Valérie Langlois

Areas of expertise

Ecotoxicogenomics , Animal physiology , Chemical and environmental toxicology , Endocrine disruption , Endocrinology , Molecular biology




Eau Terre Environnement Research Centre

490 rue de la Couronne
Québec City, Quebec  G1K 9A9

See research centre


Adams, Julie E.; Madison, Barry N.; Charbonneau, Kelli; Sereneo, Marie; Baillon, Lucie; Langlois, Valérie S.; Brown, Stephen R. et Hodson, Peter V. (2020). Effects on trout alevins of chronic exposures to chemically-dispersed Access Western Blend and Cold Lake Blend dilbitsEnviron. Toxicol. Chem., EN LIGNE.
DOI : 10.1002/etc.4747

Dominique, Mélanie; Letcher, Robert J.; Rutter, Allison et Langlois, Valérie S. (2020). Comparative review of the distribution and burden of contaminants in the body of polar bearsEnviron. Sci. Pollut. Res., EN LIGNE.
DOI : 10.1007/s11356-020-09193-2

Robitaille, Julie et Langlois, Valérie S. (2020). Consequences of steroid-5a-reductase deficiency and inhibition in vertebratesGen. Comp. Endocr., 290 (Mai) : Art. 13400.
DOI : 10.1016/j.ygcen.2020.113400

Trudeau, Vance L.; Thompson, Paisley E; Zhang, Wo Su; Reynaud, Stephane; Navarro-Martin, Laia et Langlois, Valérie S. (2020). Agrochemicals disrupt multiple endocrine axes in amphibiansMol. Cell. Endocrino., 513 (Août) : Art. 110861.
DOI : 10.1016/j.mce.2020.110861

Wallace, Sarah J.; Leclerc, A. J. A.; Prosser, R. S.; de Solla, Shane R.; Balakrishnan, V. K. et Langlois, Valérie S. (2020). Sub-lethal effects of calcium dinonylnaphthalenesulfonate on Western clawed frog embryosComp. Biochem. Physiol. (D) Genom. Proteom., 34 (Juin) : Art. 100658.
DOI : 10.1016/j.cbd.2020.100658

Beirao, Jose; Baillon, Lucie; Litt, Margaret A.; Langlois, Valérie S. et Purchase, Craig F. (2019). Impact of crude oil and the dispersant CorexitTM EC9500A on capelin (Mallotus villosus) embryo developmentMar. Environ. Res., 147 (Mai) : 90-100.
DOI : 10.1016/j.marenvres.2019.04.004

Castaneda Cortes, Diana C.; Arias Padilla, Luisa F.; Langlois, Valérie S.; Somoza, Gustavo M. et Fernandino, Juan I. (2019). The central nervous system acts as a transducer of stress-induced masculinization through corticotropin-releasing hormone BDevelopment, 146 (8) : Art. dev172866.
DOI : 10.1242/dev.172866

Lara-Jacobo, Linda Ramona; Williard, Brianna; Wallace, Sarah J. et Langlois, Valérie S. (2019). Cytochrome P450 1A transcript is a suitable biomarker of both exposure and response to diluted bitumen in developing frog embryosEnviron. Pollut., 246 (Mars) : 501-508.
DOI : 10.1016/j.envpol.2018.12.039

McDonnell, Denby; Barry, Madison N.; Baillon, Lucie; Wallace, Sarah J.; Brown, Stephen R.; Hodson, Peter V. et Langlois, Valérie S. (2019). Comparative toxicity of two diluted bitumens to developing yellow perch (Perca flavescens)Sci. Total Environ., 655 (Mars) : 977-985.
DOI : 10.1016/j.scitotenv.2018.11.199

Zhang, Jing; Knight, Rosalinda; Wang, Yushan; Sawyer, Thomas W.; Martyniuk, Christopher J. et Langlois, Valérie S. (2019). Hair follicle miRNAs: a novel biomarker for primary blast induced-mild traumatic brain injuryBiomarkers, 24 (2) : 166-179.
DOI : 10.1080/1354750X.2018.1531929

