July 28, 2016
( update : September 15, 2020 )
Professor Albert Descoteaux of INRS–Institut Armand-Frappier Research Centre and his team have discovered novel virulence strategies employed by the Leishmania parasite. These scientific breakthroughs recently published in the prestigious PLoS Pathogens journal represent two important clues to understanding the cellular and molecular mechanisms governing the parasitic infections that cause leishmaniasis, a neglected tropical disease endemic in one hundred countries.
“Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression” presents the results of research carried out by Pierre-André Casgrain (master’s student), Caroline Martel, W. Robert McMaster, Jeremy C. Mottram, Martin Olivier, and Albert Descoteaux. The researchers received financial support from the Canadian Institutes of Health Research, the Medical Research Council, and the Centre for Host-Parasite Interactions. doi:10.1371/journal.ppat.1005658
“Leishmania major Promastigotes Evade LC3-Associated Phagocytosis through the Action of GP63” was written by Christine Matte (research assistant), Pierre-André Casgrain (master’s student), Olivier Séguin (doctoral student), Neda Moradin (doctoral student), Wan Jin Hong, and Albert Descoteaux. The Canadian Institutes of Health Research and the Centre for Host-Parasite Interactions funded this research.