Back to top

Valérie Langlois

Areas of expertise

Ecotoxicogenomics , Animal physiology , Chemical and environmental toxicology , Endocrine disruption , Endocrinology , Molecular biology

Eau Terre Environnement Research Centre

490 de la Couronne Street
Québec City, Quebec  G1K 9A9

See the research centre

Research interests

The focus of Professor Langlois work is on the harmful effects on vertebrates of chemicals present in aquatic environments. These substances can potentially affect all stages of cellular regulation in aquatic vertebrates, from hormone synthesis to target cell responses, and consequently they can alter the metabolism, development, and reproduction of vertebrates, and even their biodiversity.

The main theme of her research program is the identification of physiological responses and regulatory mechanisms in vertebrates exposed to environmental contaminants and vertebrate tracking using environmental DNA. For more than 15 years, her team has been working with academic and government partners to determine the harmful effects of these contaminants on vertebrates.

The main research axes are:

  • Axis 1: Metabolism of polycyclic aromatic hydrocarbons in aquatic species
  • Axis 2: Emerging pollutants and their impact on the development of aquatic species
  • Axis 3: Endocrine disruptors in aquatic species
  • Axis 4: Environmental DNA to track species in healthy and polluted environments


Barton-Maclaren, Tara S., Wade, Michael G., Basu, Niladri, Bayen, Stéphane, Grundy, J., Marlatt, Vicki, Moore, R., Parent, L., Parrott, Joanne L., Grigorova, P., Pinsonnault-Cooper, J. & Langlois, Valérie S. (2022). Innovation in regulatory approaches for endocrine disrupting chemicals: The journey to risk assessment modernization in Canada. Environ. Res., 204 (Part C): Art. 112225.
DOI: 10.1016/j.envres.2021.112225

Robitaille, Julie, Denslow, Nancy D., Escher, Beate I., Kurita-Oyamada, Hajime G., Marlatt, Vicki, Martyniuk, Christopher J., Navarro-Martin, Laia, Prosser, Ryan, Sanderson, Thomas, Yargeau, Viviane & Langlois, Valérie S. (2022). Towards regulation of Endocrine Disrupting chemicals (EDCs) in water resources using bioassays – A guide to developing a testing strategy. Environ. Res., 205: Art. 112483.
DOI: 10.1016/j.envres.2021.112483

Bérubé, Roxanne, Lefebvre-Raine, Molly, Gauthier, Charles, Bourdin, Thibault, Bellot, Pauline, Triffault-Bouchet, Gaëlle, Langlois, Valérie S. & Couture, Patrice (2021). Comparative toxicity of conventional and unconventional oils during rainbow trout (Oncorhynchus mykiss) embryonic development: From molecular to health consequencesChemosphere, 288 (Part 2): Art. 132521.
DOI: 10.1016/j.chemosphere.2021.132521

Bérubé, Roxanne, Gauthier, Charles, Bourdin, Thibault, Bouffard, Marilou, Triffault-Bouchet, Gaëlle, Langlois, Valérie S. & Couture, Patrice (2021). Lethal and sublethal effects of diluted bitumen and conventional oil on fathead minnow (Pimephales promelas) larvae exposed during their early developmentAquat. Toxicol., 237: Art. 105884.
DOI: 10.1016/j.aquatox.2021.105884

Colson, Tash-Lynn L.; de Solla, Shane R. & Langlois, Valérie S. (2021). Bioaccumulation and physiological responses of the turtle Chelydra serpentina exposed to polychlorinated biphenyls during early life stagesChemosphere, 263: Art. 128146.
DOI: 10.1016/j.chemosphere.2020.128146

Empey, Madelaine A., Lefebvre-Raine, Molly, Gutierrez-Villagomez, Juan Manuel, Langlois, Valérie S. & Trudeau, Vance L. (2021). A review of the effects of the biopesticides Bacillus thuringiensis serotypes israelensis (Bti) and kurstaki (Btk) in amphibiansArch. Environ. Con. Toxicol., 80 (4): 789-800.
DOI: 10.1007/s00244-021-00842-2

Gutierrez-Villagomez, Juan Manuel, Patey, Géraldine, To, Tuan Anh, Lefebvre-Raine, Molly, Lara-Jacobo, Linda Ramona, Comte, Jérôme, Klein, Bert & Langlois, Valérie S. (2021). Frogs respond to commercial formulations of the biopesticide Bacillus thuringiensis var. israelensis, especially their intestine microbiotaEnviron. Sci. Technol., 55 (18): 12504-12516.
DOI: 10.1021/acs.est.1c02322

Langlois, Valérie S. (2021). Amphibian toxicology: A rich but underappreciated model for ecotoxicology research. Arch. Environ. Con. Toxicol., 80: 661-662.

