Marie-Claude Rousseau

Professeur INRS

Areas of expertise

Asthma, diabetes, multiple sclerosis, inflammatory bowel disease, cancer , Chronic disease epidemiology , Diabetes , Inflammatory bowel disease , Multiple sclerosis

  • INRS Professor

Phone
450 687-5010

Fax
450 686-5501

E-mail
marie-claude.rousseau@iaf.inrs.ca

Armand-Frappier Santé Biotechnologie Research Centre

531, boulevard des Prairies
Laval (Québec)  H7V 1B7
CANADA

See research centre

Dr. Marie-Claude Rousseau obtained a bachelor’s degree (B.Sc.) in biochemistry from Université du Québec a Montréal in 1991. Her graduate studies were conducted at McGill University, where she earned a M.Sc. (1998) and Ph.D. (2003) in Epidemiology & Biostatistics.

With a postdoctoral fellowship from the National Cancer Institute of Canada, she joined Dr Jack Siemiatycki ‘s research chair in Environmental Epidemiology and Population Health at Université de Montréal’s Department of social and preventive medicine (2003-2004). In 2005, she joined INRS-Institut Armand-Frappier as a Professor.

Her research activities, funded by the Canadian Institutes for Health Research (CIHR), the Canadian Cancer Society, the Multiple Sclerosis Society of Canada, and the Fonds de recherche du Québec – Santé (FRQS), consist in epidemiological studies on the etiology of inflammatory and autoimmune diseases (asthma, diabetes, multiple sclerosis, inflammatory bowel disease, and cancer).

Her work focuses on three main themes related to these diseases:

  • the study of factors influencing the immune response and their role in etiology
  • the study of lifestyle and environmental exposures as potential risk or protective factors
  • the evaluation of health services utilization

Studying inflammatory bowel disease etiology: a life course approach

Collaborators :                                                                            

Prévost  Jantchou, CHU Sainte-Justine, co-principal investigator

Andrea Benedetti, McGill University

Sylvie Girard, CHU Sainte-Justine

Sreenath Madathil, McGill University

Belinda Nicolau, McGill University

Shu Qin Wei, CHU Sainte-Justine

 

Funding/partnership :

Canadian Institutes of Health Research (2018-2022)

Institut de la statistique du Québec (2019-2020)

 

Inflammatory bowel disease is a chronic disease of the gut. It affects digestion and absorption of food, and elimination of waste. Its causes are unknown. After many studies, researchers have only been able to identify a few risk factors with certainty. They include family history of the disease and cigarette smoking. The causes of this disease are still unknown, but some researchers think that certain times in life could be more critical for the development of the disease.

 

Our goal is to clarify the causes of disease, and identify which ones could be targeted by prevention program. We are studying medical, environmental, lifestyle, and psychosocial factors from the time of birth until adult years to determine if they are linked to the development of the disease. These factors are for example: prematurity, breastfeeding, antibiotic use, diet, smoking, stress. We also study carefully when these factors occur during a person’s life. For this research, we are using a cohort of about 400,000 persons born between 1970 and 1974, in the province of Quebec. We created this cohort by linking together some provincial administrative databases. Data on medical services and hospitalizations for inflammatory bowel disease were obtained until 2014 and have been used to determine who is affected by the disease. We will ask about 2600 persons of the cohort to complete a web survey to collect information on the factors of interest. Among the participants, we will compare persons who have the disease to those who do not, and evaluate what are the key moments throughout their lives when these factors could affect the risk of the disease.

 

This research will help understanding which factors increase the risk of inflammatory bowel disease by detecting if there are certain times in a person’s life that are especially important for etiology. This will allow us to generate crucial information to establish prevention programs.