Alsaadi, Ftoon; Hodson, Peter V. et Langlois, Valérie S. (2018). An embryonic field of study: The aquatic fate and toxicity of diluted bitumenBull. Env. Contam. Toxicol., 100 (1) : 8-13.
DOI : 10.1007/s00128-017-2239-7

Alsaadi, Ftoon; Madison, Barry N.; Brown, R. S.; Hodson, P. V. et Langlois, Valérie S. (2018). Morphological and molecular effects of two diluted bitumens on developing fathead minnow (Pimephales promelas)Aquat. Toxicol., 204 (Novembre) : 107-116.
DOI : 10.1016/j.aquatox.2018.09.003

Bissegger, Sonja; Castro, Marco A. Pineda; Yargeau, Viviane et Langlois, Valérie S. (2018). Phthalates modulate steroid 5-reductase transcripts in the Western clawed frog embryoComp. Biochem. Physiol. (C), 213 (Novembre) : 39-46.
DOI : 10.1016/j.cbpc.2018.07.005

Campbell, Diana E. K. et Langlois, Valérie S. (2018). Expression of sf1 and dax-1 are regulated by thyroid hormones and androgens during Silurana tropicalis early developmentGen. Comp. Endocr., 259 (Avril) : 34-44.
DOI : 10.1016/j.ygcen.2017.10.017

Campbell, Diana E. K. et Langlois, Valérie S. (2018). Thyroid hormones and androgens differentially regulate gene expression in testes and ovaries of sexually mature Silurana tropicalisGen. Comp. Endocr., 267 (Octobre) : 172-182.
DOI : 10.1016/j.ygcen.2018.07.001

Campbell, Diana E. K.; Montgomerie, Robert D. et Langlois, Valérie S. (2018). Lifecycle exposure to perchlorate differentially alters morphology, biochemistry, and transcription as well as sperm motility in Silurana tropicalis frogsEnviron. Pollut., 237 (Juin) : 196-204.
DOI : 10.1016/j.envpol.2018.02.038

Thompson, Paisley et Langlois, Valérie S. (2018). Developmental profiles of progesterone receptor transcripts and molecular responses to gestagen exposure during Silurana tropicalis early developmentGen. Comp. Endocr., 265 (Septembre) : 4-14.
DOI : 10.1016/j.ygcen.2018.05.017

Wallace, S. J.; de Solla, S. R.; Thomas, P. J.; Harner, T.; Eng, A. et Langlois, Valérie S. (2018). Airborne polycyclic aromatic compounds contribute to the induction of the tumour-suppressing P53 pathway in wild double-crested cormorantsEcotox. Environ. Safe., 150 (Avril) : 176-189.
DOI : 10.1016/j.ecoenv.2017.12.028


Publications jusqu’en 2016

Le nom des étudiants dirigés par la professeure Valérie Langlois sont en gras. Tous les autres sont des collaborateurs universitaires (canadiens1 et internationaux2) ou gouvernementaux3.

Mathieu-Denoncourt J, Martyniuk CJ2, Yargeau V1, de Solla SR3 et VS Langlois (2016). Lethal and sublethal effects of phthalate diesters on Silurana tropicalis larvae. Environ Toxicol Chem, 35(10): 2511-2522.

DOI: 10.1002/etc.3413

Crump D3, Farhat A3, Chiu S3, Williams KL3, Jones SP3 et VS Langlois (2016). Use of a novel double-crested cormorant ToxChip PCR array and the EROD assay to determine effects of environmental contaminants in primary hepatocytes. Environ Sci Technol, 50(6): 3265-3274.

DOI: 10.1021/acs.est.5b06181

Gibson L, Caumette G1, Button M 1, Koch I1, Reimer KJ1, Cullen WR 1 et VS Langlois (2016). Life cycle exposure of the frog Silurana tropicalis to arsenate: Steroid- and thyroid hormone-related genes are differently altered throughout development. Gen Comp Endocrinol, 234:133-141.

DOI: 10.1016/j.ygcen.2015.09.015

Balakrishnan VK3, Shirin S3, Aman AM3, de Solla SR3, Mathieu-Denoncourt J et VS Langlois (2016). Genotoxic and carcinogenic products arising from reductive transformations of the azo dye, Disperse Yellow 7. Chemosphere, 146: 206-215.