Langlois, Valérie S.; Allison, Michael J.; Bergman, Lauren C.; To, Tuan Anh & Helbing, Caren C. (2020). The need for robust qPCR-based eDNA detection assays in environmental monitoring and species inventoriesEnviron. DNA, 3 (3): 519-527.
DOI: 10.1002/edn3.164

Lara-Jacobo, Linda Ramona; Gauthier, Charles; Xin, Qin; Dupont, Félix; Couture, Patrice; Triffault-Bouchet, Gaëlle; Dettman, Heather & Langlois, Valérie S. (2021). Fate and fathead minnow embryotoxicity of weathering crude oil in a pilot-scale spill tankEnviron. Toxicol. Chem., 40 (1): 127-138.
DOI: 10.1002/etc.4891

Lebordais, Marc, Gutierrez-Villagomez, Juan Manuel, Gigault, Julien, Baudrimont, Magalie & Langlois, Valérie S. (2021). Molecular impacts of dietary exposure to nanoplastics combined with arsenic in Canadian oysters (Crassostrea virginica) and bioaccumulation comparison with Caribbean oysters (Isognomon alatus)Chemosphere, 277: Art. 130331.
DOI: 10.1016/j.chemosphere.2021.130331

Lebordais, Marc; Venel, Zélie; Gigault, Julien; Langlois, Valérie S. & Baudrimont, Magalie (2021). Molecular impacts of dietary exposure to nanoplastics combined or not with arsenic in the Caribbean mangrove oysters (Isognomon alatus). Nanomaterials, 11 (5): Art. 1151.

Lefebvre-Raine, Molly; Paquet, N.; Triffault-Bouchet, Gaëlle & Langlois, Valérie S. (2021). Embryotoxicity of five cytostatics in fathead minnow (Pimephales promelas) larvaeBull. Env. Contam. Toxicol., 106: 747-752.
DOI: 10.1007/s00128-021-03146-2

Lin, Feng, Baillon, Lucie, Langlois, Valérie S. & Kennedy, Christopher J. (2021). Environmental modulators of diluted bitumen effects in juvenile pink salmon (Oncorhynchus gorbuscha)Mar. Environ. Res., 169: Art. 105392.
DOI: 10.1016/j.marenvres.2021.105392

Schiano Di Lombo, Magali, Weeks-Santos, Shannon, Clérandeau, Christelle, Triffault-Bouchet, Gaëlle, Langlois, Valérie S., Couture, Patrice & Cachot, Jérôme (2021). Comparative developmental toxicity of conventional oils and diluted bitumen on early life stages of the rainbow trout (Oncorhynchus mykiss)Aquat. Toxicol., 239: Art. 105937.
DOI: 10.1016/j.aquatox.2021.105937

Thambirajah, Anita A., Wade, Michael G., Verreault, Jonathan, Buisine, Nicolas, Alves, Veronica A., Langlois, Valérie S. & Helbing, Caren C. (2021). Disruption by stealth-Interference of endocrine disrupting chemicals on hormonal crosstalk with thyroid axis function in humans and other animalsEnviron. Res., 203: Art. 111906.
DOI: 10.1016/j.envres.2021.111906

Thomson, Paisley E., Pineda, Marco, Yargeau, Viviane & Langlois, Valérie S. (2021). Chronic exposure to two gestagens differentially alters morphology and gene expression in Silurana tropicalisArch. Environ. Con. Toxicol., 80 (4): 745-759.
DOI: 10.1007/s00244-021-00831-5

Adams, Julie E.; Madison, Barry N.; Charbonneau, Kelli; Sereneo, Marie; Baillon, Lucie; Langlois, Valérie S.; Brown, Stephen R. & Hodson, Peter V. (2020). Effects on trout alevins of chronic exposures to chemically-dispersed Access Western Blend and Cold Lake Blend dilbits. Environ. Toxicol. Chem., 39 (8): 1620-1633.
DOI: 10.1002/etc.4747

Castaneda Cortes, Diana C.; Zhang, Jing; Boan, Augustin F.; Langlois, Valérie S. & Fernandino, Juan I. (2020). High temperature stress response is not sexually dimorphic at the whole-body level and is dependent on androgens to induce sex reversal. Gen. Comp. Endocrinol., 299: Art. 113605.
DOI: 10.1016/j.ygcen.2020.113605

