA, P., COHEN, A. & SIEMIATYCKI, J. (2007)
Exposure to diesel and gasoline engine emissions and the risk of lung cancer
American Journal of Epidemiology , 165, 1, 53-62.
ROUSSEAU, M. C., PARENT, M. É., POLLAK, M. N. & SIEMIATYCKI, J. (2006)
Diabetes mellitus and cancer risk in a population-based case-control study among men from Montreal, Canada
International Journal of Cancer , 118, 8, 2105-9.
STRAIF, K., CARDIS, E., BOFFETTA, P., ROUSSEAU, M. C. & SIEMIATYCKI, J. (2005)
ELF MFs: Straif et al. respond
Environmental Health Perspectives , 113, 11, A727-A727.
ROUSSEAU, M. C., STRAIF, K. & SIEMIATYCKI, J. (2005)
IARC carcinogen update
Environmental Health Perspectives , 113, 9, A580-1.
ROUSSEAU, M. C., PARENT, M. É. & SIEMIATYCKI, J. (2005)
Comparison of self-reported height and weight by cancer type among men from Montreal, Canada
European Journal of Cancer Prevention , 14, 5, 431-8.
SIEMIATYCKI, J., RICHARDSON, L., STRAIF, K., LATREILLE, B., LAKHANI, R., CAMPBELL, S., ROUSSEAU, M. C. & BOFFETTA, P. (2004)
Listing occupational carcinogens
Environmental Health Perspectives , 112, 15, 1447-1459.
ROUSSEAU, M. C., VILLA, L. L., COSTA, M. C., ABRAHAMOWICZ, M., ROHAN, T. E. & FRANCO, E. (2003)
Occurrence of cervical infection with multiple human papillomavirus types is associated with age and cytologic abnormalities
Sexually Transmitted Diseases , 30, 7, 581-7.
ROUSSEAU, M. C. & FRANCO, E. L. (2003)
Détection des infections à HPV. In: AUBIN, F., PRETET, J. L. & MOUGIN, C. (Eds.)
Papillomavirus humains : biologie et pathologie tumorale. Paris. , Les Éditions Médicales Internationales, 758p.
ROUSSEAU, M. C., ABRAHAMOWICZ, M., VILLA, L. L., COSTA, M. C., ROHAN, T. E. & FRANCO, E. L. (2003)
Predictors of cervical coinfection with multiple human papillomavirus types
Cancer Epidemiology, Biomarkers and Prevention , 12, 10, 1029-37.
LI, J., ROUSSEAU, M. C., FRANCO, E. L. & FERENCZY, A. (2003)
Is colposcopy warranted in women with external anogenital warts?
Journal of Lower Genital Tract Disease , 7, 1, 22-8.
ROUSSEAU, M. C., PEREIRA, J. S., PRADO, J. C., VILLA, L. L., ROHAN, T. E. & FRANCO, E. L. (2001)
Cervical coinfection with human papillomavirus (HPV) types as a predictor of acquisition and persistence of HPV infection
Journal of Infectious Diseases , 184, 12, 1508-17.
ROUSSEAU, M. C., FRANCO, E. L., VILLA, L. L., SOBRINHO, J. P., TERMINI, L., PRADO, J. M. & ROHAN, T. E. (2000)
A cumulative case-control study of risk factor profiles for oncogenic and nononcogenic cervical human papillomavirus infections
Cancer Epidemiology, Biomarkers and Prevention , 9, 5, 469-76.
FRANCO, E. L., VILLA, L. L., SOBRINHO, J. P., PRADO, J. M., ROUSSEAU, M. C., DESY, M. & ROHAN, T. E. (1999)
Epidemiology of acquisition and clearance of cervical human papillomavirus infection in women from a high-risk area for cervical cancer
Journal of Infectious Diseases , 180, 5, 1415-23.