DOI: 10.1016/j.chemosphere.2015.11.119

Zhang J, Koch I1, Gibson LA, Loughery JR1, Martyniuk CJ2, Button M1, Caumette G1, Reimer KJ1, Cullen WR 1 et VS Langlois (2015). Transcriptomic responses during early development following arsenic exposure in Western clawed frogs, Silurana tropicalis. Tox Sci 148(2):603-17.

DOI: 10.1093/toxsci/kfv207

Madison BN, Hodson PV1 et VS Langlois (2015). Diluted bitumen causes deformities and molecular responses indicative of oxidative stress in Japanese medaka embryos. Aq Tox, 165:222-230.

DOI: 10.1016/j.aquatox.2015.06.006

Koch I1, Zhang J, Button M1, Gibson L, Caumette G1, Langlois VS, Reimer KJ1 et WR Cullen1 (2015). Arsenic(+3) and DNA methyltransferases and arsenic speciation in tadpole and frog life stages of Western Clawed frogs (Silurana tropicalis) exposed to arsenate. Metallomics, 7(8):1274-1284.

DOI: 10.1039/c5mt00078e

Mathieu-Denoncourt J, de Solla SR3 et VS Langlois (2015). Chronic exposure to monomethyl phthalate alters metamorphosis and sex ratio in Western clawed frogs. Gen Comp Endocrinol, 219: 53-63.

DOI: 10.1016/j.ygcen.2015.01.019

Mathieu-Denoncourt J, de Solla SR3 et VS Langlois (2015). Plasticizer endocrine disruption: Highlighting developmental and reproductive effects in mammals and non-mammalian aquatic species. Gen Comp Endocrinol, 219: 74-88.

DOI: 10.1016/j.ygcen.2014.11.003

Castañeda DC, Langlois VS et JI Fernandino (2014). Crossover of the hypothalamic pituitary-adrenal/interrenal (HPA), -thyroid (HPT), and -gonadal (HPG) axes in testicular development. Frontiers Endocrinol, 5:139.

DOI: 10.3389/fendo.2014.00139

Zhang J, Carnduff LNorman G, Josey T3, Wang Y3, Sawyer T3 Martyniuk CJ1 et VS Langlois (2014). Transcriptional profiling in rat hair follicles following simulated blast insult: A new diagnostic tool for traumatic brain injuryPLoS ONE, 9(8): e104518.

DOI: 10.1371/journal.pone.0104518

Flood D et VS Langlois (2014). Crosstalk between androgen and thyroid hormones during amphibian early development. Gen Comp Endocrinol, 203: 232-240.

DOI: 10.1016/j.ygcen.2014.03.037

Bissegger S, Martyniuk CJ1 et VS Langlois (2014). Transcriptomic response of finasteride in male frog gonads using an ex vivo approachGen Comp Endocrinol, 203:137-145.

DOI: 10.1016/j.ygcen.2014.01.018

Gibson LA, Lavoie RA1Bissegger S, Campbell LM 1 et VS Langlois (2014). A positive correlation between mercury and oxidative stress-related gene expression (GPX3 and GSTM3) is measured in female Double-crested Cormorant bloodEcotoxicol, 23(6): 1004-1014.

DOI: 10.1007/s10646-014-1243-5

Mathieu-Denoncourt J, Martyniuk CJ1, de Solla SR3, Balakrishnan  VK3 et VS Langlois (2014). Sediment contaminated with the azo dye Disperse Yellow 7 alters cellular stress- and androgen-related transcription in Silurana tropicalis larvaeEnviron Science Technol, 48(5): 2952-2961.

DOI: 10.1021/es500263x

Soriano JJ, Mathieu-Denoncourt JNorman G, de Solla SR3 et VS Langlois (2014).  Effects of Acid Red 97 and Bismack Brown Y in frog larvae developmentEnviron Sci Pollut Res, 21(5): 3582-3591.

DOI: 10.1007/s11356-013-2323-4

Martyniuk CJ1, Bissegger S et VS Langlois (2014). Current perspectives on the androgen 5 alpha-dihydrotestosterone (DHT) and 5 alpha-reductases in teleost fishes and amphibiansGen Comp Endocrinol, 194: 264-274.