Colson, Tash-Lynn L.; de Solla, Shane R.; Balakrishnan, Vimal K.; Toito, John & Langlois, Valérie S. (2020). N-phenyl-1-naphthylamine (PNA) accumulates in snapping turtle (Chelydra serpentina) liver activating the detoxification pathway. Bull. Env. Contam. Toxicol., 105: 813-818.
DOI: 10.1007/s00128-020-03043-0

Dominique, Mélanie; Letcher, Robert J.; Rutter, Allison & Langlois, Valérie S. (2020). Comparative review of the distribution and burden of contaminants in the body of polar bears. Environ. Sci. Pollut. Res., 27: 32456–32466.
DOI: 10.1007/s11356-020-09193-2

Hayhurst, Lauren D.; Martin, Jonathan D.; Wallace, Sarah J.; Langlois, Valérie S.; Xenopoulos, Marguerite A.; Metcalfe, Chris D. & Rennie, Michael D. (2020). Multi-level responses of yellow perch (Perca flavescens) to a whole-lake nanosilver addition study. Arch. Environ. Con. Toxicol., 79 (3): 283-297.
DOI: 10.1007/s00244-020-00764-5

Hodson, Peter V.; Wallace, Sarah J.; de Solla, Shane R.; Head, Jessica A.; Hepditch, Scott; Parrott, Joanne L.; Thomas, Philippe J.; Berthiaume, Alicia & Langlois, Valérie S. (2020). Polycyclic aromatic compounds (PACs) in the Canadian environment: The challenges of ecological risk assessments. Environ. Pollut., 266 part 2: Art. 115165.
DOI: 10.1016/j.envpol.2020.115165

Langlois, Valérie S.; Allison, Michael J.; Bergman, Lauren C.; To, Tuan Anh & Helbing, Caren C. (2020). The need for robust qPCR-based eDNA detection assays in environmental monitoring and species inventories. Environ. DNA, ONLINE.
DOI: 10.1002/edn3.164

Madison, Barry N.; Wallace, Sarah J.; Zhang, Jing; Hodson, Peter V. & Langlois, Valérie S. (2020). Transcriptional responses in newly-hatched Japanese medaka (Oryzias latipes) associated with developmental malformations following diluted bitumen exposure. Comp. Biochem. Physiol. (D) Genom. Proteom., 35: Art. 100685.
DOI: 10.1016/j.cbd.2020.100685

Robitaille, Julie & Langlois, Valérie S. (2020). Consequences of steroid-5″-reductase deficiency and inhibition in vertebrates. Gen. Comp. Endocrinol., 290: Art. 13400.
DOI: 10.1016/j.ygcen.2020.113400

Timlick, Lauren; Peters, Lisa E.; Wallace, Sarah J.; Dettman, Heather; Brown, Stephen R.; Mason, Johanna; Langlois, Valérie S. & Palace, Vince P. (2020). Effects of environmentally relevant residual levels of diluted bitumen on wild fathead minnows (Pimephales promelas). Bull. Env. Contam. Toxicol., 105: 699-704.
DOI: 10.1007/s00128-020-03008-3

Trudeau, Vance L.; Thompson, Paisley E; Zhang, Wo Su; Reynaud, Stephane; Navarro-Martin, Laia & Langlois, Valérie S. (2020). Agrochemicals disrupt multiple endocrine axes in amphibians. Mol. Cell. Endocrino., 513: Art. 110861.
DOI: 10.1016/j.mce.2020.110861

Wallace, Sarah J.; Leclerc, A. J. A.; Prosser, R. S.; de Solla, Shane R.; Balakrishnan, V. K. & Langlois, Valérie S. (2020). Sub-lethal effects of calcium dinonylnaphthalenesulfonate on Western clawed frog embryos. Comp. Biochem. Physiol. (D) Genom. Proteom., 34: Art. 100658.
DOI: 10.1016/j.cbd.2020.100658

Wallace, Sarah J.; de Solla, Shane R.; Head, Jessica A.; Hodson, Peter V.; Parrott, Joanne L.; Thomas, Philippe J.; Berthiaume, Alicia & Langlois, Valérie S. (2020). Polycyclic aromatic compounds (PACs) in the Canadian environment: Exposure and effects on wildlife. Environ. Pollut., 265 part B: Art. 114863.
DOI: 10.1016/j.envpol.2020.114863

Beirao, Jose; Baillon, Lucie; Litt, Margaret A.; Langlois, Valérie S. & Purchase, Craig F. (2019). Impact of crude oil and the dispersant CorexitTM EC9500A on capelin (Mallotus villosus) embryo developmentMar. Environ. Res., 147: 90-100.
DOI: 10.1016/j.marenvres.2019.04.004