 

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Potential health effects from non-specific stimulation of the immune system in early age through vaccination with Bacille Calmette-Guérin (BCG)

 

Project on lymphoma

Collaborators:

Andrea Benedetti, McGill University

Marie-Élise Parent, INRS

 

Funding:

Canadian Cancer Society (2015-2018)

 

Project on Multiple Sclerosis

Collaborators: 

Christina Wolfson, McGill University

Andrea Benedetti, McGill University

Nathalie Arbour, CHUM, Université de Montréal

Pierre Duquette, CHUM, Université de Montréal

Marie-Élise Parent, INRS

 

Funding:

Multiple Sclerosis Society of Canada (2015-2018)

Canadian Institutes of Health Research (2015-2016)

 

Several studies have suggested a possible link between vaccination, childhood infections and the development of the immune system. The BCG vaccine stimulates macrophages, which in turn induce the production of cytokines by TH1 lymphocytes. Epidemiological results on the health effects of BCG vaccination are contradictory. Some studies have suggested a decreased incidence of asthma, allergies, and type-1 diabetes among vaccinated individuals. The BCG vaccine has been suggested as a potential preventive factor against leukemia and melanoma, but as a risk factor for non-Hodgkin’s lymphoma and Hodgkin’s disease.

A BCG vaccination program took place in Quebec from 1949 to 1974, initiated by Dr Armand Frappier himself. The vaccination certificates for the entire province were sent to the central registry, still kept at Centre Armand-Frappier Santé Biotechnologie within INRS. The registry was computerized through a grant from the Canada Foundation for Innovation (Leaders Opportunity Fund). The overall objective of these projects is to determine whether a non-specific stimulation of the immune system in early life, as resulting from BCG vaccination, is associated with beneficial or adverse health effects. The BCG vaccination registry is a unique resource with enormous potential to answer questions about the potential off-target effects of this vaccine. We have demonstrated the feasibility and validity of linking this data source to administrative databases available in Quebec [birth and death registries, Med-Écho (hospitalizations), RAMQ (medical services)].

 

Our current work will open the door to studies focusing on the link between immunity, infections, and several chronic diseases. The information acquired thereof will go way beyond the BCG vaccination itself. It has the potential to provide leads into a better understanding of the role of immunostimulation early in life and of mechanistic processes involved in the development of chronic diseases characterized by an inflammatory or autoimmune process.

 

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Workplace exposures and prostate cancer: analysis and reporting on a Canadian population-based study

Collaborators:

Marie-Elise Parent, INRS, Principal Investigator

Paul Demers, Occupational Cancer Research Center

Jérôme Lavoué, Université de Montréal

Marie-Claude Rousseau, INRS

Andrea Benedetti, McGill University

Cheryl Peters, Alberta Health Services

 

Funding:

Canadian Institutes of Health Research (2018-2022)

 

Rationale: Each year, 21,000 Canadian men are diagnosed with prostate cancer (PCa). About 30% of these are aggressive but diagnosis and treatment of non-aggressive ones seriously impact quality of life. Age, ancestry and family history are the only established risk factors while genetics explain only a proportion of familial cases. There is compelling evidence that environmental factors play a role, but modifiable risk factors have yet to be identified so prevention has not been possible. Other than for pesticides, very little research has been conducted on environmental chemicals in PCa etiology. Several chemicals are themselves carcinogens or act as hormone modulators, and could be implicated. The workplace represents a preferential window to study these since many are encountered there at higher levels, facilitating their measurement. Since most workplace chemicals eventually make their way into the general environment, such exposures are not only relevant to workers but also to the entire population. The absence of large occupational studies benefiting from strong exposure assessment has been the major drawback to advancing knowledge in this area. In 2002-2015, Canadian funding agencies funded what is to our knowledge the largest and most comprehensive population-based study of PCa, to assess the etiological role of workplace exposures. The occupational assessment was completed, as planned, in late 2015, coinciding with the end of funding, and it was anticipated that new funding would need to be secured for primary analyses.

 

Broad goal: To investigate whether different exposures measured in the workplace increase the risk of developing PCa.