DOI: 10.1016/j.ygcen.2014.06.011

Flood DEK, Fernandino JI2 et VS Langlois (2013). Thyroid hormones in male reproductive  development: Evidence for direct crosstalk between the androgen and thyroid hormone axesGen Comp Endocrinol, 192: 2-14.

DOI: 10.1016/j.ygcen.2013.02.038

Langlois VS et CJ Martyniuk(2013). Genome wide analysis of Silurana (Xenopus) tropicalis development reveals dynamic expression using network enrichment analysisMech Dev, 130: 304-322.

DOI: 10.1016/j.mod.2012.12.002

Denyes MJ, Langlois VS, Rutter A1 et BA Zeeb1 (2012). The use of biochar to reduce soil PCB bioavailability to Cucurbita pepo and Eisenia fetida. Sci Total Environ, 437: 76-82.

DOI: 10.1016/j.scitotenv.2012.07.081

Hayes TB2, DeSolla S3, Iguchi T2, Ingraham H2, Kestemont P2,  Kniewald J2, Kniewald Z2, Langlois VS, Luque EH2, Muñoz-de-Toro M2, Oka T2, Oliveira CA2, Suzawa M2, Tillit D2, Trudeau VL1, Victor-Costa1 AB et E Willingham2 (2011). Demasculinization and feminization of male gonads by atrazine: Consistent effects across vertebrate classes. J Steroid Biochem Mol Biol, 127: 64-73.

DOI: 10.1016/j.jsbmb.2011.03.015

Langlois VS, Rutter A1 et BA Zeeb1 (2011). Activated carbon immobilizes residual polychlorinated biphenyls (PCBs) at contaminated terrestrial sites. J Environ Qual, 40: 1130-1134.


Langlois VS, Duarte-Guterman P1 et VL Trudeau1 (2011). Expression profiles of reproduction- and thyroid-related transcripts in the brains of chemically-induced intersex frogs. Sex Dev, 5: 26-32.

DOI: 10.1159/000322875

Mennigen JA1, Lado WE1, Zamora JM1, Duarte-Guterman P1, Langlois VS, Metcalfe CD1, Chang JP1, Moon TW1 et VL Trudeau1 (2010). Fluoxetine disrupts the reproductive axis in sexually mature male goldfish, Carassius auratus. Aquat Toxicol, 100: 354-364.

DOI: 10.1016/j.aquatox.2010.08.016

Langlois VS, Zhang D1, Cooke GM3 et VL Trudeau1 (2010). Evolution of steroid 5-alpha-reductases and a comparison of their function with 5-beta-reducdtase. Gen Comp Endocrinol, 166: 489-497.

DOI: 10.1016/j.ygcen.2009.08.004

Langlois VS, Carew AC, Pauli BD3, Wade MG3, Cooke GM3 et VL Trudeau1 (2010). Low levels of the herbicide atrazine disrupt Rana pipiens gonadal development and metamorphosis in outdoor mesocosms. Environ Health Perspect, 118: 552-557.

DOI: 10.1289/ehp.0901418

Langlois VS, Duarte-Guterman P1, Ing S, Pauli BD3, Cooke GM3 et VL Trudeau1 (2010). Fadrozole and finasteride exposures modulate sex steroid- and thyroid-related gene expression in Silurana (Xenopus) tropicalis early larval development. Gen Comp Endocrinol, 166: 417-427.

DOI: 10.1016/j.ygcen.2009.11.004

Zhang D1, Duarte-Guterman P1, Langlois VS et VL Trudeau1 (2010) Temporal expression and steroidal regulation of piRNA pathway genes (mael, piwi, vasa) during Silurana (Xenopus) tropicalis embryogenesis and early larval developmentComp Biochem Physiol C Tox Pharmacol ,152: 202-206.


Duarte-Guterman P1, Langlois VS, Pauli BD3 et VL Trudeau1 (2010). Expression and T3 regulation of thyroid- and sex steroid-related genes during Silurana (Xenopus) tropicalis early development. Gen Comp Endocrinol, 166: 428-435.

DOI: 10.1016/j.ygcen.2009.12.008