Castaneda Cortes, Diana C.; Arias Padilla, Luisa F.; Langlois, Valérie S.; Somoza, Gustavo M. & Fernandino, Juan I. (2019). The central nervous system acts as a transducer of stress-induced masculinization through corticotropin-releasing hormone BDevelopment, 146 (8): Art. dev172866.
DOI: 10.1242/dev.172866

Gutierrez-Villagomez, Juan Manuel; Martyniuk, Christopher J.; Xing, Lei; Langlois, Valérie S.; Pauli, Bruce D.; Blais, Jules M. & Trudeau, Vance L. (2019). Transcriptome analysis reveals that naphthenic acids perturb gene networks related to metabolic processes, membrane integrity, and gut function in Silurana (Xenopus) tropicalis embryos. Front. Mar. Sci., 6: Art. 533.
DOI: 10.3389/fmars.2019.00533

Lara-Jacobo, Linda Ramona; Williard, Brianna; Wallace, Sarah J. & Langlois, Valérie S. (2019). Cytochrome P450 1A transcript is a suitable biomarker of both exposure and response to diluted bitumen in developing frog embryosEnviron. Pollut., 246: 501-508.
DOI: 10.1016/j.envpol.2018.12.039

McDonnell, Denby; Barry, Madison N.; Baillon, Lucie; Wallace, Sarah J.; Brown, Stephen R.; Hodson, Peter V. & Langlois, Valérie S. (2019). Comparative toxicity of two diluted bitumens to developing yellow perch (Perca flavescens)Sci. Total Environ., 655: 977-985.
DOI: 10.1016/j.scitotenv.2018.11.199

Zhang, Jing; Knight, Rosalinda; Wang, Yushan; Sawyer, Thomas W.; Martyniuk, Christopher J. & Langlois, Valérie S. (2019). Hair follicle miRNAs: a novel biomarker for primary blast induced-mild traumatic brain injuryBiomarkers, 24 (2): 166-179.
DOI: 10.1080/1354750X.2018.1531929

Alsaadi, Ftoon; Hodson, Peter V. & Langlois, Valérie S. (2018). An embryonic field of study: The aquatic fate and toxicity of diluted bitumenBull. Env. Contam. Toxicol., 100 (1): 8-13.
DOI: 10.1007/s00128-017-2239-7

Alsaadi, Ftoon; Madison, Barry N.; Brown, R. S.; Hodson, P. V. & Langlois, Valérie S. (2018). Morphological and molecular effects of two diluted bitumens on developing fathead minnow (Pimephales promelas)Aquat. Toxicol., 204: 107-116.
DOI: 10.1016/j.aquatox.2018.09.003

Bissegger, Sonja; Castro, Marco A. Pineda; Yargeau, Viviane & Langlois, Valérie S. (2018). Phthalates modulate steroid 5-reductase transcripts in the Western clawed frog embryoComp. Biochem. Physiol. (C), 213: 39-46.
DOI: 10.1016/j.cbpc.2018.07.005

Campbell, Diana E. K. & Langlois, Valérie S. (2018). Expression of sf1 and dax-1 are regulated by thyroid hormones and androgens during Silurana tropicalis early developmentGen. Comp. Endocr., 259: 34-44.
DOI: 10.1016/j.ygcen.2017.10.017

Campbell, Diana E. K. & Langlois, Valérie S. (2018). Thyroid hormones and androgens differentially regulate gene expression in testes and ovaries of sexually mature Silurana tropicalisGen. Comp. Endocr., 267: 172-182.
DOI: 10.1016/j.ygcen.2018.07.001

Campbell, Diana E. K.; Montgomerie, Robert D. & Langlois, Valérie S. (2018). Lifecycle exposure to perchlorate differentially alters morphology, biochemistry, and transcription as well as sperm motility in Silurana tropicalis frogsEnviron. Pollut., 237: 196-204.
DOI: 10.1016/j.envpol.2018.02.038

Thompson, Paisley & Langlois, Valérie S. (2018). Developmental profiles of progesterone receptor transcripts and molecular responses to gestagen exposure during Silurana tropicalis early developmentGen. Comp. Endocr., 265: 4-14.
DOI: 10.1016/j.ygcen.2018.05.017

Wallace, S. J.; de Solla, S. R.; Thomas, P. J.; Harner, T.; Eng, A. & Langlois, Valérie S. (2018). Airborne polycyclic aromatic compounds contribute to the induction of the tumour-suppressing P53 pathway in wild double-crested cormorantsEcotox. Environ. Safe., 150: 176-189.
DOI: 10.1016/j.ecoenv.2017.12.028