 

Methods: 1,933 cases, including 538 aggressive cancers, were ascertained from Montreal metropolitan area hospitals. Concomitantly, 1,994 population controls were selected from electoral lists. Face-to-face interviews collected information on socio-demographic, lifestyle and medical factors, including screening. We documented each job held by each subject over his lifetime, eliciting details on specific tasks, equipment used, etc. This wealth of occupational information (15,724 job descriptions) has been coded by a team of chemists/industrial hygienists into lifetime exposure to hundreds of chemicals.

 

Aims: This protocol outlines 19 analytical subprojects to be undertaken over the course of the grant. It focuses on suspected exposures with hormone-modulating properties and/or previous evidence such as polycyclic aromatic hydrocarbons, petroleum-derived liquids, engine emissions and combustion products, solvents, welding fumes, resins and polymers, metals, painting-related chemicals, and pesticides. Other projects focus on night work and on physical activity/inactivity at work. Exposures will be analysed individually and combined, taking into account co-exposures, confounding and interactions.

 

Significance/application: This project, representing a major advance in the field, will generate important new knowledge towards the establishment of preventive measures against PCa.

Publications

ROUSSEAU, M. C., EL-ZEIN, M., CONUS, F., LEGAULT, L. & PARENT, M. E. (2015)
Bacillus Calmette-Guerin (BCG) Vaccination in Infancy and Risk of Childhood Diabetes,
Paediatric and Perinatal Epidemiology.

 

EL-ZEIN, M., CONUS, F., BENEDETTI, A., PARENT, M. E. & ROUSSEAU, M. C. (2015)
Evaluating the validity of a two-stage sample in a birth cohort established from administrative databases,
Epidemiology.

 

FARSI, N. J., EL-ZEIN, M., GAIED, H., LEE, Y. C., HASHIBE, M., NICOLAU, B. & ROUSSEAU, M. C. (2015)
Sexual behaviours and head and neck cancer: A systematic review and meta-analysis,
Cancer Epidemiol.

 

CHRISTENSEN, K. Y., LAVOUÉ, J., ROUSSEAU, M. C. & SIEMIATYCKI, J. (2015)
Lack of a protective effect of cotton dust on risk of lung cancer: evidence from two population-based case-control studies,
BMC Cancer, 15, 212.

 

MADATHIL, S. A., ROUSSEAU, M. C., ALLISON, P., NETUVELI, G., HUMPHRIS, G. M., VARGHESE, I., SHIRAZ, S., CASTONGUAY, G., THEKKEPURAKKAL, A. S., SHAHUL, H. P. & NICOLAU, B. (2015)
Maternal and paternal contribution to intergenerational psychosocial transmission of paan chewing,
Community Dentistry and Oral Epidemiology, 43, 4, 289-297.

 

WEISS, D., EL-ZEIN, M., ROUSSEAU, M. C., RICHARD, H., KARAKIEWICZ, P. I. & PARENT, M. E. (2014)
Asthma, allergy and the risk of prostate cancer: Results from the Montreal PROtEuS study,
Cancer Epidemiology, 38, 6, 695-699.

 

SPENCE, A. R., ROUSSEAU, M. C., KARAKIEWICZ, P. I. & PARENT, M. E. (2014)
Circumcision and prostate cancer: a population-based case-control study in Montreal, Canada,
BJU International, 114, 6b, E90-8.

 

ROUSSEAU, M. C., PARENT, M. E., MENZIES, D., BENEDETTI, A., CONUS, F. & EL-ZEIN, M. (2014)
PD45 – BCG vaccination and childhood asthma: preliminary results from the Quebec Birth Cohort on Immunity and Health,
Clin Transl Allergy, 4, Suppl 1 3rd Pediatric Allergy and Asthma Meeting (PAAM)Publi, P45.

 

LI, J., MENZIES, D., LANDRY, J. S., BENEDETTI, A. & ROUSSEAU, M. C. (2014)
Determinants of Bacillus Calmette-Guerin (BCG) vaccination among Quebec children,
Preventive Medicine, 66C, 87-94.

 

KÂ, K., ROUSSEAU, M. C., TRAN, S. D., KAARTINEN, M. T., MYNENI, V. D., HENDERSON, M. & NICOLAU, B. (2014)
Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour necrosis
factor-α in children
,

Journal of Clinical Periodontology, 41, 5, 467-472.

 

ROUSSEAU, M.-C., CONUS, F., LI, J., PARENT, M.-E. & EL-ZEIN, M. (2014)
The Quebec BCG Vaccination Registry (1956-1992): assessing data quality and linkage with administrative health databases,
BMC Medical Informatics and Decision Making, 14, 1, 2.

 

EL-ZEIN, M., PARENT, M. E., SIEMIATYCKI, J. & ROUSSEAU, M. C. (2014)
History of allergic diseases and lung cancer risk,
Annals of Allergy, Asthma, and Immunology, 112, 3, 230-6.

 

SPENCE, A. R., ROUSSEAU, M. C. & PARENT, M. E. (2014)
Sexual partners, sexually transmitted infections, and prostate cancer risk,
Cancer epidemiology, 38, 6, 700-7.

 

KÂ, K., ROUSSEAU, M. C., LAMBERT, M., O’LOUGHLIN, J., HENDERSON, M., TREMBLAY, A., ALOS, N. & NICOLAU, B. (2013)
Association between lean and fat mass and indicators of bone health in prepubertal caucasian children,
Hormone Research in Paediatrics, 80, 3, 154-162.

 

KÂ, K., ROUSSEAU, M. C., LAMBERT, M., TREMBLAY, A., TRAN, S. D., HENDERSON, M. & NICOLAU, B. (2013)
Metabolic syndrome and gingival inflammation in Caucasian children with a family history of obesity,
Journal of Clinical Periodontology, 40, 11, 986-993.

 

WYNANT, W., SIEMIATYCKI, J., PARENT, M.-É. & ROUSSEAU, M.-C. (2013)
Occupational exposure to lead and lung cancer: results from two case-control studies in Montreal, Canada,
Occupational and Environmental Medicine, 70, 3, 164-70.

 

PARENT, M. E., EL-ZEIN, M., ROUSSEAU, M. C., PINTOS, J. & SIEMIATYCKI, J. (2013)
RE: “NIGHT WORK AND THE RISK OF CANCER AMONG MEN” REPLY,
American Journal of Epidemiology, 177, 10, 1166-1167.

 

MAHBOUBI, A., KOUSHIK, A., SIEMIATYCKI, J., LAVOUE, J. & ROUSSEAU, M. C. (2013)
Assessment of the effect of occupational exposure to formaldehyde on the risk of lung cancer in two Canadian population-based case-control studies,
Scandinavian Journal of Work, Environment and Health, 39, 4, 401-10.

 

EL-ZEIN, M., PARENT, M. É. & ROUSSEAU, M. C. (2013)
Comments on a recent meta-analysis: Obesity and lung cancer,
International Journal of Cancer, 132, 8, 1962-1963.

 

EL-ZEIN, M., PARENT, M. E., NICOLAU, B., KOUSHIK, A., SIEMIATYCKI, J. & ROUSSEAU, M. C. (2013)
Body mass index, lifetime smoking intensity, and lung cancer risk,
International Journal of Cancer, 133, 7, 1721-1731.

 

PARENT, M. É., EL-ZEIN, M., ROUSSEAU, M. C., PINTOS, J. & SIEMIATYCKI, J. (2012)
Night Work and the Risk of Cancer Among Men,
American Journal of Epidemiology, 176, 9, 751-759

 

PARENT, M. É., EL-ZEIN, M., ROUSSEAU, M. C., PINTOS, J. & SIEMIATYCKI, J. (2012)
Parent et Al. Respond to “shift work and cancer”,
American Journal of Epidemiology, 176, 9, 764-5.

 

MATUKALA NKOSI, T., PARENT, M. É., SIEMIATYCKI, J. & ROUSSEAU, M. C. (2012)
Socioeconomic Position and Lung Cancer Risk: How Important is the Modeling of Smoking?,
Epidemiology, 23, 3, 377-85.

 

PARENT, M. É., ROUSSEAU, M. C., EL-ZEIN, M., LATREILLE, B., DÉSY, M. & SIEMIATYCKI, J. (2011)
Occupational and recreational physical activity during adult life and the risk of cancer among men
Cancer Epidemiology , 35, 2, 151-159.

 

NKOSI, T. M., PARENT, M. É., SIEMIATYCKI, J., PINTOS, J. & ROUSSEAU, M. C. (2011)
Comparison of indicators of material circumstances in the context of an epidemiological study
BMC Medical Research Methodology , 11, 108.

 

EL-ZEIN, M., PARENT, M. É. & ROUSSEAU, M. C. (2011)
Comments on a recent meta-analysis: BCG vaccination and allergic conditions
Journal of Allergy and Clinical Immunology , 127, 4, 1081.

 

DA ROSA, P., NICOLAU, B., BRODEUR, J. M., BENIGERI, M., BEDOS, C. & ROUSSEAU, M. C. (2011)
Associations between school deprivation indices and oral health status
Community Dentistry and Oral Epidemiology , 39, 3, 213-220.

 

EL-ZEIN, M., PARENT, M. E., KA, K., SIEMIATYCKI, J., ST-PIERRE, Y. & ROUSSEAU, M. C. (2010)
History of asthma or eczema and cancer risk among men: a population-based case-control study in Montreal, Quebec, Canada
Annals of Allergy, Asthma, and Immunology , 104, 5, 378-84.

 

EL-ZEIN, M., PARENT, M. E., BENEDETTI, A. & ROUSSEAU, M. C. (2010)
Does BCG vaccination protect against the development of childhood asthma? A systematic review and meta-analysis of epidemiological studies
International Journal of Epidemiology , 39, 2, 469-86.

 

PINTOS, J., PARENT, M. E., CASE, B. W., ROUSSEAU, M. C. & SIEMIATYCKI, J. (2009)
Risk of mesothelioma and occupational exposure to asbestos and man-made vitreous fibers: evidence from two case-control studies in Montreal, Canada
Journal of Occupational and Environmental Medicine , 51, 10, 1177-84.

 

KA, K., ROUSSEAU, M. C. & NICOLAU, B. (2009)
Supportive periodontal care for patients with chronic periodontitis may produce better clinical outcomes when delivered by a specialist instead of a general practitioner, but at a higher cost
Journal of Evidence-Based Dental Practice , 9, 4, 231-3.

 

ROUSSEAU, M.-C., PARENT, M.-E., NADON, L., LATREILLE, B. & SIEMIATYCKI, J. (2008)
THE AUTHORS REPLY– RE: “Occupational exposure to lead compounds and risk of cancer among men: A population-based case-control study”.
American Journal of Epidemiology , 168, 10, 1217-1218.

 

ROUSSEAU, M. C., PARENT, M. É. & ST-PIERRE, Y. (2008)
Potential health effects from non-specific stimulation of the immune function in early age: The example of BCG vaccination
Pediatric Allergy and Immunology , 19, 5, 438-448.

 

PINTOS, J., PARENT, M. E., ROUSSEAU, M. C., CASE, B. W. & SIEMIATYCKI, J. (2008)
Occupational exposure to asbestos and man-made vitreous fibers, and risk of lung cancer: evidence from two case-control studies in Montreal, Canada
Journal of Occupational and Environmental Medicine , 50, 11, 1273-81.

 

NICOLAU, B. & ROUSSEAU, M. C. (2008)
Association of height with inflammation and periodontitis: the study of health in Pomerania
J Evid Based Dent Pract , 8, 2, 95-6.

 

ROUSSEAU, M. C., PARENT, M. É., NADON, L., LATREILLE, B. & SIEMIATYCKI, J. (2007)
Occupational exposure to lead compounds and risk of cancer among men: A population-based case-control study
American Journal of Epidemiology , 166, 9, 1005-1014.

 

PARENT, M. É., ROUSSEAU, M. C., BOFFETTA, P., COHEN, A. & SIEMIATYCKI, J. (2007)
Exposure to diesel and gasoline engine emissions and the risk of lung cancer
American Journal of Epidemiology , 165, 1, 53-62.

 

ROUSSEAU, M. C., PARENT, M. É., POLLAK, M. N. & SIEMIATYCKI, J. (2006)
Diabetes mellitus and cancer risk in a population-based case-control study among men from Montreal, Canada
International Journal of Cancer , 118, 8, 2105-9.

 

STRAIF, K., CARDIS, E., BOFFETTA, P., ROUSSEAU, M. C. & SIEMIATYCKI, J. (2005)
ELF MFs: Straif et al. respond
Environmental Health Perspectives , 113, 11, A727-A727.

 

ROUSSEAU, M. C., STRAIF, K. & SIEMIATYCKI, J. (2005)
IARC carcinogen update
Environmental Health Perspectives , 113, 9, A580-1.

 

ROUSSEAU, M. C., PARENT, M. É. & SIEMIATYCKI, J. (2005)
Comparison of self-reported height and weight by cancer type among men from Montreal, Canada
European Journal of Cancer Prevention , 14, 5, 431-8.

 

SIEMIATYCKI, J., RICHARDSON, L., STRAIF, K., LATREILLE, B., LAKHANI, R., CAMPBELL, S., ROUSSEAU, M. C. & BOFFETTA, P. (2004)
Listing occupational carcinogens
Environmental Health Perspectives , 112, 15, 1447-1459.

 

ROUSSEAU, M. C., VILLA, L. L., COSTA, M. C., ABRAHAMOWICZ, M., ROHAN, T. E. & FRANCO, E. (2003)
Occurrence of cervical infection with multiple human papillomavirus types is associated with age and cytologic abnormalities
Sexually Transmitted Diseases , 30, 7, 581-7.

 

ROUSSEAU, M. C. & FRANCO, E. L. (2003)
Détection des infections à HPV. In: AUBIN, F., PRETET, J. L. & MOUGIN, C. (Eds.)
Papillomavirus humains : biologie et pathologie tumorale. Paris. , Les Éditions Médicales Internationales, 758p.

 

ROUSSEAU, M. C., ABRAHAMOWICZ, M., VILLA, L. L., COSTA, M. C., ROHAN, T. E. & FRANCO, E. L. (2003)
Predictors of cervical coinfection with multiple human papillomavirus types
Cancer Epidemiology, Biomarkers and Prevention , 12, 10, 1029-37.

 

LI, J., ROUSSEAU, M. C., FRANCO, E. L. & FERENCZY, A. (2003)
Is colposcopy warranted in women with external anogenital warts?
Journal of Lower Genital Tract Disease , 7, 1, 22-8.

 

ROUSSEAU, M. C., PEREIRA, J. S., PRADO, J. C., VILLA, L. L., ROHAN, T. E. & FRANCO, E. L. (2001)
Cervical coinfection with human papillomavirus (HPV) types as a predictor of acquisition and persistence of HPV infection
Journal of Infectious Diseases , 184, 12, 1508-17.

 

ROUSSEAU, M. C., FRANCO, E. L., VILLA, L. L., SOBRINHO, J. P., TERMINI, L., PRADO, J. M. & ROHAN, T. E. (2000)
A cumulative case-control study of risk factor profiles for oncogenic and nononcogenic cervical human papillomavirus infections
Cancer Epidemiology, Biomarkers and Prevention , 9, 5, 469-76.

 

FRANCO, E. L., VILLA, L. L., SOBRINHO, J. P., PRADO, J. M., ROUSSEAU, M. C., DESY, M. & ROHAN, T. E. (1999)
Epidemiology of acquisition and clearance of cervical human papillomavirus infection in women from a high-risk area for cervical cancer
Journal of Infectious Diseases , 180, 5, 1415-23.